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SCIN (scinderin)

Identity

Alias_symbol (synonym)KIAA1905
Other alias-
HGNC (Hugo) SCIN
LocusID (NCBI) 85477
Atlas_Id 53852
Location 7p21.3  [Link to chromosome band 7p21]
Location_base_pair Starts at 12570577 and ends at 12653603 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ELMO1 (7p14.2) / SCIN (7p21.3)SCIN (7p21.3) / LOC100505876 ()SCIN (7p21.3) / RNF38 (9p13.2)
VIPR1 (3p22.1) / SCIN (7p21.3)ELMO1 7p14.2 / SCIN 7p21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SCIN   21695
Cards
Entrez_Gene (NCBI)SCIN  85477  scinderin
Aliases
GeneCards (Weizmann)SCIN
Ensembl hg19 (Hinxton)ENSG00000006747 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000006747 [Gene_View]  chr7:12570577-12653603 [Contig_View]  SCIN [Vega]
ICGC DataPortalENSG00000006747
TCGA cBioPortalSCIN
AceView (NCBI)SCIN
Genatlas (Paris)SCIN
WikiGenes85477
SOURCE (Princeton)SCIN
Genetics Home Reference (NIH)SCIN
Genomic and cartography
GoldenPath hg38 (UCSC)SCIN  -     chr7:12570577-12653603 +  7p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCIN  -     7p21.3   [Description]    (hg19-Feb_2009)
EnsemblSCIN - 7p21.3 [CytoView hg19]  SCIN - 7p21.3 [CytoView hg38]
Mapping of homologs : NCBISCIN [Mapview hg19]  SCIN [Mapview hg38]
OMIM613416   
Gene and transcription
Genbank (Entrez)AB067492 AF276507 AK027778 AK075123 AK075198
RefSeq transcript (Entrez)NM_001112706 NM_033128
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SCIN
Cluster EST : UnigeneHs.655515 [ NCBI ]
CGAP (NCI)Hs.655515
Alternative Splicing GalleryENSG00000006747
Gene ExpressionSCIN [ NCBI-GEO ]   SCIN [ EBI - ARRAY_EXPRESS ]   SCIN [ SEEK ]   SCIN [ MEM ]
Gene Expression Viewer (FireBrowse)SCIN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85477
GTEX Portal (Tissue expression)SCIN
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6U3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6U3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6U3
Splice isoforms : SwissVarQ9Y6U3
PhosPhoSitePlusQ9Y6U3
Domains : Interpro (EBI)ADF-H/Gelsolin-like_dom    Adseverin    Gelsolin-like_dom    Villin/Gelsolin   
Domain families : Pfam (Sanger)Gelsolin (PF00626)   
Domain families : Pfam (NCBI)pfam00626   
Domain families : Smart (EMBL)GEL (SM00262)  
Conserved Domain (NCBI)SCIN
DMDM Disease mutations85477
Blocks (Seattle)SCIN
PDB (SRS)3FG6    5A1K    5A1M   
PDB (PDBSum)3FG6    5A1K    5A1M   
PDB (IMB)3FG6    5A1K    5A1M   
PDB (RSDB)3FG6    5A1K    5A1M   
Structural Biology KnowledgeBase3FG6    5A1K    5A1M   
SCOP (Structural Classification of Proteins)3FG6    5A1K    5A1M   
CATH (Classification of proteins structures)3FG6    5A1K    5A1M   
SuperfamilyQ9Y6U3
Human Protein AtlasENSG00000006747
Peptide AtlasQ9Y6U3
HPRD11539
IPIIPI00002606   IPI00044745   IPI00879729   IPI00893274   IPI00893571   IPI00973861   IPI00976138   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6U3
IntAct (EBI)Q9Y6U3
FunCoupENSG00000006747
BioGRIDSCIN
STRING (EMBL)SCIN
ZODIACSCIN
Ontologies - Pathways
QuickGOQ9Y6U3
Ontology : AmiGOphosphatidylserine binding  podosome  actin binding  actin binding  calcium ion binding  calcium ion binding  1-phosphatidylinositol binding  phosphatidylinositol-4,5-bisphosphate binding  cytoplasm  brush border  cell cortex  negative regulation of cell proliferation  calcium ion regulated exocytosis  cell junction  regulation of chondrocyte differentiation  sequestering of actin monomers  cell projection  positive regulation of apoptotic process  actin nucleation  positive regulation of megakaryocyte differentiation  actin filament severing  actin filament binding  positive regulation of secretion  positive regulation of actin nucleation  actin filament capping  extracellular exosome  
Ontology : EGO-EBIphosphatidylserine binding  podosome  actin binding  actin binding  calcium ion binding  calcium ion binding  1-phosphatidylinositol binding  phosphatidylinositol-4,5-bisphosphate binding  cytoplasm  brush border  cell cortex  negative regulation of cell proliferation  calcium ion regulated exocytosis  cell junction  regulation of chondrocyte differentiation  sequestering of actin monomers  cell projection  positive regulation of apoptotic process  actin nucleation  positive regulation of megakaryocyte differentiation  actin filament severing  actin filament binding  positive regulation of secretion  positive regulation of actin nucleation  actin filament capping  extracellular exosome  
Pathways : KEGGFc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton    Viral carcinogenesis   
NDEx NetworkSCIN
Atlas of Cancer Signalling NetworkSCIN
Wikipedia pathwaysSCIN
Orthology - Evolution
OrthoDB85477
GeneTree (enSembl)ENSG00000006747
Phylogenetic Trees/Animal Genes : TreeFamSCIN
HOVERGENQ9Y6U3
HOGENOMQ9Y6U3
Homologs : HomoloGeneSCIN
Homology/Alignments : Family Browser (UCSC)SCIN
Gene fusions - Rearrangements
Fusion : MitelmanELMO1/SCIN [7p14.2/7p21.3]  [t(7;7)(p14;p21)]  
Fusion: TCGAELMO1 7p14.2 SCIN 7p21.3 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCIN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SCIN
dbVarSCIN
ClinVarSCIN
1000_GenomesSCIN 
Exome Variant ServerSCIN
ExAC (Exome Aggregation Consortium)SCIN (select the gene name)
Genetic variants : HAPMAP85477
Genomic Variants (DGV)SCIN [DGVbeta]
DECIPHERSCIN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCIN 
Mutations
ICGC Data PortalSCIN 
TCGA Data PortalSCIN 
Broad Tumor PortalSCIN
OASIS PortalSCIN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCIN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSCIN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SCIN
DgiDB (Drug Gene Interaction Database)SCIN
DoCM (Curated mutations)SCIN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SCIN (select a term)
intoGenSCIN
Cancer3DSCIN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613416   
Orphanet
MedgenSCIN
Genetic Testing Registry SCIN
NextProtQ9Y6U3 [Medical]
TSGene85477
GENETestsSCIN
Target ValidationSCIN
Huge Navigator SCIN [HugePedia]
snp3D : Map Gene to Disease85477
BioCentury BCIQSCIN
ClinGenSCIN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD85477
Chemical/Pharm GKB GenePA134981389
Clinical trialSCIN
Miscellaneous
canSAR (ICR)SCIN (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSCIN
EVEXSCIN
GoPubMedSCIN
iHOPSCIN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:30:08 CEST 2017

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