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SARM1 (sterile alpha and TIR motif containing 1)

Identity

Alias (NCBI)MyD88-5
SAMD2
SARM
HGNC (Hugo) SARM1
HGNC Alias symbSARM
SAMD2
KIAA0524
LocusID (NCBI) 23098
Atlas_Id 72981
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 28371662 and ends at 28401038 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
REXO2 (11q23.2) / SARM1 (17q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SARM1   17074
Cards
Entrez_Gene (NCBI)SARM1  23098  sterile alpha and TIR motif containing 1
AliasesMyD88-5; SAMD2; SARM
GeneCards (Weizmann)SARM1
Ensembl hg19 (Hinxton)ENSG00000004139 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000004139 [Gene_View]  ENSG00000004139 [Sequence]  chr17:28371662-28401038 [Contig_View]  SARM1 [Vega]
ICGC DataPortalENSG00000004139
TCGA cBioPortalSARM1
AceView (NCBI)SARM1
Genatlas (Paris)SARM1
WikiGenes23098
SOURCE (Princeton)SARM1
Genetics Home Reference (NIH)SARM1
Genomic and cartography
GoldenPath hg38 (UCSC)SARM1  -     chr17:28371662-28401038 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SARM1  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathSARM1 - 17q11.2 [CytoView hg19]  SARM1 - 17q11.2 [CytoView hg38]
ImmunoBaseENSG00000004139
genome Data Viewer NCBISARM1 [Mapview hg19]  
OMIM607732   
Gene and transcription
Genbank (Entrez)AB011096 AJ290445 AK026397 AK093615 AK302038
RefSeq transcript (Entrez)NM_015077
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SARM1
Alternative Splicing GalleryENSG00000004139
Gene ExpressionSARM1 [ NCBI-GEO ]   SARM1 [ EBI - ARRAY_EXPRESS ]   SARM1 [ SEEK ]   SARM1 [ MEM ]
Gene Expression Viewer (FireBrowse)SARM1 [ Firebrowse - Broad ]
GenevisibleExpression of SARM1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23098
GTEX Portal (Tissue expression)SARM1
Human Protein AtlasENSG00000004139-SARM1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6SZW1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6SZW1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6SZW1
Splice isoforms : SwissVarQ6SZW1
PhosPhoSitePlusQ6SZW1
Domaine pattern : Prosite (Expaxy)SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    SAM    SAM/pointed_sf    SARM1    TIR_dom    Toll_tir_struct_dom_sf   
Domain families : Pfam (Sanger)SAM_2 (PF07647)    TIR_2 (PF13676)   
Domain families : Pfam (NCBI)pfam07647    pfam13676   
Domain families : Smart (EMBL)SAM (SM00454)  TIR (SM00255)  
Conserved Domain (NCBI)SARM1
DMDM Disease mutations23098
Blocks (Seattle)SARM1
PDB (RSDB)6O0Q    6O0R    6O0S    6O0T    6O0U    6O0V    6O1B    6QWV   
PDB Europe6O0Q    6O0R    6O0S    6O0T    6O0U    6O0V    6O1B    6QWV   
PDB (PDBSum)6O0Q    6O0R    6O0S    6O0T    6O0U    6O0V    6O1B    6QWV   
PDB (IMB)6O0Q    6O0R    6O0S    6O0T    6O0U    6O0V    6O1B    6QWV   
Structural Biology KnowledgeBase6O0Q    6O0R    6O0S    6O0T    6O0U    6O0V    6O1B    6QWV   
SCOP (Structural Classification of Proteins)6O0Q    6O0R    6O0S    6O0T    6O0U    6O0V    6O1B    6QWV   
CATH (Classification of proteins structures)6O0Q    6O0R    6O0S    6O0T    6O0U    6O0V    6O1B    6QWV   
SuperfamilyQ6SZW1
Human Protein Atlas [tissue]ENSG00000004139-SARM1 [tissue]
Peptide AtlasQ6SZW1
IPIIPI00908858   
Protein Interaction databases
DIP (DOE-UCLA)Q6SZW1
IntAct (EBI)Q6SZW1
FunCoupENSG00000004139
BioGRIDSARM1
STRING (EMBL)SARM1
ZODIACSARM1
Ontologies - Pathways
QuickGOQ6SZW1
Ontology : AmiGOprotein binding  cytoplasm  mitochondrion  cytosol  microtubule  signal transduction  response to glucose  positive regulation of signal transduction  cell junction  axon  dendrite  dendrite  extrinsic component of mitochondrial outer membrane  negative regulation of MyD88-independent toll-like receptor signaling pathway  signaling adaptor activity  regulation of apoptotic process  innate immune response  synapse  response to axon injury  regulation of dendrite morphogenesis  regulation of neuron death  regulation of neuron death  
Ontology : EGO-EBIprotein binding  cytoplasm  mitochondrion  cytosol  microtubule  signal transduction  response to glucose  positive regulation of signal transduction  cell junction  axon  dendrite  dendrite  extrinsic component of mitochondrial outer membrane  negative regulation of MyD88-independent toll-like receptor signaling pathway  signaling adaptor activity  regulation of apoptotic process  innate immune response  synapse  response to axon injury  regulation of dendrite morphogenesis  regulation of neuron death  regulation of neuron death  
NDEx NetworkSARM1
Atlas of Cancer Signalling NetworkSARM1
Wikipedia pathwaysSARM1
Orthology - Evolution
OrthoDB23098
GeneTree (enSembl)ENSG00000004139
Phylogenetic Trees/Animal Genes : TreeFamSARM1
HOGENOMQ6SZW1
Homologs : HomoloGeneSARM1
Homology/Alignments : Family Browser (UCSC)SARM1
Gene fusions - Rearrangements
Fusion : QuiverSARM1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSARM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SARM1
dbVarSARM1
ClinVarSARM1
1000_GenomesSARM1 
Exome Variant ServerSARM1
GNOMAD BrowserENSG00000004139
Varsome BrowserSARM1
Genetic variants : HAPMAP23098
Genomic Variants (DGV)SARM1 [DGVbeta]
DECIPHERSARM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSARM1 
Mutations
ICGC Data PortalSARM1 
TCGA Data PortalSARM1 
Broad Tumor PortalSARM1
OASIS PortalSARM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSARM1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSARM1
Mutations and Diseases : HGMDSARM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SARM1
DgiDB (Drug Gene Interaction Database)SARM1
DoCM (Curated mutations)SARM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SARM1 (select a term)
intoGenSARM1
Cancer3DSARM1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607732   
Orphanet
DisGeNETSARM1
MedgenSARM1
Genetic Testing Registry SARM1
NextProtQ6SZW1 [Medical]
TSGene23098
GENETestsSARM1
Target ValidationSARM1
Huge Navigator SARM1 [HugePedia]
snp3D : Map Gene to Disease23098
BioCentury BCIQSARM1
ClinGenSARM1
Clinical trials, drugs, therapy
Protein Interactions : CTD23098
Pharm GKB GenePA134971180
Clinical trialSARM1
Miscellaneous
canSAR (ICR)SARM1 (select the gene name)
HarmonizomeSARM1
DataMed IndexSARM1
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSARM1
EVEXSARM1
GoPubMedSARM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Aug 22 19:33:47 CEST 2020

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