SCARB1 (scavenger receptor class B member 1)

2007-05-01  

Identity

HGNC
SCARB1
LOCATION
12q24.31
LOCUSID
949
ALIAS
CD36L1,CLA-1,CLA1,HDLQTL6,SR-BI,SRB1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 949
MIM: 601040
HGNC: 1664
Ensembl: ENSG00000073060

Variants:

dbSNP: 949
ClinVar: 949
TCGA: ENSG00000073060
COSMIC: SCARB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073060ENST00000261693Q8WTV0
ENSG00000073060ENST00000261693A0A024RBS4
ENSG00000073060ENST00000339570Q8WTV0
ENSG00000073060ENST00000415380Q8WTV0
ENSG00000073060ENST00000544327F5H4X0
ENSG00000073060ENST00000545493F5H5E8
ENSG00000073060ENST00000546215B7ZKQ9

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Vitamin digestion and absorptionKEGGko04977
Vitamin digestion and absorptionKEGGhsa04977
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging by Class B ReceptorsREACTOMER-HSA-3000471
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
HDL-mediated lipid transportREACTOMER-HSA-194223
Aldosterone synthesis and secretionKEGGhsa04925
Aldosterone synthesis and secretionKEGGko04925

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164749390peginterferon alfa-2aChemicalClinicalAnnotationassociatedPD
PA444516HypercholesterolemiaDiseaseClinicalAnnotationassociatedPD20064494
PA446120HypertriglyceridemiaDiseaseClinicalAnnotationassociatedPD
PA446863Hepatitis C, ChronicDiseaseClinicalAnnotationassociatedPD
PA448500atorvastatinChemicalClinicalAnnotationassociatedPD20064494
PA449594fenofibrateChemicalClinicalAnnotationassociatedPD
PA451241ribavirinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
206865652010Biological, clinical and population relevance of 95 loci for blood lipids.1468
129130012003Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor.221
191489422009Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs.170
269656212016Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.123
209620762011Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission.101
156321712005High density lipoproteins facilitate hepatitis C virus entry through the scavenger receptor class B type I.88
212265792011Genetic variant of the scavenger receptor BI in humans.88
166754502006High density lipoprotein inhibits hepatitis C virus-neutralizing antibodies by stimulating cell entry via activation of the scavenger receptor BI.85
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
171109152006Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors.80

Citation

Dessen P

SCARB1 (scavenger receptor class B member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-05-01

Online version: http://atlasgeneticsoncology.org/gene/47534/scarb1