SALL4 (spalt like transcription factor 4)

2007-02-01  

Identity

HGNC
LOCATION
20q13.2
LOCUSID
ALIAS
DRRS,HSAL4,ZNF797

Other Information

Locus ID:

NCBI: 57167
MIM: 607343
HGNC: 15924
Ensembl: ENSG00000101115

Variants:

dbSNP: 57167
ClinVar: 57167
TCGA: ENSG00000101115
COSMIC: SALL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101115ENST00000217086Q9UJQ4
ENSG00000101115ENST00000371539Q6Y8G5
ENSG00000101115ENST00000395997Q9UJQ4

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of pluripotent stem cellsREACTOMER-HSA-452723
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferationREACTOMER-HSA-2892247

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
167632122006SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice.89
123952972002Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family.84
123938092002Okihiro syndrome is caused by SALL4 mutations.76
205058212010A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells.65
237582322013Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.65
175578352007Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells.62
194405522009Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex.59
259195702015MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1.59
184875082008SALL4 is a key regulator of survival and apoptosis in human leukemic cells.54

Citation

Dessen P

SALL4 (spalt like transcription factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45524/sall4