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SCN2B (sodium voltage-gated channel beta subunit 2)

Identity

Alias (NCBI)ATFB14
HGNC (Hugo) SCN2B
HGNC Previous namesodium channel, voltage-gated, type II, beta polypeptide
 sodium channel, voltage-gated, type II, beta
 sodium channel, voltage-gated, type II, beta subunit
 sodium channel, voltage gated, type II beta subunit
LocusID (NCBI) 6327
Atlas_Id 55024
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 118162806 and ends at 118176639 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SCN2B (11q23.3) / PLXNB3 (Xq28)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SCN2B   10589
Cards
Entrez_Gene (NCBI)SCN2B  6327  sodium voltage-gated channel beta subunit 2
AliasesATFB14
GeneCards (Weizmann)SCN2B
Ensembl hg19 (Hinxton)ENSG00000149575 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149575 [Gene_View]  ENSG00000149575 [Sequence]  chr11:118162806-118176639 [Contig_View]  SCN2B [Vega]
ICGC DataPortalENSG00000149575
TCGA cBioPortalSCN2B
AceView (NCBI)SCN2B
Genatlas (Paris)SCN2B
WikiGenes6327
SOURCE (Princeton)SCN2B
Genetics Home Reference (NIH)SCN2B
Genomic and cartography
GoldenPath hg38 (UCSC)SCN2B  -     chr11:118162806-118176639 -  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCN2B  -     11q23.3   [Description]    (hg19-Feb_2009)
GoldenPathSCN2B - 11q23.3 [CytoView hg19]  SCN2B - 11q23.3 [CytoView hg38]
ImmunoBaseENSG00000149575
genome Data Viewer NCBISCN2B [Mapview hg19]  
OMIM601327   615378   
Gene and transcription
Genbank (Entrez)AF007783 AF049498 AF107028 AK090729 AK094643
RefSeq transcript (Entrez)NM_004588
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SCN2B
Alternative Splicing GalleryENSG00000149575
Gene ExpressionSCN2B [ NCBI-GEO ]   SCN2B [ EBI - ARRAY_EXPRESS ]   SCN2B [ SEEK ]   SCN2B [ MEM ]
Gene Expression Viewer (FireBrowse)SCN2B [ Firebrowse - Broad ]
GenevisibleExpression of SCN2B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6327
GTEX Portal (Tissue expression)SCN2B
Human Protein AtlasENSG00000149575-SCN2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60939   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60939  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60939
Splice isoforms : SwissVarO60939
PhosPhoSitePlusO60939
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_V-set    Myelin_P0-rel    SCN2B   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)SCN2B
DMDM Disease mutations6327
Blocks (Seattle)SCN2B
PDB (RSDB)5FDY    5FEB    6J8E    6J8G    6J8H    6J8I    6J8J   
PDB Europe5FDY    5FEB    6J8E    6J8G    6J8H    6J8I    6J8J   
PDB (PDBSum)5FDY    5FEB    6J8E    6J8G    6J8H    6J8I    6J8J   
PDB (IMB)5FDY    5FEB    6J8E    6J8G    6J8H    6J8I    6J8J   
Structural Biology KnowledgeBase5FDY    5FEB    6J8E    6J8G    6J8H    6J8I    6J8J   
SCOP (Structural Classification of Proteins)5FDY    5FEB    6J8E    6J8G    6J8H    6J8I    6J8J   
CATH (Classification of proteins structures)5FDY    5FEB    6J8E    6J8G    6J8H    6J8I    6J8J   
SuperfamilyO60939
Human Protein Atlas [tissue]ENSG00000149575-SCN2B [tissue]
Peptide AtlasO60939
HPRD03208
IPIIPI00000087   
Protein Interaction databases
DIP (DOE-UCLA)O60939
IntAct (EBI)O60939
FunCoupENSG00000149575
BioGRIDSCN2B
STRING (EMBL)SCN2B
ZODIACSCN2B
Ontologies - Pathways
QuickGOO60939
Ontology : AmiGOvoltage-gated sodium channel complex  voltage-gated sodium channel complex  voltage-gated ion channel activity  chemical synaptic transmission  nervous system development  sodium channel regulator activity  sodium ion transmembrane transport  synapse  response to pyrethroid  cardiac muscle contraction  regulation of atrial cardiac muscle cell membrane depolarization  cardiac muscle cell action potential involved in contraction  voltage-gated sodium channel activity involved in cardiac muscle cell action potential  membrane depolarization during cardiac muscle cell action potential  regulation of heart rate by cardiac conduction  regulation of sodium ion transmembrane transporter activity  
Ontology : EGO-EBIvoltage-gated sodium channel complex  voltage-gated sodium channel complex  voltage-gated ion channel activity  chemical synaptic transmission  nervous system development  sodium channel regulator activity  sodium ion transmembrane transport  synapse  response to pyrethroid  cardiac muscle contraction  regulation of atrial cardiac muscle cell membrane depolarization  cardiac muscle cell action potential involved in contraction  voltage-gated sodium channel activity involved in cardiac muscle cell action potential  membrane depolarization during cardiac muscle cell action potential  regulation of heart rate by cardiac conduction  regulation of sodium ion transmembrane transporter activity  
NDEx NetworkSCN2B
Atlas of Cancer Signalling NetworkSCN2B
Wikipedia pathwaysSCN2B
Orthology - Evolution
OrthoDB6327
GeneTree (enSembl)ENSG00000149575
Phylogenetic Trees/Animal Genes : TreeFamSCN2B
HOGENOMO60939
Homologs : HomoloGeneSCN2B
Homology/Alignments : Family Browser (UCSC)SCN2B
Gene fusions - Rearrangements
Fusion : QuiverSCN2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCN2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SCN2B
dbVarSCN2B
ClinVarSCN2B
1000_GenomesSCN2B 
Exome Variant ServerSCN2B
GNOMAD BrowserENSG00000149575
Varsome BrowserSCN2B
Genetic variants : HAPMAP6327
Genomic Variants (DGV)SCN2B [DGVbeta]
DECIPHERSCN2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCN2B 
Mutations
ICGC Data PortalSCN2B 
TCGA Data PortalSCN2B 
Broad Tumor PortalSCN2B
OASIS PortalSCN2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCN2B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSCN2B
Mutations and Diseases : HGMDSCN2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SCN2B
DgiDB (Drug Gene Interaction Database)SCN2B
DoCM (Curated mutations)SCN2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SCN2B (select a term)
intoGenSCN2B
Cancer3DSCN2B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601327    615378   
Orphanet8592   
DisGeNETSCN2B
MedgenSCN2B
Genetic Testing Registry SCN2B
NextProtO60939 [Medical]
TSGene6327
GENETestsSCN2B
Target ValidationSCN2B
Huge Navigator SCN2B [HugePedia]
snp3D : Map Gene to Disease6327
BioCentury BCIQSCN2B
ClinGenSCN2B
Clinical trials, drugs, therapy
Protein Interactions : CTD6327
Pharm GKB GenePA303
Clinical trialSCN2B
Miscellaneous
canSAR (ICR)SCN2B (select the gene name)
HarmonizomeSCN2B
DataMed IndexSCN2B
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSCN2B
EVEXSCN2B
GoPubMedSCN2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:34:43 CEST 2020
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