Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SCRIB (scribbled planar cell polarity protein)

Identity

Alias_namesscribbled homolog (Drosophila)
Alias_symbol (synonym)KIAA0147
SCRB1
Vartul
Other aliasCRIB1
SCRIB1
HGNC (Hugo) SCRIB
LocusID (NCBI) 23513
Atlas_Id 42218
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 143790920 and ends at 143815379 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		MAPK15 (8q24.3) / SCRIB (8q24.3)SCRIB (8q24.3) / NRBP2 (8q24.3)TMEM185B (2q14.2) / SCRIB (8q24.3)
SCRIB 8q24.3 / NRBP2 8q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SCRIB   30377
Cards
Entrez_Gene (NCBI)SCRIB  23513  scribbled planar cell polarity protein
AliasesCRIB1; SCRB1; SCRIB1; Vartul
GeneCards (Weizmann)SCRIB
Ensembl hg19 (Hinxton)ENSG00000180900 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180900 [Gene_View]  chr8:143790920-143815379 [Contig_View]  SCRIB [Vega]
ICGC DataPortalENSG00000180900
TCGA cBioPortalSCRIB
AceView (NCBI)SCRIB
Genatlas (Paris)SCRIB
WikiGenes23513
SOURCE (Princeton)SCRIB
Genetics Home Reference (NIH)SCRIB
Genomic and cartography
GoldenPath hg38 (UCSC)SCRIB  -     chr8:143790920-143815379 -  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCRIB  -     8q24.3   [Description]    (hg19-Feb_2009)
EnsemblSCRIB - 8q24.3 [CytoView hg19]  SCRIB - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBISCRIB [Mapview hg19]  SCRIB [Mapview hg38]
OMIM607733   
Gene and transcription
Genbank (Entrez)AF240677 AF271734 AF318352 AI829609 AY062238
RefSeq transcript (Entrez)NM_015356 NM_182706
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_030583 NT_187571
Consensus coding sequences : CCDS (NCBI)SCRIB
Cluster EST : UnigeneHs.436329 [ NCBI ]
CGAP (NCI)Hs.436329
Alternative Splicing GalleryENSG00000180900
Gene ExpressionSCRIB [ NCBI-GEO ]   SCRIB [ EBI - ARRAY_EXPRESS ]   SCRIB [ SEEK ]   SCRIB [ MEM ]
Gene Expression Viewer (FireBrowse)SCRIB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23513
GTEX Portal (Tissue expression)SCRIB
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14160   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14160  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14160
Splice isoforms : SwissVarQ14160
PhosPhoSitePlusQ14160
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    PDZ (PS50106)   
Domains : Interpro (EBI)L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    PDZ   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam13855    pfam00595   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  PDZ (SM00228)  
Conserved Domain (NCBI)SCRIB
DMDM Disease mutations23513
Blocks (Seattle)SCRIB
PDB (SRS)1UJU    1WHA    1X5Q    2W4F    4WYT    4WYU   
PDB (PDBSum)1UJU    1WHA    1X5Q    2W4F    4WYT    4WYU   
PDB (IMB)1UJU    1WHA    1X5Q    2W4F    4WYT    4WYU   
PDB (RSDB)1UJU    1WHA    1X5Q    2W4F    4WYT    4WYU   
Structural Biology KnowledgeBase1UJU    1WHA    1X5Q    2W4F    4WYT    4WYU   
SCOP (Structural Classification of Proteins)1UJU    1WHA    1X5Q    2W4F    4WYT    4WYU   
CATH (Classification of proteins structures)1UJU    1WHA    1X5Q    2W4F    4WYT    4WYU   
SuperfamilyQ14160
Human Protein AtlasENSG00000180900
Peptide AtlasQ14160
HPRD06984
IPIIPI00425560   IPI00425562   IPI00410666   IPI00395630   IPI00982057   IPI00982667   
Protein Interaction databases
DIP (DOE-UCLA)Q14160
IntAct (EBI)Q14160
FunCoupENSG00000180900
BioGRIDSCRIB
STRING (EMBL)SCRIB
ZODIACSCRIB
Ontologies - Pathways
QuickGOQ14160
Ontology : AmiGOneural tube closure  positive regulation of receptor recycling  guanylate kinase activity  protein binding  nucleoplasm  plasma membrane  plasma membrane  cell-cell junction  cell-cell adherens junction  chemical synaptic transmission  asymmetric protein localization  cell proliferation  ionotropic glutamate receptor complex  postsynaptic density  viral process  synaptic vesicle targeting  basolateral plasma membrane  single organismal cell-cell adhesion  cell migration  cochlear nucleus development  lamellipodium  cell junction  cell leading edge  Scrib-APC-beta-catenin complex  establishment of apical/basal cell polarity  ionotropic glutamate receptor binding  myelin sheath abaxonal region  wound healing  presynaptic membrane  positive regulation of apoptotic