SCG2 (secretogranin II)

2007-02-01  

Identity

HGNC
LOCATION
2q36.1
LOCUSID
ALIAS
CHGC,EM66,SN,SgII
FUSION GENES

Other Information

Locus ID:

NCBI: 7857
MIM: 118930
HGNC: 10575
Ensembl: ENSG00000171951

Variants:

dbSNP: 7857
ClinVar: 7857
TCGA: ENSG00000171951
COSMIC: SCG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171951ENST00000305409P13521
ENSG00000171951ENST00000421386C9JQI2
ENSG00000171951ENST00000433889C9JDT0

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
230819902012The angiogenic factor secretoneurin induces coronary angiogenesis in a model of myocardial infarction by stimulation of vascular endothelial growth factor signaling in endothelial cells.28
175847652007An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension.13
184481762008Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours.12
185493512008Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line.10
187218312009Chromogranin peptides in amyotrophic lateral sclerosis.10
234235802013Increased fecal levels of chromogranin A, chromogranin B, and secretoneurin in collagenous colitis.10
205509512010Secretogranin III in human neuroendocrine tumours: a comparative immunohistochemical study with chromogranins A and B and secretogranin II.8
127888582003Identification of the secretogranin II-derived peptide EM66 in pheochromocytomas as a potential marker for discriminating benign versus malignant tumors.7
182396712008Secretogranin II: a key AP-1-regulated protein that mediates neuronal differentiation and protection from nitric oxide-induced apoptosis of neuroblastoma cells.7
239182062014Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF.7

Citation

Dessen P

SCG2 (secretogranin II)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43777/scg2