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SBK1 (SH3 domain binding kinase 1)

Identity

Alias_namesSH3-binding domain kinase 1
Alias_symbol (synonym)Sbk
Other aliasSBK
HGNC (Hugo) SBK1
LocusID (NCBI) 388228
Atlas_Id 52478
Location 16p12.1  [Link to chromosome band 16p12]
Location_base_pair Starts at 28292519 and ends at 28323849 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HLA-B (6p21.33) / SBK1 (16p11.2)SBK1 (16p11.2) / UNC13A (19p13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SBK1   17699
Cards
Entrez_Gene (NCBI)SBK1  388228  SH3 domain binding kinase 1
AliasesSBK
GeneCards (Weizmann)SBK1
Ensembl hg19 (Hinxton)ENSG00000188322 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188322 [Gene_View]  chr16:28292519-28323849 [Contig_View]  SBK1 [Vega]
ICGC DataPortalENSG00000188322
TCGA cBioPortalSBK1
AceView (NCBI)SBK1
Genatlas (Paris)SBK1
WikiGenes388228
SOURCE (Princeton)SBK1
Genetics Home Reference (NIH)SBK1
Genomic and cartography
GoldenPath hg38 (UCSC)SBK1  -     chr16:28292519-28323849 +  16p12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SBK1  -     16p12.1   [Description]    (hg19-Feb_2009)
EnsemblSBK1 - 16p12.1 [CytoView hg19]  SBK1 - 16p12.1 [CytoView hg38]
Mapping of homologs : NCBISBK1 [Mapview hg19]  SBK1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AL390134 AY874862 BC172295
RefSeq transcript (Entrez)NM_001024401
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SBK1
Cluster EST : UnigeneHs.97837 [ NCBI ]
CGAP (NCI)Hs.97837
Alternative Splicing GalleryENSG00000188322
Gene ExpressionSBK1 [ NCBI-GEO ]   SBK1 [ EBI - ARRAY_EXPRESS ]   SBK1 [ SEEK ]   SBK1 [ MEM ]
Gene Expression Viewer (FireBrowse)SBK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)388228
GTEX Portal (Tissue expression)SBK1
Human Protein AtlasENSG00000188322-SBK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ52WX2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ52WX2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ52WX2
Splice isoforms : SwissVarQ52WX2
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ52WX2
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Ser/Thr_kinase_AS    Ser/Thr_kinase_Sbk1   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)SBK1
DMDM Disease mutations388228
Blocks (Seattle)SBK1
SuperfamilyQ52WX2
Human Protein Atlas [tissue]ENSG00000188322-SBK1 [tissue]
Peptide AtlasQ52WX2
HPRD18608
IPIIPI00399180   
Protein Interaction databases
DIP (DOE-UCLA)Q52WX2
IntAct (EBI)Q52WX2
FunCoupENSG00000188322
BioGRIDSBK1
STRING (EMBL)SBK1
ZODIACSBK1
Ontologies - Pathways
QuickGOQ52WX2
Ontology : AmiGOprotein serine/threonine kinase activity  ATP binding  cytoplasm  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  
Ontology : EGO-EBIprotein serine/threonine kinase activity  ATP binding  cytoplasm  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  
NDEx NetworkSBK1
Atlas of Cancer Signalling NetworkSBK1
Wikipedia pathwaysSBK1
Orthology - Evolution
OrthoDB388228
GeneTree (enSembl)ENSG00000188322
Phylogenetic Trees/Animal Genes : TreeFamSBK1
HOVERGENQ52WX2
HOGENOMQ52WX2
Homologs : HomoloGeneSBK1
Homology/Alignments : Family Browser (UCSC)SBK1
Gene fusions - Rearrangements
Tumor Fusion PortalSBK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSBK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SBK1
dbVarSBK1
ClinVarSBK1
1000_GenomesSBK1 
Exome Variant ServerSBK1
ExAC (Exome Aggregation Consortium)ENSG00000188322
GNOMAD BrowserENSG00000188322
Genetic variants : HAPMAP388228
Genomic Variants (DGV)SBK1 [DGVbeta]
DECIPHERSBK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSBK1 
Mutations
ICGC Data PortalSBK1 
TCGA Data PortalSBK1 
Broad Tumor PortalSBK1
OASIS PortalSBK1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDSBK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SBK1
DgiDB (Drug Gene Interaction Database)SBK1
DoCM (Curated mutations)SBK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SBK1 (select a term)
intoGenSBK1
Cancer3DSBK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETSBK1
MedgenSBK1
Genetic Testing Registry SBK1
NextProtQ52WX2 [Medical]
TSGene388228
GENETestsSBK1
Target ValidationSBK1
Huge Navigator SBK1 [HugePedia]
snp3D : Map Gene to Disease388228
BioCentury BCIQSBK1
ClinGenSBK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD388228
Chemical/Pharm GKB GenePA134887617
Clinical trialSBK1
Miscellaneous
canSAR (ICR)SBK1 (select the gene name)
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSBK1
EVEXSBK1
GoPubMedSBK1
iHOPSBK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:33:33 CET 2017

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