Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SCO2 (synthesis of cytochrome C oxidase 2)

Identity

Alias (NCBI)CEMCOX1
ECGF1
Gliostatin
MC4DN2
MYP6
PD-ECGF
SCO1L
TP
TYMP
TdRPase
HGNC (Hugo) SCO2
HGNC Alias symbSCO1L
HGNC Previous nameMYP6
HGNC Previous nameSCO (cytochrome oxidase deficient, yeast) homolog 2
 SCO cytochrome oxidase deficient homolog 2 (yeast)
 myopia 6
 SCO2, cytochrome c oxidase assembly protein
 SCO cytochrome c oxidase assembly protein 2
LocusID (NCBI) 9997
Atlas_Id 46811
Location 22q13.33  [Link to chromosome band 22q13]
Location_base_pair Starts at 50523568 and ends at 50525598 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SBF1 (22q13.33) / SCO2 (22q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(22;22)(q13;q13) PIM3/SCO2


External links

 

Nomenclature
HGNC (Hugo)SCO2   10604
Cards
Entrez_Gene (NCBI)SCO2    synthesis of cytochrome C oxidase 2
AliasesCEMCOX1; ECGF1; Gliostatin; MC4DN2; 
MYP6; PD-ECGF; SCO1L; TP; TYMP; TdRPase
GeneCards (Weizmann)SCO2
Ensembl hg19 (Hinxton)ENSG00000284194 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000284194 [Gene_View]  ENSG00000284194 [Sequence]  chr22:50523568-50525598 [Contig_View]  SCO2 [Vega]
ICGC DataPortalENSG00000284194
TCGA cBioPortalSCO2
AceView (NCBI)SCO2
Genatlas (Paris)SCO2
SOURCE (Princeton)SCO2
Genetics Home Reference (NIH)SCO2
Genomic and cartography
GoldenPath hg38 (UCSC)SCO2  -     chr22:50523568-50525598 -  22q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCO2  -     22q13.33   [Description]    (hg19-Feb_2009)
GoldenPathSCO2 - 22q13.33 [CytoView hg19]  SCO2 - 22q13.33 [CytoView hg38]
ImmunoBaseENSG00000284194
Genome Data Viewer NCBISCO2 [Mapview hg19]  
OMIM604272   604377   608908   
Gene and transcription
Genbank (Entrez)AL021683 BC102024 BC102025 BG392981 BM787182
RefSeq transcript (Entrez)NM_001169109 NM_001169110 NM_001169111 NM_005138
Consensus coding sequences : CCDS (NCBI)SCO2
Gene ExpressionSCO2 [ NCBI-GEO ]   SCO2 [ EBI - ARRAY_EXPRESS ]   SCO2 [ SEEK ]   SCO2 [ MEM ]
Gene Expression Viewer (FireBrowse)SCO2 [ Firebrowse - Broad ]
GenevisibleExpression of SCO2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9997
GTEX Portal (Tissue expression)SCO2
Human Protein AtlasENSG00000284194-SCO2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43819   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43819  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43819
PhosPhoSitePlusO43819
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)SCO1/SenC    Synth_of_cyt-c-oxidase_Sco1/2    Thioredoxin-like_sf    Thioredoxin_domain   
Domain families : Pfam (Sanger)SCO1-SenC (PF02630)   
Domain families : Pfam (NCBI)pfam02630   
Conserved Domain (NCBI)SCO2
PDB (RSDB)2RLI   
PDB Europe2RLI   
PDB (PDBSum)2RLI   
PDB (IMB)2RLI   
Structural Biology KnowledgeBase2RLI   
SCOP (Structural Classification of Proteins)2RLI   
CATH (Classification of proteins structures)2RLI   
SuperfamilyO43819
AlphaFold pdb e-kbO43819   
Human Protein Atlas [tissue]ENSG00000284194-SCO2 [tissue]
HPRD05042
Protein Interaction databases
DIP (DOE-UCLA)O43819
IntAct (EBI)O43819
BioGRIDSCO2
STRING (EMBL)SCO2
ZODIACSCO2
Ontologies - Pathways
QuickGOO43819
Ontology : AmiGOeye development  in utero embryonic development  muscle system process  copper ion binding  protein binding  mitochondrion  mitochondrion  mitochondrial matrix  cellular copper ion homeostasis  response to activity  protein-disulfide reductase activity  copper chaperone activity  respiratory electron transport chain  myofibril  integral component of mitochondrial inner membrane  mitochondrial cytochrome c oxidase assembly  mitochondrial cytochrome c oxidase assembly  mitochondrial cytochrome c oxidase assembly  
Ontology : EGO-EBIeye development  in utero embryonic development  muscle system process  copper ion binding  protein binding  mitochondrion  mitochondrion  mitochondrial matrix  cellular copper ion homeostasis  response to activity  protein-disulfide reductase activity  copper chaperone activity  respiratory electron transport chain  myofibril  integral component of mitochondrial inner membrane  mitochondrial cytochrome c oxidase assembly  mitochondrial cytochrome c oxidase assembly  mitochondrial cytochrome c oxidase assembly  
NDEx NetworkSCO2
Atlas of Cancer Signalling NetworkSCO2
Wikipedia pathwaysSCO2
Orthology - Evolution
OrthoDB9997
GeneTree (enSembl)ENSG00000284194
Phylogenetic Trees/Animal Genes : TreeFamSCO2
Homologs : HomoloGeneSCO2
Homology/Alignments : Family Browser (UCSC)SCO2
Gene fusions - Rearrangements
Fusion : MitelmanSBF1/SCO2 [22q13.33/22q13.33]  
Fusion : QuiverSCO2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SCO2
dbVarSCO2
ClinVarSCO2
MonarchSCO2
1000_GenomesSCO2 
Exome Variant ServerSCO2
GNOMAD BrowserENSG00000284194
Varsome BrowserSCO2
ACMGSCO2 variants
VarityO43819
Genomic Variants (DGV)SCO2 [DGVbeta]
DECIPHERSCO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCO2 
Mutations
ICGC Data PortalSCO2 
TCGA Data PortalSCO2 
Broad Tumor PortalSCO2
OASIS PortalSCO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCO2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSCO2
Mutations and Diseases : HGMDSCO2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSCO2
DgiDB (Drug Gene Interaction Database)SCO2
DoCM (Curated mutations)SCO2
CIViC (Clinical Interpretations of Variants in Cancer)SCO2
Cancer3DSCO2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604272    604377    608908   
Orphanet3379    10947    13636   
DisGeNETSCO2
MedgenSCO2
Genetic Testing Registry SCO2
NextProtO43819 [Medical]
GENETestsSCO2
Target ValidationSCO2
Huge Navigator SCO2 [HugePedia]
ClinGenSCO2
Clinical trials, drugs, therapy
MyCancerGenomeSCO2
Protein Interactions : CTDSCO2
Pharm GKB GenePA35013
PharosO43819
Clinical trialSCO2
Miscellaneous
canSAR (ICR)SCO2
HarmonizomeSCO2
DataMed IndexSCO2
Probes
Litterature
PubMed89 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSCO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:30:18 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.