SCGB2A1 (secretoglobin family 2A member 1)

2003-08-01  

Identity

HGNC
SCGB2A1
LOCATION
11q12.3
LOCUSID
4246
ALIAS
LPHC,LPNC,MGB2,UGB3

Other Information

Locus ID:

NCBI: 4246
MIM: 604398
HGNC: 7051
Ensembl: ENSG00000124939

Variants:

dbSNP: 4246
ClinVar: 4246
TCGA: ENSG00000124939
COSMIC: SCGB2A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124939ENST00000244930O75556

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
233329232013Expression of mammaglobin and gross cystic disease fluid protein-15 in breast carcinomas.16
120228752002Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer.15
161664292005Identification of mammaglobin as a novel serum marker for breast cancer.13
238071632013Mammaglobin B (SCGB2A1) is a novel tumour antigen highly differentially expressed in all major histological types of ovarian cancer: implications for ovarian cancer immunotherapy.12
180212172008Mammaglobin B expression in human endometrial cancer.11
151512032004RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes.9
196351432009Mammaglobin B is an independent prognostic marker in epithelial ovarian cancer and its expression is associated with reduced risk of disease recurrence.9
160204862005Secretoglobin 2A1 is under selective androgen control mediated by a peculiar binding site for Sp family transcription factors.8
245852492014SCGB2A1 is a novel prognostic marker for colorectal cancer associated with chemoresistance and radioresistance.7
259061232016The Novel Marker GATA3 is Significantly More Sensitive Than Traditional Markers Mammaglobin and GCDFP15 for Identifying Breast Cancer in Surgical and Cytology Specimens of Metastatic and Matched Primary Tumors.5

Citation

Dessen P

SCGB2A1 (secretoglobin family 2A member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42212/scgb2a1