SAMSN1 (SAM domain, SH3 domain and nuclear localization signals 1)

2003-02-01  

Identity

HGNC
LOCATION
21q11.2
LOCUSID
ALIAS
HACS1,NASH1,SASH2,SH3D6B,SLy2

Other Information

Locus ID:

NCBI: 64092
MIM: 607978
HGNC: 10528
Ensembl: ENSG00000155307

Variants:

dbSNP: 64092
ClinVar: 64092
TCGA: ENSG00000155307
COSMIC: SAMSN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155307ENST00000285670Q9NSI8
ENSG00000155307ENST00000400564Q9NSI8
ENSG00000155307ENST00000400566Q9NSI8
ENSG00000155307ENST00000619120S6FRS6
ENSG00000155307ENST00000647101A0A2R8Y4K8

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
185239972008Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer.34
153817292004The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades.18
251179792014SAMSN1 is a tumor suppressor gene in multiple myeloma.15
212968792011Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.9
242784652013SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.8
204783932010SLy2 targets the nuclear SAP30/HDAC1 complex.5
258052362015Suppression of SAMSN1 Expression is Associated with the Malignant Phenotype of Hepatocellular Carcinoma.5

Citation

Dessen P

SAMSN1 (SAM domain, SH3 domain and nuclear localization signals 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42200/samsn1