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SCN10A (sodium voltage-gated channel alpha subunit 10)

Identity

Alias_namessodium channel, voltage-gated, type X, alpha polypeptide
sodium channel, voltage-gated, type X, alpha subunit
sodium channel, voltage gated, type X alpha subunit
Alias_symbol (synonym)Nav1.8
hPN3
SNS
PN3
Other aliasFEPS2
HGNC (Hugo) SCN10A
LocusID (NCBI) 6336
Atlas_Id 73043
Location 3p22.2  [Link to chromosome band 3p22]
Location_base_pair Starts at 38697346 and ends at 38794010 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SCN10A   10582
Cards
Entrez_Gene (NCBI)SCN10A  6336  sodium voltage-gated channel alpha subunit 10
AliasesFEPS2; Nav1.8; PN3; SNS; 
hPN3
GeneCards (Weizmann)SCN10A
Ensembl hg19 (Hinxton)ENSG00000185313 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185313 [Gene_View]  ENSG00000185313 [Sequence]  chr3:38697346-38794010 [Contig_View]  SCN10A [Vega]
ICGC DataPortalENSG00000185313
TCGA cBioPortalSCN10A
AceView (NCBI)SCN10A
Genatlas (Paris)SCN10A
WikiGenes6336
SOURCE (Princeton)SCN10A
Genetics Home Reference (NIH)SCN10A
Genomic and cartography
GoldenPath hg38 (UCSC)SCN10A  -     chr3:38697346-38794010 -  3p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCN10A  -     3p22.2   [Description]    (hg19-Feb_2009)
SCN10A - 3p22.2 [CytoView hg19]  SCN10A - 3p22.2 [CytoView hg38]
Mapping of homologs : NCBISCN10A [Mapview hg19]  SCN10A [Mapview hg38]
OMIM604427   615551   
Gene and transcription
Genbank (Entrez)AF117907 BC172222
RefSeq transcript (Entrez)NM_001293306 NM_001293307 NM_006514
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SCN10A
Cluster EST : UnigeneHs.250443 [ NCBI ]
CGAP (NCI)Hs.250443
Alternative Splicing GalleryENSG00000185313
Gene ExpressionSCN10A [ NCBI-GEO ]   SCN10A [ EBI - ARRAY_EXPRESS ]   SCN10A [ SEEK ]   SCN10A [ MEM ]
Gene Expression Viewer (FireBrowse)SCN10A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6336
GTEX Portal (Tissue expression)SCN10A
Human Protein AtlasENSG00000185313-SCN10A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5Y9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5Y9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5Y9
Splice isoforms : SwissVarQ9Y5Y9
PhosPhoSitePlusQ9Y5Y9
Domains : Interpro (EBI)Channel_four-helix_dom    Ion_trans_dom    Na_channel_a10su    Na_channel_asu    Na_trans_assoc   
Domain families : Pfam (Sanger)Ion_trans (PF00520)    Na_trans_assoc (PF06512)   
Domain families : Pfam (NCBI)pfam00520    pfam06512   
Conserved Domain (NCBI)SCN10A
DMDM Disease mutations6336
Blocks (Seattle)SCN10A
SuperfamilyQ9Y5Y9
Human Protein Atlas [tissue]ENSG00000185313-SCN10A [tissue]
Peptide AtlasQ9Y5Y9
HPRD09188
IPIIPI00872541   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5Y9
IntAct (EBI)Q9Y5Y9
FunCoupENSG00000185313
BioGRIDSCN10A
STRING (EMBL)SCN10A
ZODIACSCN10A
Ontologies - Pathways
QuickGOQ9Y5Y9
Ontology : AmiGOvoltage-gated sodium channel complex  regulation of heart rate  voltage-gated sodium channel activity  sensory perception  neuronal action potential  sensory perception of pain  regulation of ion transmembrane transport  sodium ion transmembrane transport  odontogenesis of dentin-containing tooth  ion channel binding  regulation of cardiac muscle contraction  regulation of postsynaptic membrane potential  regulation of atrial cardiac muscle cell membrane depolarization  extracellular exosome  clathrin complex  membrane depolarization during action potential  AV node cell action potential  bundle of His cell action potential  
Ontology : EGO-EBIvoltage-gated sodium channel complex  regulation of heart rate  voltage-gated sodium channel activity  sensory perception  neuronal action potential  sensory perception of pain  regulation of ion transmembrane transport  sodium ion transmembrane transport  odontogenesis of dentin-containing tooth  ion channel binding  regulation of cardiac muscle contraction  regulation of postsynaptic membrane potential  regulation of atrial cardiac muscle cell membrane depolarization  extracellular exosome  clathrin complex  membrane depolarization during action potential  AV node cell action potential  bundle of His cell action potential  
NDEx NetworkSCN10A
Atlas of Cancer Signalling NetworkSCN10A
Wikipedia pathwaysSCN10A
Orthology - Evolution
OrthoDB6336
GeneTree (enSembl)ENSG00000185313
Phylogenetic Trees/Animal Genes : TreeFamSCN10A
HOGENOMQ9Y5Y9
Homologs : HomoloGeneSCN10A
Homology/Alignments : Family Browser (UCSC)SCN10A
Gene fusions - Rearrangements
Fusion : QuiverSCN10A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCN10A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SCN10A
dbVarSCN10A
ClinVarSCN10A
1000_GenomesSCN10A 
Exome Variant ServerSCN10A
ExAC (Exome Aggregation Consortium)ENSG00000185313
GNOMAD BrowserENSG00000185313
Varsome BrowserSCN10A
Genetic variants : HAPMAP6336
Genomic Variants (DGV)SCN10A [DGVbeta]
DECIPHERSCN10A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCN10A 
Mutations
ICGC Data PortalSCN10A 
TCGA Data PortalSCN10A 
Broad Tumor PortalSCN10A
OASIS PortalSCN10A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCN10A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSCN10A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SCN10A
DgiDB (Drug Gene Interaction Database)SCN10A
DoCM (Curated mutations)SCN10A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SCN10A (select a term)
intoGenSCN10A
Cancer3DSCN10A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604427    615551   
Orphanet21236    8022    10594    11928    11818   
DisGeNETSCN10A
MedgenSCN10A
Genetic Testing Registry SCN10A
NextProtQ9Y5Y9 [Medical]
TSGene6336
GENETestsSCN10A
Target ValidationSCN10A
Huge Navigator SCN10A [HugePedia]
snp3D : Map Gene to Disease6336
BioCentury BCIQSCN10A
ClinGenSCN10A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6336
Chemical/Pharm GKB GenePA35000
Clinical trialSCN10A
Miscellaneous
canSAR (ICR)SCN10A (select the gene name)
DataMed IndexSCN10A
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSCN10A
EVEXSCN10A
GoPubMedSCN10A
iHOPSCN10A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Apr 30 13:55:38 CEST 2019
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