SCTR (secretin receptor)

2003-06-01  

Identity

HGNC
LOCATION
2q14.2
LOCUSID
ALIAS
SR

Other Information

Locus ID:

NCBI: 6344
MIM: 182098
HGNC: 10608
Ensembl: ENSG00000080293

Variants:

dbSNP: 6344
ClinVar: 6344
TCGA: ENSG00000080293
COSMIC: SCTR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000080293ENST00000019103P47872
ENSG00000080293ENST00000627145A0A0D9SFY2
ENSG00000080293ENST00000630739A0A0D9SFV7

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
271152852016The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor-β1 biliary secretion in mice.30
199047462010Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor.27
184017612008Pattern of intra-family hetero-oligomerization involving the G-protein-coupled secretin receptor.24
186807172008Dimerization in the absence of higher-order oligomerization of the G protein-coupled secretin receptor.24
198866712009Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor.22
168198202006Secretin receptor oligomers form intracellularly during maturation through receptor core domains.16
169353832006Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma.14
229643052012Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping.14
252410332014Gene expression accurately distinguishes liver metastases of small bowel and pancreas neuroendocrine tumors.13
146454992004CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene.12

Citation

Dessen P

SCTR (secretin receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42220/sctr