SCGN (secretagogin, EF-hand calcium binding protein)

2007-02-01  

Identity

HGNC
SCGN
LOCATION
6p22.2
LOCUSID
10590
ALIAS
CALBL,DJ501N12.8,SECRET,SEGN,setagin
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10590
MIM: 609202
HGNC: 16941
Ensembl: ENSG00000079689

Variants:

dbSNP: 10590
ClinVar: 10590
TCGA: ENSG00000079689
COSMIC: SCGN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000079689ENST00000334979Q96P10
ENSG00000079689ENST00000377961O76038
ENSG00000079689ENST00000612225Q96P10

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
219762362012The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury.34
286377942017A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.19
231024062012Secretagogin is expressed in sensory CGRP neurons and in spinal cord of mouse and complements other calcium-binding proteins, with a note on rat and human.18
205291292010Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon.17
252266152014Overexpression of secretagogin inhibits cell apoptosis and induces chemoresistance in small cell lung cancer under the regulation of miR-494.16
283258942017SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells.11
224743932012Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation.10
282234952017Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration.9
152379302003Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas.8
212885572011Expression of secretagogin in clear-cell renal cell carcinomas is associated with a high metastasis rate.8

Citation

Dessen P

SCGN (secretagogin, EF-hand calcium binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45603/scgn