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SAFB (scaffold attachment factor B)

Identity

Alias_symbol (synonym)HET
SAFB1
Other aliasHAP
SAB-B1
SAF-B
SAF-B1
HGNC (Hugo) SAFB
LocusID (NCBI) 6294
Atlas_Id 42197
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 5623035 and ends at 5668478 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HSD11B1L (19p13.3) / SAFB (19p13.3)NUDT7 (16q23.1) / SAFB (19p13.3)SAFB (19p13.3) / C2orf61 (2p21)
SAFB (19p13.3) / KIF13B (8p12)SAFB (19p13.3) / SAFB (19p13.3)ZNF83 (19q13.41) / SAFB (19p13.3)
cytochrome_b () / SAFB (19p13.3)HSD11B1L 19p13.3 / SAFB 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SAFB   10520
Cards
Entrez_Gene (NCBI)SAFB  6294  scaffold attachment factor B
AliasesHAP; HET; SAB-B1; SAF-B; 
SAF-B1; SAFB1
GeneCards (Weizmann)SAFB
Ensembl hg19 (Hinxton)ENSG00000160633 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160633 [Gene_View]  chr19:5623035-5668478 [Contig_View]  SAFB [Vega]
ICGC DataPortalENSG00000160633
TCGA cBioPortalSAFB
AceView (NCBI)SAFB
Genatlas (Paris)SAFB
WikiGenes6294
SOURCE (Princeton)SAFB
Genetics Home Reference (NIH)SAFB
Genomic and cartography
GoldenPath hg38 (UCSC)SAFB  -     chr19:5623035-5668478 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SAFB  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblSAFB - 19p13.3 [CytoView hg19]  SAFB - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBISAFB [Mapview hg19]  SAFB [Mapview hg38]
OMIM602895   
Gene and transcription
Genbank (Entrez)AB208780 AK095736 AK290444 AK293152 AK294671
RefSeq transcript (Entrez)NM_001201338 NM_001201339 NM_001201340 NM_001320571 NM_001320572 NM_002967
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SAFB
Cluster EST : UnigeneHs.728802 [ NCBI ]
CGAP (NCI)Hs.728802
Alternative Splicing GalleryENSG00000160633
Gene ExpressionSAFB [ NCBI-GEO ]   SAFB [ EBI - ARRAY_EXPRESS ]   SAFB [ SEEK ]   SAFB [ MEM ]
Gene Expression Viewer (FireBrowse)SAFB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6294
GTEX Portal (Tissue expression)SAFB
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15424   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15424  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15424
Splice isoforms : SwissVarQ15424
PhosPhoSitePlusQ15424
Domaine pattern : Prosite (Expaxy)RRM (PS50102)    SAP (PS50800)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    RRM_dom    SAP_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)    SAP (PF02037)   
Domain families : Pfam (NCBI)pfam00076    pfam02037   
Domain families : Smart (EMBL)RRM (SM00360)  SAP (SM00513)  
Conserved Domain (NCBI)SAFB
DMDM Disease mutations6294
Blocks (Seattle)SAFB
SuperfamilyQ15424
Human Protein AtlasENSG00000160633
Peptide AtlasQ15424
HPRD04205
IPIIPI00300631   IPI01018318   IPI01013398   IPI00983392   IPI00646058   IPI00941773   
Protein Interaction databases
DIP (DOE-UCLA)Q15424
IntAct (EBI)Q15424
FunCoupENSG00000160633
BioGRIDSAFB
STRING (EMBL)SAFB
ZODIACSAFB
Ontologies - Pathways
QuickGOQ15424
Ontology : AmiGOcore promoter binding  chromatin binding  double-stranded DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  chromatin organization  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  intracellular estrogen receptor signaling pathway  growth  hormone metabolic process  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  regulation of mRNA processing  
Ontology : EGO-EBIcore promoter binding  chromatin binding  double-stranded DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  chromatin organization  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  intracellular estrogen receptor signaling pathway  growth  hormone metabolic process  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  regulation of mRNA processing  
NDEx NetworkSAFB
Atlas of Cancer Signalling NetworkSAFB
Wikipedia pathwaysSAFB
Orthology - Evolution
OrthoDB6294
GeneTree (enSembl)ENSG00000160633
Phylogenetic Trees/Animal Genes : TreeFamSAFB
HOVERGENQ15424
HOGENOMQ15424
Homologs : HomoloGeneSAFB
Homology/Alignments : Family Browser (UCSC)SAFB
Gene fusions - Rearrangements
Fusion : MitelmanHSD11B1L/SAFB [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion: TCGAHSD11B1L 19p13.3 SAFB 19p13.3 HNSC
Fusion Cancer (Beijing)cytochrome_b [SAFB]  -  19p13.3 [FUSC000432]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSAFB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SAFB
dbVarSAFB
ClinVarSAFB
1000_GenomesSAFB 
Exome Variant ServerSAFB
ExAC (Exome Aggregation Consortium)SAFB (select the gene name)
Genetic variants : HAPMAP6294
Genomic Variants (DGV)SAFB [DGVbeta]
DECIPHERSAFB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSAFB 
Mutations
ICGC Data PortalSAFB 
TCGA Data PortalSAFB 
Broad Tumor PortalSAFB
OASIS PortalSAFB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSAFB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSAFB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SAFB
DgiDB (Drug Gene Interaction Database)SAFB
DoCM (Curated mutations)SAFB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SAFB (select a term)
intoGenSAFB
Cancer3DSAFB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602895   
Orphanet
MedgenSAFB
Genetic Testing Registry SAFB
NextProtQ15424 [Medical]
TSGene6294
GENETestsSAFB
Target ValidationSAFB
Huge Navigator SAFB [HugePedia]
snp3D : Map Gene to Disease6294
BioCentury BCIQSAFB
ClinGenSAFB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6294
Chemical/Pharm GKB GenePA34928
Clinical trialSAFB
Miscellaneous
canSAR (ICR)SAFB (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSAFB
EVEXSAFB
GoPubMedSAFB
iHOPSAFB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:54:18 CEST 2017

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