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SCN4B (sodium voltage-gated channel beta subunit 4)

Identity

Alias_namessodium channel, voltage-gated, type IV, beta
sodium channel, voltage-gated, type IV, beta subunit
sodium channel, voltage gated, type IV beta subunit
Alias_symbol (synonym)LQT10
Other aliasATFB17
Navbeta4
HGNC (Hugo) SCN4B
LocusID (NCBI) 6330
Atlas_Id 73049
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 118133377 and ends at 118152915 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SCN4B (11q23.3) / COL6A1 (21q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SCN4B   10592
LRG (Locus Reference Genomic)LRG_330
Cards
Entrez_Gene (NCBI)SCN4B  6330  sodium voltage-gated channel beta subunit 4
AliasesATFB17; LQT10; Navbeta4
GeneCards (Weizmann)SCN4B
Ensembl hg19 (Hinxton)ENSG00000177098 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177098 [Gene_View]  chr11:118133377-118152915 [Contig_View]  SCN4B [Vega]
ICGC DataPortalENSG00000177098
TCGA cBioPortalSCN4B
AceView (NCBI)SCN4B
Genatlas (Paris)SCN4B
WikiGenes6330
SOURCE (Princeton)SCN4B
Genetics Home Reference (NIH)SCN4B
Genomic and cartography
GoldenPath hg38 (UCSC)SCN4B  -     chr11:118133377-118152915 -  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCN4B  -     11q23.3   [Description]    (hg19-Feb_2009)
EnsemblSCN4B - 11q23.3 [CytoView hg19]  SCN4B - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBISCN4B [Mapview hg19]  SCN4B [Mapview hg38]
OMIM608256   611819   
Gene and transcription
Genbank (Entrez)AK090713 AK092285 AK124886 AK314531 AY149967
RefSeq transcript (Entrez)NM_001142348 NM_001142349 NM_174934
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SCN4B
Cluster EST : UnigeneHs.65239 [ NCBI ]
CGAP (NCI)Hs.65239
Alternative Splicing GalleryENSG00000177098
Gene ExpressionSCN4B [ NCBI-GEO ]   SCN4B [ EBI - ARRAY_EXPRESS ]   SCN4B [ SEEK ]   SCN4B [ MEM ]
Gene Expression Viewer (FireBrowse)SCN4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6330
GTEX Portal (Tissue expression)SCN4B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWT1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWT1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWT1
Splice isoforms : SwissVarQ8IWT1
PhosPhoSitePlusQ8IWT1
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    Ig_V-set    Myelin_P0-rel   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)SCN4B
DMDM Disease mutations6330
Blocks (Seattle)SCN4B
PDB (SRS)4MZ2    4MZ3   
PDB (PDBSum)4MZ2    4MZ3   
PDB (IMB)4MZ2    4MZ3   
PDB (RSDB)4MZ2    4MZ3   
Structural Biology KnowledgeBase4MZ2    4MZ3   
SCOP (Structural Classification of Proteins)4MZ2    4MZ3   
CATH (Classification of proteins structures)4MZ2    4MZ3   
SuperfamilyQ8IWT1
Human Protein AtlasENSG00000177098
Peptide AtlasQ8IWT1
HPRD09749
IPIIPI00217376   IPI00514804   IPI00915300   IPI00915246   
Protein Interaction databases
DIP (DOE-UCLA)Q8IWT1
IntAct (EBI)Q8IWT1
FunCoupENSG00000177098
BioGRIDSCN4B
STRING (EMBL)SCN4B
ZODIACSCN4B
Ontologies - Pathways
QuickGOQ8IWT1
Ontology : AmiGOvoltage-gated sodium channel complex  voltage-gated sodium channel complex  voltage-gated sodium channel activity  sodium ion transport  positive regulation of sodium ion transport  intercalated disc  sodium channel regulator activity  intrinsic component of plasma membrane  sodium ion transmembrane transport  ion channel binding  cardiac muscle contraction  regulation of postsynaptic membrane potential  regulation of ventricular cardiac muscle cell membrane repolarization  cardiac muscle cell action potential involved in contraction  voltage-gated sodium channel activity involved in cardiac muscle cell action potential  membrane depolarization during cardiac muscle cell action potential  AV node cell action potential  regulation of heart rate by cardiac conduction  regulation of sodium ion transmembrane transporter activity  
Ontology : EGO-EBIvoltage-gated sodium channel complex  voltage-gated sodium channel complex  voltage-gated sodium channel activity  sodium ion transport  positive regulation of sodium ion transport  intercalated disc  sodium channel regulator activity  intrinsic component of plasma membrane  sodium ion transmembrane transport  ion channel binding  cardiac muscle contraction  regulation of postsynaptic membrane potential  regulation of ventricular cardiac muscle cell membrane repolarization  cardiac muscle cell action potential involved in contraction  voltage-gated sodium channel activity involved in cardiac muscle cell action potential  membrane depolarization during cardiac muscle cell action potential  AV node cell action potential  regulation of heart rate by cardiac conduction  regulation of sodium ion transmembrane transporter activity  
Pathways : KEGGAdrenergic signaling in cardiomyocytes   
NDEx NetworkSCN4B
Atlas of Cancer Signalling NetworkSCN4B
Wikipedia pathwaysSCN4B
Orthology - Evolution
OrthoDB6330
GeneTree (enSembl)ENSG00000177098
Phylogenetic Trees/Animal Genes : TreeFamSCN4B
HOVERGENQ8IWT1
HOGENOMQ8IWT1
Homologs : HomoloGeneSCN4B
Homology/Alignments : Family Browser (UCSC)SCN4B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCN4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SCN4B
dbVarSCN4B
ClinVarSCN4B
1000_GenomesSCN4B 
Exome Variant ServerSCN4B
ExAC (Exome Aggregation Consortium)SCN4B (select the gene name)
Genetic variants : HAPMAP6330
Genomic Variants (DGV)SCN4B [DGVbeta]
DECIPHERSCN4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCN4B 
Mutations
ICGC Data PortalSCN4B 
TCGA Data PortalSCN4B 
Broad Tumor PortalSCN4B
OASIS PortalSCN4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCN4B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSCN4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
BioMutasearch SCN4B
DgiDB (Drug Gene Interaction Database)SCN4B
DoCM (Curated mutations)SCN4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SCN4B (select a term)
intoGenSCN4B
Cancer3DSCN4B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608256    611819   
Orphanet8592    14727   
MedgenSCN4B
Genetic Testing Registry SCN4B
NextProtQ8IWT1 [Medical]
TSGene6330
GENETestsSCN4B
Target ValidationSCN4B
Huge Navigator SCN4B [HugePedia]
snp3D : Map Gene to Disease6330
BioCentury BCIQSCN4B
ClinGenSCN4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6330
Chemical/Pharm GKB GenePA35007
Clinical trialSCN4B
Miscellaneous
canSAR (ICR)SCN4B (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSCN4B
EVEXSCN4B
GoPubMedSCN4B
iHOPSCN4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:37:21 CEST 2017

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