Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SCT (secretin)

Identity

Alias (NCBI)-
HGNC (Hugo) SCT
HGNC Alias nameprepro-secretin
LocusID (NCBI) 6343
Atlas_Id 51543
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 626309 and ends at 627181 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RNH1 (11p15.5) / SCT (11p15.5)RNH1 11p15.5 / SCT 11p15.5

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  RNH1/SCT (11p15)

External links

Nomenclature
HGNC (Hugo)SCT   10607
Cards
Entrez_Gene (NCBI)SCT    secretin
Aliases
GeneCards (Weizmann)SCT
Ensembl hg19 (Hinxton)ENSG00000070031 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070031 [Gene_View]  ENSG00000070031 [Sequence]  chr11:626309-627181 [Contig_View]  SCT [Vega]
ICGC DataPortalENSG00000070031
TCGA cBioPortalSCT
AceView (NCBI)SCT
Genatlas (Paris)SCT
SOURCE (Princeton)SCT
Genetics Home Reference (NIH)SCT
Genomic and cartography
GoldenPath hg38 (UCSC)SCT  -     chr11:626309-627181 -  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCT  -     11p15.5   [Description]    (hg19-Feb_2009)
GoldenPathSCT - 11p15.5 [CytoView hg19]  SCT - 11p15.5 [CytoView hg38]
ImmunoBaseENSG00000070031
genome Data Viewer NCBISCT [Mapview hg19]  
OMIM182099   
Gene and transcription
Genbank (Entrez)HY019819 HY243621
RefSeq transcript (Entrez)NM_021920
RefSeq genomic (Entrez)NC_000011 NT_187586
Consensus coding sequences : CCDS (NCBI)SCT
Alternative Splicing GalleryENSG00000070031
Gene ExpressionSCT [ NCBI-GEO ]   SCT [ EBI - ARRAY_EXPRESS ]   SCT [ SEEK ]   SCT [ MEM ]
Gene Expression Viewer (FireBrowse)SCT [ Firebrowse - Broad ]
GenevisibleExpression of SCT in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6343
GTEX Portal (Tissue expression)SCT
Human Protein AtlasENSG00000070031-SCT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09683   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09683  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09683
Splice isoforms : SwissVarP09683
PhosPhoSitePlusP09683
Domaine pattern : Prosite (Expaxy)GLUCAGON (PS00260)   
Domains : Interpro (EBI)Glucagon_GIP_secretin_VIP    Prosecretin   
Domain families : Pfam (Sanger)Hormone_2 (PF00123)   
Domain families : Pfam (NCBI)pfam00123   
Domain families : Smart (EMBL)GLUCA (SM00070)  
Conserved Domain (NCBI)SCT
Blocks (Seattle)SCT
SuperfamilyP09683
Human Protein Atlas [tissue]ENSG00000070031-SCT [tissue]
Peptide AtlasP09683
HPRD08354
IPIIPI00016001   
Protein Interaction databases
DIP (DOE-UCLA)P09683
IntAct (EBI)P09683
BioGRIDSCT
STRING (EMBL)SCT
ZODIACSCT
Ontologies - Pathways
QuickGOP09683
Ontology : AmiGOG protein-coupled receptor binding  diet induced thermogenesis  signaling receptor binding  hormone activity  hormone activity  cellular_component  extracellular region  extracellular space  extracellular space  G protein-coupled receptor signaling pathway  brain development  cellular water homeostasis  hippocampus development  pancreatic juice secretion  response to nutrient levels  regulation of appetite  positive regulation of cAMP-mediated signaling  digestive hormone activity  protein N-terminus binding  regulation of synaptic plasticity  embryonic digestive tract development  positive regulation of lipid catabolic process  positive regulation of pancreatic juice secretion  positive regulation of somatostatin secretion  negative regulation of gastrin-induced gastric acid secretion  
Ontology : EGO-EBIG protein-coupled receptor binding  diet induced thermogenesis  signaling receptor binding  hormone activity  hormone activity  cellular_component  extracellular region  extracellular space  extracellular space  G protein-coupled receptor signaling pathway  brain development  cellular water homeostasis  hippocampus development  pancreatic juice secretion  response to nutrient levels  regulation of appetite  positive regulation of cAMP-mediated signaling  digestive hormone activity  protein N-terminus binding  regulation of synaptic plasticity  embryonic digestive tract development  positive regulation of lipid catabolic process  positive regulation of pancreatic juice secretion  positive regulation of somatostatin secretion  negative regulation of gastrin-induced gastric acid secretion  
NDEx NetworkSCT
Atlas of Cancer Signalling NetworkSCT
Wikipedia pathwaysSCT
Orthology - Evolution
OrthoDB6343
GeneTree (enSembl)ENSG00000070031
Phylogenetic Trees/Animal Genes : TreeFamSCT
HOGENOMP09683
Homologs : HomoloGeneSCT
Homology/Alignments : Family Browser (UCSC)SCT
Gene fusions - Rearrangements
Fusion : MitelmanRNH1/SCT [11p15.5/11p15.5]  
Fusion PortalRNH1 11p15.5 SCT 11p15.5 BRCA
Fusion : QuiverSCT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCT [hg38]
dbVarSCT
ClinVarSCT
MonarchSCT
1000_GenomesSCT 
Exome Variant ServerSCT
GNOMAD BrowserENSG00000070031
Varsome BrowserSCT
Genomic Variants (DGV)SCT [DGVbeta]
DECIPHERSCT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCT 
Mutations
ICGC Data PortalSCT 
TCGA Data PortalSCT 
Broad Tumor PortalSCT
OASIS PortalSCT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCT  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSCT
Mutations and Diseases : HGMDSCT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SCT
DgiDB (Drug Gene Interaction Database)SCT
DoCM (Curated mutations)SCT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SCT (select a term)
intoGenSCT
Cancer3DSCT(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182099   
Orphanet
DisGeNETSCT
MedgenSCT
Genetic Testing Registry SCT
NextProtP09683 [Medical]
GENETestsSCT
Target ValidationSCT
Huge Navigator SCT [HugePedia]
ClinGenSCT
Clinical trials, drugs, therapy
MyCancerGenomeSCT
Protein Interactions : CTD
Pharm GKB GenePA35017
PharosP09683
Clinical trialSCT
Miscellaneous
canSAR (ICR)SCT (select the gene name)
HarmonizomeSCT
DataMed IndexSCT
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSCT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:36:26 CET 2021
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