SAT2 (spermidine/spermine N1-acetyltransferase family member 2)

2007-06-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
SSAT-2,SSAT2

Other Information

Locus ID:

NCBI: 112483
MIM: 611463
HGNC: 23160
Ensembl: ENSG00000141504

Variants:

dbSNP: 112483
ClinVar: 112483
TCGA: ENSG00000141504
COSMIC: SAT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141504ENST00000269298Q96F10
ENSG00000141504ENST00000571074I3L2W7
ENSG00000141504ENST00000573566I3L0W4
ENSG00000141504ENST00000575826I3L2W7

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
GABA biosynthesis, eukaryotes, putrescine => GABAKEGGhsa_M00135
GABA biosynthesis, eukaryotes, putrescine => GABAKEGGM00135
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
178756442007Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.36
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
175580232007Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha.30
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
196251762009PTEN identified as important risk factor of chronic obstructive pulmonary disease.12
191701962009Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.5
165965692006Crystal structure of Homo sapiens thialysine Nepsilon-acetyltransferase (HsSSAT2) in complex with acetyl coenzyme A.4
189494262008Adenovirus-mediated expression of spermidine/spermine N1-acetyltransferase gene induces S-phase arrest in human colorectal cancer cells.3
171198502007Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR.1

Citation

Dessen P

SAT2 (spermidine/spermine N1-acetyltransferase family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01

Online version: http://atlasgeneticsoncology.org/gene/47569/sat2