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SCLY (selenocysteine lyase)

Identity

Alias_symbol (synonym)SCL
Other aliashSCL
HGNC (Hugo) SCLY
LocusID (NCBI) 51540
Atlas_Id 46490
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 238060924 and ends at 238099413 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RPL10 (Xq28) / SCLY (2q37.3)SCLY (2q37.3) / CHURC1-FNTB (14q23.3)SV2A (1q21.2) / SCLY (2q37.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SCLY   18161
Cards
Entrez_Gene (NCBI)SCLY  51540  selenocysteine lyase
AliasesSCL; hSCL
GeneCards (Weizmann)SCLY
Ensembl hg19 (Hinxton)ENSG00000132330 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132330 [Gene_View]  chr2:238060924-238099413 [Contig_View]  SCLY [Vega]
ICGC DataPortalENSG00000132330
TCGA cBioPortalSCLY
AceView (NCBI)SCLY
Genatlas (Paris)SCLY
WikiGenes51540
SOURCE (Princeton)SCLY
Genetics Home Reference (NIH)SCLY
Genomic and cartography
GoldenPath hg38 (UCSC)SCLY  -     chr2:238060924-238099413 +  2q37.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCLY  -     2q37.3   [Description]    (hg19-Feb_2009)
EnsemblSCLY - 2q37.3 [CytoView hg19]  SCLY - 2q37.3 [CytoView hg38]
Mapping of homologs : NCBISCLY [Mapview hg19]  SCLY [Mapview hg38]
OMIM611056   
Gene and transcription
Genbank (Entrez)AB209458 AF175767 AK001377 AK127520 AK293283
RefSeq transcript (Entrez)NM_016510
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SCLY
Cluster EST : UnigeneHs.731909 [ NCBI ]
CGAP (NCI)Hs.731909
Alternative Splicing GalleryENSG00000132330
Gene ExpressionSCLY [ NCBI-GEO ]   SCLY [ EBI - ARRAY_EXPRESS ]   SCLY [ SEEK ]   SCLY [ MEM ]
Gene Expression Viewer (FireBrowse)SCLY [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51540
GTEX Portal (Tissue expression)SCLY
Human Protein AtlasENSG00000132330-SCLY [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96I15   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96I15  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96I15
Splice isoforms : SwissVarQ96I15
PhosPhoSitePlusQ96I15
Domains : Interpro (EBI)Aminotrans_V_dom    Cysteine_dSase    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_major_sub1    PyrdxlP-dep_Trfase_major_sub2   
Domain families : Pfam (Sanger)Aminotran_5 (PF00266)   
Domain families : Pfam (NCBI)pfam00266   
Conserved Domain (NCBI)SCLY
DMDM Disease mutations51540
Blocks (Seattle)SCLY
PDB (SRS)3GZC    3GZD   
PDB (PDBSum)3GZC    3GZD   
PDB (IMB)3GZC    3GZD   
PDB (RSDB)3GZC    3GZD   
Structural Biology KnowledgeBase3GZC    3GZD   
SCOP (Structural Classification of Proteins)3GZC    3GZD   
CATH (Classification of proteins structures)3GZC    3GZD   
SuperfamilyQ96I15
Human Protein Atlas [tissue]ENSG00000132330-SCLY [tissue]
Peptide AtlasQ96I15
HPRD15303
IPIIPI00884890   IPI00909950   IPI00910431   IPI00910775   IPI00556507   IPI00101652   IPI00915946   IPI00917929   IPI00917791   IPI00916322   IPI00916168   IPI00916046   IPI00917153   IPI00917004   IPI00916840   
Protein Interaction databases
DIP (DOE-UCLA)Q96I15
IntAct (EBI)Q96I15
FunCoupENSG00000132330
BioGRIDSCLY
STRING (EMBL)SCLY
ZODIACSCLY
Ontologies - Pathways
QuickGOQ96I15
Ontology : AmiGOselenium compound metabolic process  protein binding  cytosol  cellular amino acid metabolic process  selenocysteine lyase activity  transferase activity  
Ontology : EGO-EBIselenium compound metabolic process  protein binding  cytosol  cellular amino acid metabolic process  selenocysteine lyase activity  transferase activity  
Pathways : KEGGSelenocompound metabolism   
NDEx NetworkSCLY
Atlas of Cancer Signalling NetworkSCLY
Wikipedia pathwaysSCLY
Orthology - Evolution
OrthoDB51540
GeneTree (enSembl)ENSG00000132330
Phylogenetic Trees/Animal Genes : TreeFamSCLY
HOVERGENQ96I15
HOGENOMQ96I15
Homologs : HomoloGeneSCLY
Homology/Alignments : Family Browser (UCSC)SCLY
Gene fusions - Rearrangements
Tumor Fusion PortalSCLY
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCLY [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SCLY
dbVarSCLY
ClinVarSCLY
1000_GenomesSCLY 
Exome Variant ServerSCLY
ExAC (Exome Aggregation Consortium)ENSG00000132330
GNOMAD BrowserENSG00000132330
Genetic variants : HAPMAP51540
Genomic Variants (DGV)SCLY [DGVbeta]
DECIPHERSCLY [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCLY 
Mutations
ICGC Data PortalSCLY 
TCGA Data PortalSCLY 
Broad Tumor PortalSCLY
OASIS PortalSCLY [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCLY  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSCLY
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SCLY
DgiDB (Drug Gene Interaction Database)SCLY
DoCM (Curated mutations)SCLY (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SCLY (select a term)
intoGenSCLY
Cancer3DSCLY(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611056   
Orphanet
DisGeNETSCLY
MedgenSCLY
Genetic Testing Registry SCLY
NextProtQ96I15 [Medical]
TSGene51540
GENETestsSCLY
Target ValidationSCLY
Huge Navigator SCLY [HugePedia]
snp3D : Map Gene to Disease51540
BioCentury BCIQSCLY
ClinGenSCLY
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51540
Chemical/Pharm GKB GenePA134979359
Clinical trialSCLY
Miscellaneous
canSAR (ICR)SCLY (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSCLY
EVEXSCLY
GoPubMedSCLY
iHOPSCLY
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:33:40 CET 2017

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