SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2)

2009-06-01  

Identity

HGNC
SCUBE2
LOCATION
11p15.4
LOCUSID
57758
ALIAS
CEGB1,CEGF1,CEGP1,scube/You
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57758
MIM: 611747
HGNC: 30425
Ensembl: ENSG00000175356

Variants:

dbSNP: 57758
ClinVar: 57758
TCGA: ENSG00000175356
COSMIC: SCUBE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175356ENST00000309263Q9NQ36
ENSG00000175356ENST00000450649Q9NQ36
ENSG00000175356ENST00000519202H0YD28
ENSG00000175356ENST00000519788H0YEB3
ENSG00000175356ENST00000520467Q9NQ36
ENSG00000175356ENST00000528651H0YEI5
ENSG00000175356ENST00000531429H0YDN3
ENSG00000175356ENST00000649792A0A3B3ISZ7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog ligand biogenesisREACTOMER-HSA-5358346
Release of Hh-Np from the secreting cellREACTOMER-HSA-5362798

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
122709312002Identification of a novel family of cell-surface proteins expressed in human vascular endothelium.35
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
194806262009Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans.17
242135322014Tumor suppressor SCUBE2 inhibits breast-cancer cell migration and invasion through the reversal of epithelial-mesenchymal transition.15
193692672009SCUBE2 suppresses breast tumor cell proliferation and confers a favorable prognosis in invasive breast cancer.14
245221952014Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells.13
196251762009PTEN identified as important risk factor of chronic obstructive pulmonary disease.12
271992532016Bridging the gap: heparan sulfate and Scube2 assemble Sonic hedgehog release complexes at the surface of producing cells.12

Citation

Dessen P

SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50982/scube2