process  receptor clustering  astrocyte cell migration  cell-cell contact zone  establishment or maintenance of epithelial cell apical/basal polarity  postsynaptic membrane  cadherin binding  negative regulation of mitotic cell cycle  GMP metabolic process  GDP metabolic process  synaptic vesicle endocytosis  positive chemotaxis  auditory receptor cell stereocilium organization  apoptotic process involved in morphogenesis  mammary gland duct morphogenesis  extracellular exosome  protein localization to adherens junction  activation of GTPase activity  receptor localization to synapse  neurotransmitter receptor transport, endosome to postsynaptic membrane  neurotransmitter receptor transport postsynaptic membrane to endosome  
Oft/logy : EGO-EBIneural tube closure  positive regulation of receptor recycling  guanylate kinase activity  protein binding  nucleoplasm  plasma membrane  plasma membrane  cell-cell junction  cell-cell adherens junction  chemical synaptic transmission  asymmetric protein localization  cell proliferation  ionotropic glutamate receptor complex  postsynaptic density  viral process  synaptic vesicle targeting  basolateral plasma membrane  single organismal cell-cell adhesion  cell migration  cochlear nucleus development  lamellipodium  cell junction  cell leading edge  Scrib-APC-beta-catenin complex  establishment of apical/basal cell polarity  ionotropic glutamate receptor binding  myelin sheath abaxonal region  wound healing  presynaptic membrane  positive regulation of apoptotic process  receptor clustering  astrocyte cell migration  cell-cell contact zone  establishment or maintenance of epithelial cell apical/basal polarity  postsynaptic membrane  cadherin binding  negative regulation of mitotic cell cycle  GMP metabolic process  GDP metabolic process  synaptic vesicle endocytosis  positive chemotaxis  auditory receptor cell stereocilium organization  apoptotic process involved in morphogenesis  mammary gland duct morphogenesis  extracellular exosome  protein localization to adherens junction  activation of GTPase activity  receptor localization to synapse  neurotransmitter receptor transport, endosome to postsynaptic membrane  neurotransmitter receptor transport postsynaptic membrane to endosome  
Pathways : KEGGHippo signaling pathway    Viral carcinogenesis   
NDEx NetworkSCRIB
Atlas of Cancer Signalling NetworkSCRIB
Wikipedia pathwaysSCRIB
Orthology - Evolution
OrthoDB23513
GeneTree (enSembl)ENSG00000180900
Phylogenetic Trees/Animal Genes : TreeFamSCRIB
HOVERGENQ14160
HOGENOMQ14160
Homologs : HomoloGeneSCRIB
Homology/Alignments : Family Browser (UCSC)SCRIB
Gene fusions - Rearrangements
Fusion : MitelmanSCRIB/NRBP2 [8q24.3/8q24.3]  
Fusion: TCGASCRIB 8q24.3 NRBP2 8q24.3 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCRIB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SCRIB
dbVarSCRIB
ClinVarSCRIB
1000_GenomesSCRIB 
Exome Variant ServerSCRIB
ExAC (Exome Aggregation Consortium)SCRIB (select the gene name)
Genetic variants : HAPMAP23513
Genomic Variants (DGV)SCRIB [DGVbeta]
DECIPHERSCRIB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCRIB 
Mutations
ICGC Data PortalSCRIB 
TCGA Data PortalSCRIB 
Broad Tumor PortalSCRIB
OASIS PortalSCRIB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCRIB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSCRIB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch SCRIB
DgiDB (Drug Gene Interaction Database)SCRIB
DoCM (Curated mutations)SCRIB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SCRIB (select a term)
intoGenSCRIB
Cancer3DSCRIB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607733   
Orphanet
MedgenSCRIB
Genetic Testing Registry SCRIB
NextProtQ14160 [Medical]
TSGene23513
GENETestsSCRIB
Target ValidationSCRIB
Huge Navigator SCRIB [HugePedia]
snp3D : Map Gene to Disease23513
BioCentury BCIQSCRIB
ClinGenSCRIB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23513
Chemical/Pharm GKB GenePA134936275
Clinical trialSCRIB
Miscellaneous
canSAR (ICR)SCRIB (select the gene name)
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSCRIB
EVEXSCRIB
GoPubMedSCRIB
iHOPSCRIB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:06:44 CEST 2017
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