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SART1 (spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP)

Identity

Alias (NCBI)Ara1
HAF
HOMS1
SART1259
SNRNP110
Snu66
HGNC (Hugo) SART1
HGNC Alias symbAra1
Snu66
SNRNP110
HAF
HGNC Alias namesmall nuclear ribonucleoprotein 110kDa (U4/U6.U5)
 hypoxia associated factor
HGNC Previous namesquamous cell carcinoma antigen recognised by T cells
 squamous cell carcinoma antigen recognized by T cells 1
 squamous cell carcinoma antigen recognized by T-cells 1
 SART1, U4/U6.U5 tri-snRNP-associated protein 1
LocusID (NCBI) 9092
Atlas_Id 42203
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 65961734 and ends at 65980137 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DPF2 (11q13.1) / SART1 (11q13.1)MTL5 (11q13.3) / SART1 (11q13.1)SART1 (11q13.1) / CNTN5 (11q22.1)
SART1 (11q13.1) / DRD4 (11p15.5)SART1 (11q13.1) / ITIH4 (3p21.1)SF3B2 (11q13.1) / SART1 (11q13.1)
MTL5 11q13.3 / SART1 11q13.1SART1 11q13.1 / CNTN5 11q22.1SF3B2 11q13.1 / SART1 11q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SART1   10538
Cards
Entrez_Gene (NCBI)SART1    spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
AliasesAra1; HAF; HOMS1; SART1259; 
SNRNP110; Snu66
GeneCards (Weizmann)SART1
Ensembl hg19 (Hinxton)ENSG00000175467 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175467 [Gene_View]  ENSG00000175467 [Sequence]  chr11:65961734-65980137 [Contig_View]  SART1 [Vega]
ICGC DataPortalENSG00000175467
TCGA cBioPortalSART1
AceView (NCBI)SART1
Genatlas (Paris)SART1
SOURCE (Princeton)SART1
Genetics Home Reference (NIH)SART1
Genomic and cartography
GoldenPath hg38 (UCSC)SART1  -     chr11:65961734-65980137 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SART1  -     11q13.1   [Description]    (hg19-Feb_2009)
GoldenPathSART1 - 11q13.1 [CytoView hg19]  SART1 - 11q13.1 [CytoView hg38]
ImmunoBaseENSG00000175467
Genome Data Viewer NCBISART1 [Mapview hg19]  
OMIM605941   
Gene and transcription
Genbank (Entrez)AB006198 AF353625 AK223016 AK293200 AK297589
RefSeq transcript (Entrez)NM_005146
Consensus coding sequences : CCDS (NCBI)SART1
Gene ExpressionSART1 [ NCBI-GEO ]   SART1 [ EBI - ARRAY_EXPRESS ]   SART1 [ SEEK ]   SART1 [ MEM ]
Gene Expression Viewer (FireBrowse)SART1 [ Firebrowse - Broad ]
GenevisibleExpression of SART1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9092
GTEX Portal (Tissue expression)SART1
Human Protein AtlasENSG00000175467-SART1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43290   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43290  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43290
PhosPhoSitePlusO43290
Domains : Interpro (EBI)SNU66/SART1   
Domain families : Pfam (Sanger)SART-1 (PF03343)   
Domain families : Pfam (NCBI)pfam03343   
Conserved Domain (NCBI)SART1
PDB (RSDB)4PYU    5O9Z    6AHD    6QW6    6QX9   
PDB Europe4PYU    5O9Z    6AHD    6QW6    6QX9   
PDB (PDBSum)4PYU    5O9Z    6AHD    6QW6    6QX9   
PDB (IMB)4PYU    5O9Z    6AHD    6QW6    6QX9   
Structural Biology KnowledgeBase4PYU    5O9Z    6AHD    6QW6    6QX9   
SCOP (Structural Classification of Proteins)4PYU    5O9Z    6AHD    6QW6    6QX9   
CATH (Classification of proteins structures)4PYU    5O9Z    6AHD    6QW6    6QX9   
SuperfamilyO43290
AlphaFold pdb e-kbO43290   
Human Protein Atlas [tissue]ENSG00000175467-SART1 [tissue]
HPRD10440
Protein Interaction databases
DIP (DOE-UCLA)O43290
IntAct (EBI)O43290
BioGRIDSART1
STRING (EMBL)SART1
ZODIACSART1
Ontologies - Pathways
QuickGOO43290
Ontology : AmiGOspliceosomal snRNP assembly  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  maturation of 5S rRNA  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  Cajal body  nuclear speck  mRNA cis splicing, via spliceosome  positive regulation of cytotoxic T cell differentiation  U4/U6 x U5 tri-snRNP complex  U2-type precatalytic spliceosome  catalytic step 2 spliceosome  
Ontology : EGO-EBIspliceosomal snRNP assembly  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  maturation of 5S rRNA  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  Cajal body  nuclear speck  mRNA cis splicing, via spliceosome  positive regulation of cytotoxic T cell differentiation  U4/U6 x U5 tri-snRNP complex  U2-type precatalytic spliceosome  catalytic step 2 spliceosome  
Pathways : KEGGSpliceosome   
NDEx NetworkSART1
Atlas of Cancer Signalling NetworkSART1
Wikipedia pathwaysSART1
Orthology - Evolution
OrthoDB9092
GeneTree (enSembl)ENSG00000175467
Phylogenetic Trees/Animal Genes : TreeFamSART1
Homologs : HomoloGeneSART1
Homology/Alignments : Family Browser (UCSC)SART1
Gene fusions - Rearrangements
Fusion : MitelmanMTL5/SART1 [11q13.3/11q13.1]  
Fusion : MitelmanSART1/CNTN5 [11q13.1/11q22.1]  
Fusion : MitelmanSF3B2/SART1 [11q13.1/11q13.1]  
Fusion : QuiverSART1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSART1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SART1
dbVarSART1
ClinVarSART1
MonarchSART1
1000_GenomesSART1 
Exome Variant ServerSART1
GNOMAD BrowserENSG00000175467
Varsome BrowserSART1
ACMGSART1 variants
VarityO43290
Genomic Variants (DGV)SART1 [DGVbeta]
DECIPHERSART1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSART1 
Mutations
ICGC Data PortalSART1 
TCGA Data PortalSART1 
Broad Tumor PortalSART1
OASIS PortalSART1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSART1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSART1
Mutations and Diseases : HGMDSART1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSART1
DgiDB (Drug Gene Interaction Database)SART1
DoCM (Curated mutations)SART1
CIViC (Clinical Interpretations of Variants in Cancer)SART1
Cancer3DSART1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605941   
Orphanet
DisGeNETSART1
MedgenSART1
Genetic Testing Registry SART1
NextProtO43290 [Medical]
GENETestsSART1
Target ValidationSART1
Huge Navigator SART1 [HugePedia]
ClinGenSART1
Clinical trials, drugs, therapy
MyCancerGenomeSART1
Protein Interactions : CTDSART1
Pharm GKB GenePA34947
PharosO43290
Clinical trialSART1
Miscellaneous
canSAR (ICR)SART1
HarmonizomeSART1
DataMed IndexSART1
Probes
Litterature
PubMed129 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSART1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:30:05 CEST 2021

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