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SART3 (spliceosome associated factor 3, U4/U6 recycling protein)

Identity

Alias (NCBI)DSAP1
P100
RP11-13G14
TIP110
p110
p110(nrb)
HGNC (Hugo) SART3
HGNC Alias symbKIAA0156
RP11-13G14
TIP110
p110
HGNC Alias nameHIV-1 Tat-interacting protein of 110kDa
 PRP24 homolog
HGNC Previous namesquamous cell carcinoma antigen recognized by T-cells 3
 squamous cell carcinoma antigen recognized by T cells 3
LocusID (NCBI) 9733
Atlas_Id 42205
Location 12q23.3  [Link to chromosome band 12q23]
Location_base_pair Starts at 108522214 and ends at 108561173 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC12 (3p21.31) / SART3 (12q23.3)CDHR5 (11p15.5) / SART3 (12q23.3)REST (4q12) / SART3 (12q23.3)
SART3 (12q23.3) / CORO1C (12q24.11)SART3 (12q23.3) / GTF3A (13q12.2)SART3 (12q23.3) / PDGFRB (5q32)
SART3 (12q23.3) / SART3 (12q23.3)WDR74 (11q12.3) / SART3 (12q23.3)SART3 12q23.3 / CORO1C 12q24.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;12)(q32;q23) SART3/PDGFRB


External links

 

