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SCARB1 (scavenger receptor class B member 1)

Identity

Alias_namesCD36L1
CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
scavenger receptor class B, member 1
Alias_symbol (synonym)SRB1
CLA-1
CLA1
SR-BI
Other aliasHDLQTL6
HGNC (Hugo) SCARB1
LocusID (NCBI) 949
Atlas_Id 47534
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 124777628 and ends at 124863973 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
APBB1IP (10p12.1) / SCARB1 (12q24.31)NCOR2 (12q24.31) / SCARB1 (12q24.31)ROBO3 (11q24.2) / SCARB1 (12q24.31)
SCARB1 (12q24.31) / DHX37 (12q24.31)SCARB1 (12q24.31) / SUB1 (5p13.3)SCARB1 (12q24.31) / TMEM9 (1q32.1)
SCARB1 (12q24.31) / UBC (12q24.31)NCOR2 12q24.31 / SCARB1 12q24.31SCARB1 12q24.31 / DHX37 12q24.31
SCARB1 12q24.31 / SUB1 5p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)SCARB1   1664
Cards
Entrez_Gene (NCBI)SCARB1  949  scavenger receptor class B member 1
AliasesCD36L1; CLA-1; CLA1; HDLQTL6; 
SR-BI; SRB1
GeneCards (Weizmann)SCARB1
Ensembl hg19 (Hinxton)ENSG00000073060 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000073060 [Gene_View]  chr12:124777628-124863973 [Contig_View]  SCARB1 [Vega]
ICGC DataPortalENSG00000073060
TCGA cBioPortalSCARB1
AceView (NCBI)SCARB1
Genatlas (Paris)SCARB1
WikiGenes949
SOURCE (Princeton)SCARB1
Genetics Home Reference (NIH)SCARB1
Genomic and cartography
GoldenPath hg38 (UCSC)SCARB1  -     chr12:124777628-124863973 -  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCARB1  -     12q24.31   [Description]    (hg19-Feb_2009)
EnsemblSCARB1 - 12q24.31 [CytoView hg19]  SCARB1 - 12q24.31 [CytoView hg38]
Mapping of homologs : NCBISCARB1 [Mapview hg19]  SCARB1 [Mapview hg38]
OMIM601040   610762   
Gene and transcription
Genbank (Entrez)AB209436 AF254409 AF515445 AK124112 AK302779
RefSeq transcript (Entrez)NM_001082959 NM_005505
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SCARB1
Cluster EST : UnigeneHs.731377 [ NCBI ]
CGAP (NCI)Hs.731377
Alternative Splicing GalleryENSG00000073060
Gene ExpressionSCARB1 [ NCBI-GEO ]   SCARB1 [ EBI - ARRAY_EXPRESS ]   SCARB1 [ SEEK ]   SCARB1 [ MEM ]
Gene Expression Viewer (FireBrowse)SCARB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)949
GTEX Portal (Tissue expression)SCARB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WTV0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WTV0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WTV0
Splice isoforms : SwissVarQ8WTV0
PhosPhoSitePlusQ8WTV0
Domains : Interpro (EBI)CD36/SCARB1/SNMP1    CD36_fam   
Domain families : Pfam (Sanger)CD36 (PF01130)   
Domain families : Pfam (NCBI)pfam01130   
Conserved Domain (NCBI)SCARB1
DMDM Disease mutations949
Blocks (Seattle)SCARB1
SuperfamilyQ8WTV0
Human Protein AtlasENSG00000073060
Peptide AtlasQ8WTV0
HPRD03024
IPIIPI00291007   IPI00177968   IPI00375570   IPI00447020   IPI01011638   IPI00815756   IPI00980369   IPI00939960   IPI01008855   IPI01009964   IPI01009204   
Protein Interaction databases
DIP (DOE-UCLA)Q8WTV0
IntAct (EBI)Q8WTV0
FunCoupENSG00000073060
BioGRIDSCARB1
STRING (EMBL)SCARB1
ZODIACSCARB1
Ontologies - Pathways
QuickGOQ8WTV0
Ontology : AmiGOlipopolysaccharide binding  virus receptor activity  phosphatidylserine binding  lipopolysaccharide receptor activity  endothelial cell proliferation  transporter activity  protein binding  1-phosphatidylinositol binding  lysosomal membrane  plasma membrane  plasma membrane  integral component of plasma membrane  caveola  androgen biosynthetic process  cholesterol catabolic process  receptor-mediated endocytosis  high-density lipoprotein particle binding  cell surface  positive regulation of endothelial cell migration  positive regulation of triglyceride biosynthetic process  positive regulation of cholesterol storage  regulation of phosphatidylcholine catabolic process  phospholipid transport  lipopolysaccharide transport  low-density lipoprotein particle binding  endocytic vesicle membrane  microvillus membrane  lipopolysaccharide-mediated signaling pathway  detection of lipopolysaccharide  cholesterol efflux  cholesterol efflux  apolipoprotein binding  apolipoprotein A-I binding  high-density lipoprotein particle remodeling  low-density lipoprotein particle clearance  high-density lipoprotein particle clearance  vitamin transmembrane transport  wound healing  lipoprotein metabolic process  cholesterol homeostasis  protein homodimerization activity  intracellular membrane-bounded organelle  blood vessel endothelial cell migration  recognition of apoptotic cell  reverse cholesterol transport  adhesion of symbiont to host  viral entry into host cell  regulation of phagocytosis  intestinal absorption  positive regulation of nitric-oxide synthase activity  extracellular exosome  triglyceride homeostasis  high-density lipoprotein particle receptor activity  high-density lipoprotein particle receptor activity  cholesterol import  cholesterol import  
