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S1PR3 (sphingosine-1-phosphate receptor 3)

Identity

Alias_namesEDG3
endothelial differentiation
Alias_symbol (synonym)EDG-3
Other aliasLPB3
S1P3
HGNC (Hugo) S1PR3
LocusID (NCBI) 1903
Atlas_Id 49930
Location 9q22.1  [Link to chromosome band 9q22]
Location_base_pair Starts at 88991409 and ends at 89005154 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)S1PR3   3167
Cards
Entrez_Gene (NCBI)S1PR3  1903  sphingosine-1-phosphate receptor 3
AliasesEDG-3; EDG3; LPB3; S1P3
GeneCards (Weizmann)S1PR3
Ensembl hg19 (Hinxton)ENSG00000213694 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213694 [Gene_View]  chr9:88991409-89005154 [Contig_View]  S1PR3 [Vega]
ICGC DataPortalENSG00000213694
TCGA cBioPortalS1PR3
AceView (NCBI)S1PR3
Genatlas (Paris)S1PR3
WikiGenes1903
SOURCE (Princeton)S1PR3
Genetics Home Reference (NIH)S1PR3
Genomic and cartography
GoldenPath hg38 (UCSC)S1PR3  -     chr9:88991409-89005154 +  9q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)S1PR3  -     9q22.1   [Description]    (hg19-Feb_2009)
EnsemblS1PR3 - 9q22.1 [CytoView hg19]  S1PR3 - 9q22.1 [CytoView hg38]
Mapping of homologs : NCBIS1PR3 [Mapview hg19]  S1PR3 [Mapview hg38]
OMIM601965   
Gene and transcription
Genbank (Entrez)AF022139 AK312798 AL832194 BC060827 BC069579
RefSeq transcript (Entrez)NM_005226
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)S1PR3
Cluster EST : UnigeneHs.585118 [ NCBI ]
CGAP (NCI)Hs.585118
Alternative Splicing GalleryENSG00000213694
Gene ExpressionS1PR3 [ NCBI-GEO ]   S1PR3 [ EBI - ARRAY_EXPRESS ]   S1PR3 [ SEEK ]   S1PR3 [ MEM ]
Gene Expression Viewer (FireBrowse)S1PR3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1903
GTEX Portal (Tissue expression)S1PR3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99500   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99500  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99500
Splice isoforms : SwissVarQ99500
PhosPhoSitePlusQ99500
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)EDG3_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    S1P_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)S1PR3
DMDM Disease mutations1903
Blocks (Seattle)S1PR3
SuperfamilyQ99500
Human Protein AtlasENSG00000213694
Peptide AtlasQ99500
HPRD03572
IPIIPI00015983   
Protein Interaction databases
DIP (DOE-UCLA)Q99500
IntAct (EBI)Q99500
FunCoupENSG00000213694
BioGRIDS1PR3
STRING (EMBL)S1PR3
ZODIACS1PR3
Ontologies - Pathways
QuickGOQ99500
Ontology : AmiGOcytokine production  sphingosine-1-phosphate signaling pathway  G-protein coupled receptor activity  integrin binding  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  inflammatory response  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  Notch signaling pathway  positive regulation of cell proliferation  lipid binding  anatomical structure morphogenesis  regulation of interleukin-1 beta production  sphingosine-1-phosphate receptor activity  negative regulation of establishment of endothelial barrier  
Ontology : EGO-EBIcytokine production  sphingosine-1-phosphate signaling pathway  G-protein coupled receptor activity  integrin binding  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  inflammatory response  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  Notch signaling pathway  positive regulation of cell proliferation  lipid binding  anatomical structure morphogenesis  regulation of interleukin-1 beta production  sphingosine-1-phosphate receptor activity  negative regulation of establishment of endothelial barrier  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkS1PR3
Atlas of Cancer Signalling NetworkS1PR3
Wikipedia pathwaysS1PR3
Orthology - Evolution
OrthoDB1903
GeneTree (enSembl)ENSG00000213694
Phylogenetic Trees/Animal Genes : TreeFamS1PR3
HOVERGENQ99500
HOGENOMQ99500
Homologs : HomoloGeneS1PR3
Homology/Alignments : Family Browser (UCSC)S1PR3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerS1PR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)S1PR3
dbVarS1PR3
ClinVarS1PR3
1000_GenomesS1PR3 
Exome Variant ServerS1PR3
ExAC (Exome Aggregation Consortium)S1PR3 (select the gene name)
Genetic variants : HAPMAP1903
Genomic Variants (DGV)S1PR3 [DGVbeta]
DECIPHERS1PR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisS1PR3 
Mutations
ICGC Data PortalS1PR3 
TCGA Data PortalS1PR3 
Broad Tumor PortalS1PR3
OASIS PortalS1PR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICS1PR3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDS1PR3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch S1PR3
DgiDB (Drug Gene Interaction Database)S1PR3
DoCM (Curated mutations)S1PR3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)S1PR3 (select a term)
intoGenS1PR3
Cancer3DS1PR3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601965   
Orphanet
MedgenS1PR3
Genetic Testing Registry S1PR3
NextProtQ99500 [Medical]
TSGene1903
GENETestsS1PR3
Target ValidationS1PR3
Huge Navigator S1PR3 [HugePedia]
snp3D : Map Gene to Disease1903
BioCentury BCIQS1PR3
ClinGenS1PR3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1903
Chemical/Pharm GKB GenePA162402362
Clinical trialS1PR3
Miscellaneous
canSAR (ICR)S1PR3 (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineS1PR3
EVEXS1PR3
GoPubMedS1PR3
iHOPS1PR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:29:50 CEST 2017

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