Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SATB2 (SATB homeobox 2)

Identity

Alias_namesSATB family member 2
Alias_symbol (synonym)KIAA1034
FLJ21474
Other aliasGLSS
HGNC (Hugo) SATB2
LocusID (NCBI) 23314
Atlas_Id 46117
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 199269500 and ends at 199471266 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HDAC4 (2q37.3) / SATB2 (2q33.1)SATB2 (2q33.1) / PIK3C2B (1q32.1)SATB2 (2q33.1) / SATB2 (2q33.1)
HDAC4 2q37.3 / SATB2 2q33.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;2)(q33;q37) HDAC4/SATB2

External links

Nomenclature
HGNC (Hugo)SATB2   21637
Cards
Entrez_Gene (NCBI)SATB2  23314  SATB homeobox 2
AliasesGLSS
GeneCards (Weizmann)SATB2
Ensembl hg19 (Hinxton)ENSG00000119042 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119042 [Gene_View]  chr2:199269500-199471266 [Contig_View]  SATB2 [Vega]
ICGC DataPortalENSG00000119042
TCGA cBioPortalSATB2
AceView (NCBI)SATB2
Genatlas (Paris)SATB2
WikiGenes23314
SOURCE (Princeton)SATB2
Genetics Home Reference (NIH)SATB2
Genomic and cartography
GoldenPath hg38 (UCSC)SATB2  -     chr2:199269500-199471266 -  2q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SATB2  -     2q33.1   [Description]    (hg19-Feb_2009)
EnsemblSATB2 - 2q33.1 [CytoView hg19]  SATB2 - 2q33.1 [CytoView hg38]
Mapping of homologs : NCBISATB2 [Mapview hg19]  SATB2 [Mapview hg38]
OMIM608148   612313   
Gene and transcription
Genbank (Entrez)AB028957 AB209376 AJ438951 AK025127 AK056638
RefSeq transcript (Entrez)NM_001172509 NM_001172517 NM_015265
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SATB2
Cluster EST : UnigeneHs.516617 [ NCBI ]
CGAP (NCI)Hs.516617
Alternative Splicing GalleryENSG00000119042
Gene ExpressionSATB2 [ NCBI-GEO ]   SATB2 [ EBI - ARRAY_EXPRESS ]   SATB2 [ SEEK ]   SATB2 [ MEM ]
Gene Expression Viewer (FireBrowse)SATB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23314
GTEX Portal (Tissue expression)SATB2
Human Protein AtlasENSG00000119042-SATB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UPW6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UPW6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UPW6
Splice isoforms : SwissVarQ9UPW6
PhosPhoSitePlusQ9UPW6
Domaine pattern : Prosite (Expaxy)CUT (PS51042)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)CUT_dom    CUTL    Homeobox-like    Homeobox_dom    Lambda_DNA-bd_dom    ULD   
Domain families : Pfam (Sanger)CUT (PF02376)    CUTL (PF16557)    Homeobox (PF00046)    ULD (PF16534)   
Domain families : Pfam (NCBI)pfam02376    pfam16557    pfam00046    pfam16534   
Domain families : Smart (EMBL)CUT (SM01109)  HOX (SM00389)  
Conserved Domain (NCBI)SATB2
DMDM Disease mutations23314
Blocks (Seattle)SATB2
PDB (SRS)1WI3    1WIZ    2CSF   
PDB (PDBSum)1WI3    1WIZ    2CSF   
PDB (IMB)1WI3    1WIZ    2CSF   
PDB (RSDB)1WI3    1WIZ    2CSF   
Structural Biology KnowledgeBase1WI3    1WIZ    2CSF   
SCOP (Structural Classification of Proteins)1WI3    1WIZ    2CSF   
CATH (Classification of proteins structures)1WI3    1WIZ    2CSF   
SuperfamilyQ9UPW6
Human Protein Atlas [tissue]ENSG00000119042-SATB2 [tissue]
Peptide AtlasQ9UPW6
HPRD12178
IPIIPI00010433   IPI00386234   IPI00924512   IPI00926670   IPI00651702   
Protein Interaction databases
DIP (DOE-UCLA)Q9UPW6
IntAct (EBI)Q9UPW6
FunCoupENSG00000119042
BioGRIDSATB2
STRING (EMBL)SATB2
ZODIACSATB2
Ontologies - Pathways
QuickGOQ9UPW6
Ontology : AmiGOhistone deacetylase complex  negative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding  neuron migration  osteoblast development  chromatin binding  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  chromatin remodeling  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  embryonic pattern specification  nuclear matrix  covalent chromatin modification  commitment of neuronal cell to specific neuron type in forebrain  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  embryonic skeletal system morphogenesis  cartilage development  palate development  cellular response to organic substance  
Ontology : EGO-EBIhistone deacetylase complex  negative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding  neuron migration  osteoblast development  chromatin binding  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  chromatin remodeling  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  embryonic pattern specification  nuclear matrix  covalent chromatin modification  commitment of neuronal cell to specific neuron type in forebrain  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  embryonic skeletal system morphogenesis  cartilage development  palate development  cellular response to organic substance  
NDEx NetworkSATB2
Atlas of Cancer Signalling NetworkSATB2
Wikipedia pathwaysSATB2
Orthology - Evolution
OrthoDB23314
GeneTree (enSembl)ENSG00000119042
Phylogenetic Trees/Animal Genes : TreeFamSATB2
HOVERGENQ9UPW6
HOGENOMQ9UPW6
Homologs : HomoloGeneSATB2
Homology/Alignments : Family Browser (UCSC)SATB2
Gene fusions - Rearrangements
Fusion : MitelmanHDAC4/SATB2 [2q37.3/2q33.1]  [t(2;2)(q33;q37)]  
Fusion: TCGA_MDACCHDAC4 2q37.3 SATB2 2q33.1 BLCA
Fusion PortalHDAC4 2q37.3 SATB2 2q33.1 BLCA
Fusion : QuiverSATB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSATB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SATB2
dbVarSATB2
ClinVarSATB2
1000_GenomesSATB2 
Exome Variant ServerSATB2
ExAC (Exome Aggregation Consortium)ENSG00000119042
GNOMAD BrowserENSG00000119042
Genetic variants : HAPMAP23314
Genomic Variants (DGV)SATB2 [DGVbeta]
DECIPHERSATB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSATB2 
Mutations
ICGC Data PortalSATB2 
TCGA Data PortalSATB2 
Broad Tumor PortalSATB2
OASIS PortalSATB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSATB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSATB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SATB2
DgiDB (Drug Gene Interaction Database)SATB2
DoCM (Curated mutations)SATB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SATB2 (select a term)
intoGenSATB2
Cancer3DSATB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608148    612313   
Orphanet19604    19605   
DisGeNETSATB2
MedgenSATB2
Genetic Testing Registry SATB2
NextProtQ9UPW6 [Medical]
TSGene23314
GENETestsSATB2
Target ValidationSATB2
Huge Navigator SATB2 [HugePedia]
snp3D : Map Gene to Disease23314
BioCentury BCIQSATB2
ClinGenSATB2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23314
Chemical/Pharm GKB GenePA128394624
Clinical trialSATB2
Miscellaneous
canSAR (ICR)SATB2 (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSATB2
EVEXSATB2
GoPubMedSATB2
iHOPSATB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jun 18 19:43:48 CEST 2018
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