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S1PR4 (sphingosine-1-phosphate receptor 4)

Identity

Alias_namesEDG6
endothelial differentiation, G-protein-coupled receptor 6
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6
Other aliasLPC1
S1P4
SLP4
HGNC (Hugo) S1PR4
LocusID (NCBI) 8698
Atlas_Id 43047
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 3178736 and ends at 3180330 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)S1PR4   3170
Cards
Entrez_Gene (NCBI)S1PR4  8698  sphingosine-1-phosphate receptor 4
AliasesEDG6; LPC1; S1P4; SLP4
GeneCards (Weizmann)S1PR4
Ensembl hg19 (Hinxton)ENSG00000125910 [Gene_View]  chr19:3178736-3180330 [Contig_View]  S1PR4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000125910 [Gene_View]  chr19:3178736-3180330 [Contig_View]  S1PR4 [Vega]
ICGC DataPortalENSG00000125910
TCGA cBioPortalS1PR4
AceView (NCBI)S1PR4
Genatlas (Paris)S1PR4
WikiGenes8698
SOURCE (Princeton)S1PR4
Genetics Home Reference (NIH)S1PR4
Genomic and cartography
GoldenPath hg19 (UCSC)S1PR4  -     chr19:3178736-3180330 +  19p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)S1PR4  -     19p13.3   [Description]    (hg38-Dec_2013)
EnsemblS1PR4 - 19p13.3 [CytoView hg19]  S1PR4 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIS1PR4 [Mapview hg19]  S1PR4 [Mapview hg38]
OMIM603751   
Gene and transcription
Genbank (Entrez)AJ000479 BC014970 FJ200495
RefSeq transcript (Entrez)NM_003775
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929412
Consensus coding sequences : CCDS (NCBI)S1PR4
Cluster EST : UnigeneHs.662006 [ NCBI ]
CGAP (NCI)Hs.662006
Alternative Splicing GalleryENSG00000125910
Gene ExpressionS1PR4 [ NCBI-GEO ]   S1PR4 [ EBI - ARRAY_EXPRESS ]   S1PR4 [ SEEK ]   S1PR4 [ MEM ]
Gene Expression Viewer (FireBrowse)S1PR4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8698
GTEX Portal (Tissue expression)S1PR4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95977   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95977  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95977
Splice isoforms : SwissVarO95977
PhosPhoSitePlusO95977
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)EDG6_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    S1P_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)S1PR4
DMDM Disease mutations8698
Blocks (Seattle)S1PR4
PDB (SRS)2DCO   
PDB (PDBSum)2DCO   
PDB (IMB)2DCO   
PDB (RSDB)2DCO   
Structural Biology KnowledgeBase2DCO   
SCOP (Structural Classification of Proteins)2DCO   
CATH (Classification of proteins structures)2DCO   
SuperfamilyO95977
Human Protein AtlasENSG00000125910
Peptide AtlasO95977
HPRD04779
IPIIPI00021534   IPI00980292   
Protein Interaction databases
DIP (DOE-UCLA)O95977
IntAct (EBI)O95977
FunCoupENSG00000125910
BioGRIDS1PR4
STRING (EMBL)S1PR4
ZODIACS1PR4
Ontologies - Pathways
QuickGOO95977
Ontology : AmiGOsphingosine-1-phosphate signaling pathway  G-protein coupled receptor activity  plasma membrane  integral component of plasma membrane  immune response  G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of phospholipase C activity  positive regulation of cytosolic calcium ion concentration  lipid binding  sphingosine-1-phosphate receptor activity  
Ontology : EGO-EBIsphingosine-1-phosphate signaling pathway  G-protein coupled receptor activity  plasma membrane  integral component of plasma membrane  immune response  G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of phospholipase C activity  positive regulation of cytosolic calcium ion concentration  lipid binding  sphingosine-1-phosphate receptor activity  
Pathways : KEGGFoxO signaling pathway    Neuroactive ligand-receptor interaction   
NDEx NetworkS1PR4
Atlas of Cancer Signalling NetworkS1PR4
Wikipedia pathwaysS1PR4
Orthology - Evolution
OrthoDB8698
GeneTree (enSembl)ENSG00000125910
Phylogenetic Trees/Animal Genes : TreeFamS1PR4
HOVERGENO95977
HOGENOMO95977
Homologs : HomoloGeneS1PR4
Homology/Alignments : Family Browser (UCSC)S1PR4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerS1PR4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)S1PR4
dbVarS1PR4
ClinVarS1PR4
1000_GenomesS1PR4 
Exome Variant ServerS1PR4
ExAC (Exome Aggregation Consortium)S1PR4 (select the gene name)
Genetic variants : HAPMAP8698
Genomic Variants (DGV)S1PR4 [DGVbeta]
DECIPHER (Syndromes)19:3178736-3180330  ENSG00000125910
CONAN: Copy Number AnalysisS1PR4 
Mutations
ICGC Data PortalS1PR4 
TCGA Data PortalS1PR4 
Broad Tumor PortalS1PR4
OASIS PortalS1PR4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICS1PR4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDS1PR4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch S1PR4
DgiDB (Drug Gene Interaction Database)S1PR4
DoCM (Curated mutations)S1PR4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)S1PR4 (select a term)
intoGenS1PR4
Cancer3DS1PR4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603751   
Orphanet
MedgenS1PR4
Genetic Testing Registry S1PR4
NextProtO95977 [Medical]
TSGene8698
GENETestsS1PR4
Huge Navigator S1PR4 [HugePedia]
snp3D : Map Gene to Disease8698
BioCentury BCIQS1PR4
ClinGenS1PR4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8698
Chemical/Pharm GKB GenePA162402371
Clinical trialS1PR4
Miscellaneous
canSAR (ICR)S1PR4 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineS1PR4
EVEXS1PR4
GoPubMedS1PR4
iHOPS1PR4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:26:03 CET 2017

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