SCT (secretin)

2010-07-01  

Identity

HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 6343
MIM: 182099
HGNC: 10607
Ensembl: ENSG00000070031

Variants:

dbSNP: 6343
ClinVar: 6343
TCGA: ENSG00000070031
COSMIC: SCT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070031ENST00000176195P09683

Expression (GTEx)

0
1
2
3
4
5
6
7

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
230640142012A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.77
203989082010Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.32
199047462010Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor.27
232335322013CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin.26
229643052012Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping.14
151180682004Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element.13
192396252009Secretin-induced gastric relaxation is mediated by vasoactive intestinal polypeptide and prostaglandin pathways.6
218510582011Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist.5
156101582004Transient expression of secretin in serotoninergic neurons of mouse brain during development.4
193721042009Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP).4

Citation

Dessen P

SCT (secretin)

Atlas Genet Cytogenet Oncol Haematol. 2010-07-01

Online version: http://atlasgeneticsoncology.org/gene/51543/sct