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S1PR5 (sphingosine-1-phosphate receptor 5)

Identity

Alias_namesEDG8
endothelial differentiation
Alias_symbol (synonym)Edg-8
Other aliasS1P5
SPPR-1
SPPR-2
HGNC (Hugo) S1PR5
LocusID (NCBI) 53637
Atlas_Id 46503
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 10623418 and ends at 10628668 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FAM219A (9p13.3) / S1PR5 (19p13.2)PDE4A (19p13.2) / S1PR5 (19p13.2)S1PR5 (19p13.2) / S1PR5 (19p13.2)
WDFY2 (13q14.3) / S1PR5 (19p13.2)PDE4A 19p13.2 / S1PR5 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)S1PR5   14299
Cards
Entrez_Gene (NCBI)S1PR5  53637  sphingosine-1-phosphate receptor 5
AliasesEDG8; Edg-8; S1P5; SPPR-1; 
SPPR-2
GeneCards (Weizmann)S1PR5
Ensembl hg19 (Hinxton)ENSG00000180739 [Gene_View]  chr19:10623418-10628668 [Contig_View]  S1PR5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000180739 [Gene_View]  chr19:10623418-10628668 [Contig_View]  S1PR5 [Vega]
ICGC DataPortalENSG00000180739
TCGA cBioPortalS1PR5
AceView (NCBI)S1PR5
Genatlas (Paris)S1PR5
WikiGenes53637
SOURCE (Princeton)S1PR5
Genetics Home Reference (NIH)S1PR5
Genomic and cartography
GoldenPath hg19 (UCSC)S1PR5  -     chr19:10623418-10628668 -  19p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)S1PR5  -     19p13.2   [Description]    (hg38-Dec_2013)
EnsemblS1PR5 - 19p13.2 [CytoView hg19]  S1PR5 - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBIS1PR5 [Mapview hg19]  S1PR5 [Mapview hg38]
OMIM605146   
Gene and transcription
Genbank (Entrez)AF088014 AF331840 AF331841 AF331842 AK074661
RefSeq transcript (Entrez)NM_001166215 NM_030760
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)S1PR5
Cluster EST : UnigeneHs.501561 [ NCBI ]
CGAP (NCI)Hs.501561
Alternative Splicing GalleryENSG00000180739
Gene ExpressionS1PR5 [ NCBI-GEO ]   S1PR5 [ EBI - ARRAY_EXPRESS ]   S1PR5 [ SEEK ]   S1PR5 [ MEM ]
Gene Expression Viewer (FireBrowse)S1PR5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53637
GTEX Portal (Tissue expression)S1PR5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H228   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H228  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H228
Splice isoforms : SwissVarQ9H228
PhosPhoSitePlusQ9H228
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)EDG8_S1P_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    S1P_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)S1PR5
DMDM Disease mutations53637
Blocks (Seattle)S1PR5
SuperfamilyQ9H228
Human Protein AtlasENSG00000180739
Peptide AtlasQ9H228
HPRD05510
IPIIPI00006152   IPI00432841   IPI00952898   IPI00640105   IPI00179221   
Protein Interaction databases
DIP (DOE-UCLA)Q9H228
IntAct (EBI)Q9H228
FunCoupENSG00000180739
BioGRIDS1PR5
STRING (EMBL)S1PR5
ZODIACS1PR5
Ontologies - Pathways
QuickGOQ9H228
Ontology : AmiGOsphingosine-1-phosphate signaling pathway  plasma membrane  integral component of membrane  sphingosine-1-phosphate receptor activity  regulation of neuron differentiation  
Ontology : EGO-EBIsphingosine-1-phosphate signaling pathway  plasma membrane  integral component of membrane  sphingosine-1-phosphate receptor activity  regulation of neuron differentiation  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkS1PR5
Atlas of Cancer Signalling NetworkS1PR5
Wikipedia pathwaysS1PR5
Orthology - Evolution
OrthoDB53637
GeneTree (enSembl)ENSG00000180739
Phylogenetic Trees/Animal Genes : TreeFamS1PR5
HOVERGENQ9H228
HOGENOMQ9H228
Homologs : HomoloGeneS1PR5
Homology/Alignments : Family Browser (UCSC)S1PR5
Gene fusions - Rearrangements
Fusion : MitelmanFAM219A/S1PR5 [9p13.3/19p13.2]  [t(9;19)(p13;p13)]  
Fusion : MitelmanPDE4A/S1PR5 [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanWDFY2/S1PR5 [13q14.3/19p13.2]  [t(13;19)(q14;p13)]  
Fusion: TCGAPDE4A 19p13.2 S1PR5 19p13.2 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerS1PR5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)S1PR5
dbVarS1PR5
ClinVarS1PR5
1000_GenomesS1PR5 
Exome Variant ServerS1PR5
ExAC (Exome Aggregation Consortium)S1PR5 (select the gene name)
Genetic variants : HAPMAP53637
Genomic Variants (DGV)S1PR5 [DGVbeta]
DECIPHER (Syndromes)19:10623418-10628668  ENSG00000180739
CONAN: Copy Number AnalysisS1PR5 
Mutations
ICGC Data PortalS1PR5 
TCGA Data PortalS1PR5 
Broad Tumor PortalS1PR5
OASIS PortalS1PR5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICS1PR5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDS1PR5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch S1PR5
DgiDB (Drug Gene Interaction Database)S1PR5
DoCM (Curated mutations)S1PR5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)S1PR5 (select a term)
intoGenS1PR5
Cancer3DS1PR5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605146   
Orphanet
MedgenS1PR5
Genetic Testing Registry S1PR5
NextProtQ9H228 [Medical]
TSGene53637
GENETestsS1PR5
Huge Navigator S1PR5 [HugePedia]
snp3D : Map Gene to Disease53637
BioCentury BCIQS1PR5
ClinGenS1PR5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD53637
Chemical/Pharm GKB GenePA162402378
Clinical trialS1PR5
Miscellaneous
canSAR (ICR)S1PR5 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineS1PR5
EVEXS1PR5
GoPubMedS1PR5
iHOPS1PR5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:26:03 CET 2017

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