Nomenclature
HGNC (Hugo)SART3   16860
Cards
Entrez_Gene (NCBI)SART3    spliceosome associated factor 3, U4/U6 recycling protein
AliasesDSAP1; P100; RP11-13G14; TIP110; 
p110; p110(nrb)
GeneCards (Weizmann)SART3
Ensembl hg19 (Hinxton)ENSG00000075856 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075856 [Gene_View]  ENSG00000075856 [Sequence]  chr12:108522214-108561173 [Contig_View]  SART3 [Vega]
ICGC DataPortalENSG00000075856
TCGA cBioPortalSART3
AceView (NCBI)SART3
Genatlas (Paris)SART3
SOURCE (Princeton)SART3
Genetics Home Reference (NIH)SART3
Genomic and cartography
GoldenPath hg38 (UCSC)SART3  -     chr12:108522214-108561173 -  12q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SART3  -     12q23.3   [Description]    (hg19-Feb_2009)
GoldenPathSART3 - 12q23.3 [CytoView hg19]  SART3 - 12q23.3 [CytoView hg38]
ImmunoBaseENSG00000075856
Genome Data Viewer NCBISART3 [Mapview hg19]  
OMIM611684   
Gene and transcription
Genbank (Entrez)AB020880 AB073647 AF387506 AI656011 AK225174
RefSeq transcript (Entrez)NM_014706
Consensus coding sequences : CCDS (NCBI)SART3
Gene ExpressionSART3 [ NCBI-GEO ]   SART3 [ EBI - ARRAY_EXPRESS ]   SART3 [ SEEK ]   SART3 [ MEM ]
Gene Expression Viewer (FireBrowse)SART3 [ Firebrowse - Broad ]
GenevisibleExpression of SART3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9733
GTEX Portal (Tissue expression)SART3
Human Protein AtlasENSG00000075856-SART3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15020   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15020  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15020
PhosPhoSitePlusQ15020
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)HAT    LSM_interact    Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom    SART3_RRM1    SART3_RRM2    TPR-like_helical_dom_sf   
Domain families : Pfam (Sanger)Lsm_interact (PF05391)    RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam05391    pfam00076   
Domain families : Smart (EMBL)HAT (SM00386)  RRM (SM00360)  
Conserved Domain (NCBI)SART3
PDB (RSDB)2DO4    5CTQ    5CTR    5CTT    5JJW    5JJX    5JPZ   
PDB Europe2DO4    5CTQ    5CTR    5CTT    5JJW    5JJX    5JPZ   
PDB (PDBSum)2DO4    5CTQ    5CTR    5CTT    5JJW    5JJX    5JPZ   
PDB (IMB)2DO4    5CTQ    5CTR    5CTT    5JJW    5JJX    5JPZ   
Structural Biology KnowledgeBase2DO4    5CTQ    5CTR    5CTT    5JJW    5JJX    5JPZ   
SCOP (Structural Classification of Proteins)2DO4    5CTQ    5CTR    5CTT    5JJW    5JJX    5JPZ   
CATH (Classification of proteins structures)2DO4    5CTQ    5CTR    5CTT    5JJW    5JJX    5JPZ   
SuperfamilyQ15020
AlphaFold pdb e-kbQ15020   
Human Protein Atlas [tissue]ENSG00000075856-SART3 [tissue]
HPRD11532
Protein Interaction databases
DIP (DOE-UCLA)Q15020
IntAct (EBI)Q15020
BioGRIDSART3
STRING (EMBL)SART3
ZODIACSART3
Ontologies - Pathways
QuickGOQ15020
Ontology : AmiGOspliceosomal tri-snRNP complex assembly  spliceosomal snRNP assembly  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  cell morphogenesis  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  nucleosome assembly  regulation of gene expression  Cajal body  nuclear speck  U6 snRNA binding  U4 snRNA binding  U4 snRNA binding  U6atac snRNA binding  histone binding  homeostasis of number of cells  ASAP complex  hematopoietic stem cell proliferation  positive regulation of histone deubiquitination  ubiquitin-specific protease binding  
Ontology : EGO-EBIspliceosomal tri-snRNP complex assembly  spliceosomal snRNP assembly  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  cell morphogenesis  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  nucleosome assembly  regulation of gene expression  Cajal body  nuclear speck  U6 snRNA binding  U4 snRNA binding  U4 snRNA binding  U6atac snRNA binding  histone binding  homeostasis of number of cells  ASAP complex  hematopoietic stem cell proliferation  positive regulation of histone deubiquitination  ubiquitin-specific protease binding  
NDEx NetworkSART3
Atlas of Cancer Signalling NetworkSART3
Wikipedia pathwaysSART3
Orthology - Evolution
OrthoDB9733
GeneTree (enSembl)ENSG00000075856
Phylogenetic Trees/Animal Genes : TreeFamSART3
Homologs : HomoloGeneSART3
Homology/Alignments : Family Browser (UCSC)SART3
Gene fusions - Rearrangements
Fusion : MitelmanSART3/CORO1C [12q23.3/12q24.11]  
Fusion : MitelmanSART3/PDGFRB [12q23.3/5q32]  
Fusion : QuiverSART3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSART3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SART3
dbVarSART3
ClinVarSART3
MonarchSART3
1000_GenomesSART3 
Exome Variant ServerSART3
GNOMAD BrowserENSG00000075856
Varsome BrowserSART3
ACMGSART3 variants
VarityQ15020
Genomic Variants (DGV)SART3 [DGVbeta]
DECIPHERSART3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSART3 
Mutations
ICGC Data PortalSART3 
TCGA Data PortalSART3 
Broad Tumor PortalSART3
OASIS PortalSART3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSART3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSART3
Mutations and Diseases : HGMDSART3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSART3
DgiDB (Drug Gene Interaction Database)SART3
DoCM (Curated mutations)SART3
CIViC (Clinical Interpretations of Variants in Cancer)SART3
Cancer3DSART3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611684   
Orphanet
DisGeNETSART3
MedgenSART3
Genetic Testing Registry SART3
NextProtQ15020 [Medical]
GENETestsSART3
Target ValidationSART3
Huge Navigator SART3 [HugePedia]
ClinGenSART3
Clinical trials, drugs, therapy
MyCancerGenomeSART3
Protein Interactions : CTDSART3
Pharm GKB GenePA34948
PharosQ15020
Clinical trialSART3
Miscellaneous
canSAR (ICR)SART3
HarmonizomeSART3
DataMed IndexSART3
Probes
Litterature
PubMed126 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSART3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:30:05 CEST 2021

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