SCO1 (synthesis of cytochrome C oxidase 1)

2007-04-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
MC4DN4,SCOD1
FUSION GENES

Other Information

Locus ID:

NCBI: 6341
MIM: 603644
HGNC: 10603
Ensembl: ENSG00000133028

Variants:

dbSNP: 6341
ClinVar: 6341
TCGA: ENSG00000133028
COSMIC: SCO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133028ENST00000255390O75880
ENSG00000133028ENST00000577335J3QR42
ENSG00000133028ENST00000577427J3QL56

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Respiratory electron transportREACTOMER-HSA-611105

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
152291892004Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase.66
171892032007The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis.62
193364782009Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1.59
160913562005Human Sco1 and Sco2 function as copper-binding proteins.55
167354682006A hint for the function of human Sco1 from different structures.37
184583392008Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer.36
192951702009Loss of function of Sco1 and its interaction with cytochrome c oxidase.34
261609152015COA6 is a mitochondrial complex IV assembly factor critical for biogenesis of mtDNA-encoded COX2.33
244030532014Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.30

Citation

Dessen P

SCO1 (synthesis of cytochrome C oxidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47018/sco1