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SCUBE1 (signal peptide, CUB domain and EGF like domain containing 1)

Identity

Alias_namessignal peptide
Other alias-
HGNC (Hugo) SCUBE1
LocusID (NCBI) 80274
Atlas_Id 53325
Location 22q13.2  [Link to chromosome band 22q13]
Location_base_pair Starts at 43203223 and ends at 43343388 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CERK (22q13.31) / SCUBE1 (22q13.2)MIRLET7BHG (22q13.31) / SCUBE1 (22q13.2)CERK 22q13.31 / SCUBE1 22q13.2
MIRLET7BHG 22q13.31 / SCUBE1 22q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SCUBE1   13441
Cards
Entrez_Gene (NCBI)SCUBE1  80274  signal peptide, CUB domain and EGF like domain containing 1
Aliases
GeneCards (Weizmann)SCUBE1
Ensembl hg19 (Hinxton)ENSG00000159307 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159307 [Gene_View]  chr22:43203223-43343388 [Contig_View]  SCUBE1 [Vega]
ICGC DataPortalENSG00000159307
TCGA cBioPortalSCUBE1
AceView (NCBI)SCUBE1
Genatlas (Paris)SCUBE1
WikiGenes80274
SOURCE (Princeton)SCUBE1
Genetics Home Reference (NIH)SCUBE1
Genomic and cartography
GoldenPath hg38 (UCSC)SCUBE1  -     chr22:43203223-43343388 -  22q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCUBE1  -     22q13.2   [Description]    (hg19-Feb_2009)
EnsemblSCUBE1 - 22q13.2 [CytoView hg19]  SCUBE1 - 22q13.2 [CytoView hg38]
Mapping of homologs : NCBISCUBE1 [Mapview hg19]  SCUBE1 [Mapview hg38]
OMIM611746   
Gene and transcription
Genbank (Entrez)AF525689 AK127719 BC047916 BC127263 BC156731
RefSeq transcript (Entrez)NM_173050
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SCUBE1
Cluster EST : UnigeneHs.133995 [ NCBI ]
CGAP (NCI)Hs.133995
Alternative Splicing GalleryENSG00000159307
Gene ExpressionSCUBE1 [ NCBI-GEO ]   SCUBE1 [ EBI - ARRAY_EXPRESS ]   SCUBE1 [ SEEK ]   SCUBE1 [ MEM ]
Gene Expression Viewer (FireBrowse)SCUBE1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80274
GTEX Portal (Tissue expression)SCUBE1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWY4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWY4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWY4
Splice isoforms : SwissVarQ8IWY4
PhosPhoSitePlusQ8IWY4
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    CUB (PS01180)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)   
Domains : Interpro (EBI)cEGF    CUB_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    EGF_dom    Growth_fac_rcpt_    Tyr-kin_ephrin_A/B_rcpt-like   
Domain families : Pfam (Sanger)cEGF (PF12662)    CUB (PF00431)    EGF_3 (PF12947)    EGF_CA (PF07645)    Ephrin_rec_like (PF07699)   
Domain families : Pfam (NCBI)pfam12662    pfam00431    pfam12947    pfam07645    pfam07699   
Domain families : Smart (EMBL)CUB (SM00042)  EGF (SM00181)  EGF_CA (SM00179)  Ephrin_rec_like (SM01411)  
Conserved Domain (NCBI)SCUBE1
DMDM Disease mutations80274
Blocks (Seattle)SCUBE1
SuperfamilyQ8IWY4
Human Protein AtlasENSG00000159307
Peptide AtlasQ8IWY4
HPRD18029
IPIIPI00217435   IPI00747808   IPI00880051   IPI00395866   IPI00877756   
Protein Interaction databases
DIP (DOE-UCLA)Q8IWY4
IntAct (EBI)Q8IWY4
FunCoupENSG00000159307
BioGRIDSCUBE1
STRING (EMBL)SCUBE1
ZODIACSCUBE1
Ontologies - Pathways
QuickGOQ8IWY4
Ontology : AmiGOcalcium ion binding  extracellular space  inflammatory response  signal transduction  adult heart development  blood coagulation  post-embryonic development  external side of plasma membrane  cell surface  extrinsic component of plasma membrane  cell differentiation  identical protein binding  endothelial cell differentiation  positive regulation of smoothened signaling pathway  protein heterodimerization activity  protein homooligomerization  
Ontology : EGO-EBIcalcium ion binding  extracellular space  inflammatory response  signal transduction  adult heart development  blood coagulation  post-embryonic development  external side of plasma membrane  cell surface  extrinsic component of plasma membrane  cell differentiation  identical protein binding  endothelial cell differentiation  positive regulation of smoothened signaling pathway  protein heterodimerization activity  protein homooligomerization  
NDEx NetworkSCUBE1
Atlas of Cancer Signalling NetworkSCUBE1
Wikipedia pathwaysSCUBE1
Orthology - Evolution
OrthoDB80274
GeneTree (enSembl)ENSG00000159307
Phylogenetic Trees/Animal Genes : TreeFamSCUBE1
HOVERGENQ8IWY4
HOGENOMQ8IWY4
Homologs : HomoloGeneSCUBE1
Homology/Alignments : Family Browser (UCSC)SCUBE1
Gene fusions - Rearrangements
Fusion : MitelmanCERK/SCUBE1 [22q13.31/22q13.2]  [t(22;22)(q13;q13)]  
Fusion : MitelmanMIRLET7BHG/SCUBE1 [22q13.31/22q13.2]  [t(22;22)(q13;q13)]  
Fusion: TCGACERK 22q13.31 SCUBE1 22q13.2 PRAD
Fusion: TCGAMIRLET7BHG 22q13.31 SCUBE1 22q13.2 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCUBE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SCUBE1
dbVarSCUBE1
ClinVarSCUBE1
1000_GenomesSCUBE1 
Exome Variant ServerSCUBE1
ExAC (Exome Aggregation Consortium)SCUBE1 (select the gene name)
Genetic variants : HAPMAP80274
Genomic Variants (DGV)SCUBE1 [DGVbeta]
DECIPHERSCUBE1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCUBE1 
Mutations
ICGC Data PortalSCUBE1 
TCGA Data PortalSCUBE1 
Broad Tumor PortalSCUBE1
OASIS PortalSCUBE1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCUBE1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSCUBE1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SCUBE1
DgiDB (Drug Gene Interaction Database)SCUBE1
DoCM (Curated mutations)SCUBE1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SCUBE1 (select a term)
intoGenSCUBE1
Cancer3DSCUBE1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611746   
Orphanet
MedgenSCUBE1
Genetic Testing Registry SCUBE1
NextProtQ8IWY4 [Medical]
TSGene80274
GENETestsSCUBE1
Target ValidationSCUBE1
Huge Navigator SCUBE1 [HugePedia]
snp3D : Map Gene to Disease80274
BioCentury BCIQSCUBE1
ClinGenSCUBE1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80274
Chemical/Pharm GKB GenePA35019
Clinical trialSCUBE1
Miscellaneous
canSAR (ICR)SCUBE1 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSCUBE1
EVEXSCUBE1
GoPubMedSCUBE1
iHOPSCUBE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:30:13 CEST 2017

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