Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SCN7A (sodium voltage-gated channel alpha subunit 7)

Identity

Alias_namesSCN6A
sodium channel, voltage-gated, type VI, alpha
sodium channel, voltage-gated, type VII, alpha
sodium channel, voltage-gated, type VII, alpha subunit
sodium channel, voltage gated, type VII alpha subunit
Alias_symbol (synonym)Nav2.1
Nav2.2
NaG
Other alias
HGNC (Hugo) SCN7A
LocusID (NCBI) 6332
Atlas_Id 73050
Location 2q24.3  [Link to chromosome band 2q24]
Location_base_pair Starts at 166403573 and ends at 166486971 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SCN7A   10594
Cards
Entrez_Gene (NCBI)SCN7A  6332  sodium voltage-gated channel alpha subunit 7
AliasesNaG; Nav2.1; Nav2.2; SCN6A
GeneCards (Weizmann)SCN7A
Ensembl hg19 (Hinxton)ENSG00000136546 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136546 [Gene_View]  chr2:166403573-166486971 [Contig_View]  SCN7A [Vega]
ICGC DataPortalENSG00000136546
TCGA cBioPortalSCN7A
AceView (NCBI)SCN7A
Genatlas (Paris)SCN7A
WikiGenes6332
SOURCE (Princeton)SCN7A
Genetics Home Reference (NIH)SCN7A
Genomic and cartography
GoldenPath hg38 (UCSC)SCN7A  -     chr2:166403573-166486971 -  2q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCN7A  -     2q24.3   [Description]    (hg19-Feb_2009)
EnsemblSCN7A - 2q24.3 [CytoView hg19]  SCN7A - 2q24.3 [CytoView hg38]
Mapping of homologs : NCBISCN7A [Mapview hg19]  SCN7A [Mapview hg38]
OMIM182392   
Gene and transcription
Genbank (Entrez)AK308450 BC062699 BC141864 CF129950 CK903677
RefSeq transcript (Entrez)NM_002976
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SCN7A
Cluster EST : UnigeneHs.644853 [ NCBI ]
CGAP (NCI)Hs.644853
Alternative Splicing GalleryENSG00000136546
Gene ExpressionSCN7A [ NCBI-GEO ]   SCN7A [ EBI - ARRAY_EXPRESS ]   SCN7A [ SEEK ]   SCN7A [ MEM ]
Gene Expression Viewer (FireBrowse)SCN7A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6332
GTEX Portal (Tissue expression)SCN7A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01118   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01118  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01118
Splice isoforms : SwissVarQ01118
PhosPhoSitePlusQ01118
Domains : Interpro (EBI)Channel_four-helix_dom    Ion_trans_dom    Na_channel_a7su    Na_channel_asu    Na_trans_assoc   
Domain families : Pfam (Sanger)Ion_trans (PF00520)    Na_trans_assoc (PF06512)   
Domain families : Pfam (NCBI)pfam00520    pfam06512   
Conserved Domain (NCBI)SCN7A
DMDM Disease mutations6332
Blocks (Seattle)SCN7A
SuperfamilyQ01118
Human Protein AtlasENSG00000136546
Peptide AtlasQ01118
HPRD08355
IPIIPI00300117   IPI00916977   IPI00917730   IPI00916153   
Protein Interaction databases
DIP (DOE-UCLA)Q01118
IntAct (EBI)Q01118
FunCoupENSG00000136546
BioGRIDSCN7A
STRING (EMBL)SCN7A
ZODIACSCN7A
Ontologies - Pathways
QuickGOQ01118
Ontology : AmiGOvoltage-gated sodium channel complex  voltage-gated sodium channel activity  plasma membrane  sodium ion transport  muscle contraction  neuronal action potential  regulation of ion transmembrane transport  sodium ion transmembrane transport  sodium ion homeostasis  regulation of postsynaptic membrane potential  membrane depolarization during action potential  glial cell projection  
Ontology : EGO-EBIvoltage-gated sodium channel complex  voltage-gated sodium channel activity  plasma membrane  sodium ion transport  muscle contraction  neuronal action potential  regulation of ion transmembrane transport  sodium ion transmembrane transport  sodium ion homeostasis  regulation of postsynaptic membrane potential  membrane depolarization during action potential  glial cell projection  
Pathways : KEGGAdrenergic signaling in cardiomyocytes   
NDEx NetworkSCN7A
Atlas of Cancer Signalling NetworkSCN7A
Wikipedia pathwaysSCN7A
Orthology - Evolution
OrthoDB6332
GeneTree (enSembl)ENSG00000136546
Phylogenetic Trees/Animal Genes : TreeFamSCN7A
HOVERGENQ01118
HOGENOMQ01118
Homologs : HomoloGeneSCN7A
Homology/Alignments : Family Browser (UCSC)SCN7A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCN7A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SCN7A
dbVarSCN7A
ClinVarSCN7A
1000_GenomesSCN7A 
Exome Variant ServerSCN7A
ExAC (Exome Aggregation Consortium)SCN7A (select the gene name)
Genetic variants : HAPMAP6332
Genomic Variants (DGV)SCN7A [DGVbeta]
DECIPHERSCN7A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCN7A 
Mutations
ICGC Data PortalSCN7A 
TCGA Data PortalSCN7A 
Broad Tumor PortalSCN7A
OASIS PortalSCN7A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCN7A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSCN7A
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch SCN7A
DgiDB (Drug Gene Interaction Database)SCN7A
DoCM (Curated mutations)SCN7A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SCN7A (select a term)
intoGenSCN7A
Cancer3DSCN7A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182392   
Orphanet
MedgenSCN7A
Genetic Testing Registry SCN7A
NextProtQ01118 [Medical]
TSGene6332
GENETestsSCN7A
Target ValidationSCN7A
Huge Navigator SCN7A [HugePedia]
snp3D : Map Gene to Disease6332
BioCentury BCIQSCN7A
ClinGenSCN7A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6332
Chemical/Pharm GKB GenePA35008
Clinical trialSCN7A
Miscellaneous
canSAR (ICR)SCN7A (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSCN7A
EVEXSCN7A
GoPubMedSCN7A
iHOPSCN7A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:37:21 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.