Ontology : EGO-EBIlipopolysaccharide binding  virus receptor activity  phosphatidylserine binding  lipopolysaccharide receptor activity  endothelial cell proliferation  transporter activity  protein binding  1-phosphatidylinositol binding  lysosomal membrane  plasma membrane  plasma membrane  integral component of plasma membrane  caveola  androgen biosynthetic process  cholesterol catabolic process  receptor-mediated endocytosis  high-density lipoprotein particle binding  cell surface  positive regulation of endothelial cell migration  positive regulation of triglyceride biosynthetic process  positive regulation of cholesterol storage  regulation of phosphatidylcholine catabolic process  phospholipid transport  lipopolysaccharide transport  low-density lipoprotein particle binding  endocytic vesicle membrane  microvillus membrane  lipopolysaccharide-mediated signaling pathway  detection of lipopolysaccharide  cholesterol efflux  cholesterol efflux  apolipoprotein binding  apolipoprotein A-I binding  high-density lipoprotein particle remodeling  low-density lipoprotein particle clearance  high-density lipoprotein particle clearance  vitamin transmembrane transport  wound healing  lipoprotein metabolic process  cholesterol homeostasis  protein homodimerization activity  intracellular membrane-bounded organelle  blood vessel endothelial cell migration  recognition of apoptotic cell  reverse cholesterol transport  adhesion of symbiont to host  viral entry into host cell  regulation of phagocytosis  intestinal absorption  positive regulation of nitric-oxide synthase activity  extracellular exosome  triglyceride homeostasis  high-density lipoprotein particle receptor activity  high-density lipoprotein particle receptor activity  cholesterol import  cholesterol import  
Pathways : KEGGPhagosome    Ovarian steroidogenesis    Fat digestion and absorption    Bile secretion    Vitamin digestion and absorption    Hepatitis C   
NDEx NetworkSCARB1
Atlas of Cancer Signalling NetworkSCARB1
Wikipedia pathwaysSCARB1
Orthology - Evolution
OrthoDB949
GeneTree (enSembl)ENSG00000073060
Phylogenetic Trees/Animal Genes : TreeFamSCARB1
HOVERGENQ8WTV0
HOGENOMQ8WTV0
Homologs : HomoloGeneSCARB1
Homology/Alignments : Family Browser (UCSC)SCARB1
Gene fusions - Rearrangements
Fusion : MitelmanNCOR2/SCARB1 [12q24.31/12q24.31]  [t(12;12)(q24;q24)]  
Fusion : MitelmanSCARB1/DHX37 [12q24.31/12q24.31]  [t(12;12)(q24;q24)]  
Fusion : MitelmanSCARB1/SUB1 [12q24.31/5p13.3]  [t(5;12)(p13;q24)]  
Fusion: TCGANCOR2 12q24.31 SCARB1 12q24.31 BRCA LAML LUAD
Fusion: TCGASCARB1 12q24.31 DHX37 12q24.31 BRCA
Fusion: TCGASCARB1 12q24.31 SUB1 5p13.3 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCARB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SCARB1
dbVarSCARB1
ClinVarSCARB1
1000_GenomesSCARB1 
Exome Variant ServerSCARB1
ExAC (Exome Aggregation Consortium)SCARB1 (select the gene name)
Genetic variants : HAPMAP949
Genomic Variants (DGV)SCARB1 [DGVbeta]
DECIPHERSCARB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCARB1 
Mutations
ICGC Data PortalSCARB1 
TCGA Data PortalSCARB1 
Broad Tumor PortalSCARB1
OASIS PortalSCARB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCARB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSCARB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SCARB1
DgiDB (Drug Gene Interaction Database)SCARB1
DoCM (Curated mutations)SCARB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SCARB1 (select a term)
intoGenSCARB1
Cancer3DSCARB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601040    610762   
Orphanet
MedgenSCARB1
Genetic Testing Registry SCARB1
NextProtQ8WTV0 [Medical]
TSGene949
GENETestsSCARB1
Huge Navigator SCARB1 [HugePedia]
snp3D : Map Gene to Disease949
BioCentury BCIQSCARB1
ClinGenSCARB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD949
Chemical/Pharm GKB GenePA97
Clinical trialSCARB1
Miscellaneous
canSAR (ICR)SCARB1 (select the gene name)
Probes
Litterature
PubMed271 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSCARB1
EVEXSCARB1
GoPubMedSCARB1
iHOPSCARB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:36:12 CEST 2017

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