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SCUBE3 (signal peptide, CUB domain and EGF like domain containing 3)

Identity

Alias_namesCEGF3
CUB domain and EGF-like repeat containing 3
signal peptide, CUB domain, EGF-like 3
Alias_symbol (synonym)FLJ34743
Other alias
HGNC (Hugo) SCUBE3
LocusID (NCBI) 222663
Atlas_Id 52467
Location 6p21.31  [Link to chromosome band 6p21]
Location_base_pair Starts at 35214062 and ends at 35253079 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MUC16 (19p13.2) / SCUBE3 (6p21.31)SCUBE3 (6p21.31) / SCUBE3 (6p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SCUBE3   13655
Cards
Entrez_Gene (NCBI)SCUBE3  222663  signal peptide, CUB domain and EGF like domain containing 3
AliasesCEGF3
GeneCards (Weizmann)SCUBE3
Ensembl hg19 (Hinxton)ENSG00000146197 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146197 [Gene_View]  ENSG00000146197 [Sequence]  chr6:35214062-35253079 [Contig_View]  SCUBE3 [Vega]
ICGC DataPortalENSG00000146197
TCGA cBioPortalSCUBE3
AceView (NCBI)SCUBE3
Genatlas (Paris)SCUBE3
WikiGenes222663
SOURCE (Princeton)SCUBE3
Genetics Home Reference (NIH)SCUBE3
Genomic and cartography
GoldenPath hg38 (UCSC)SCUBE3  -     chr6:35214062-35253079 +  6p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCUBE3  -     6p21.31   [Description]    (hg19-Feb_2009)
EnsemblSCUBE3 - 6p21.31 [CytoView hg19]  SCUBE3 - 6p21.31 [CytoView hg38]
Mapping of homologs : NCBISCUBE3 [Mapview hg19]  SCUBE3 [Mapview hg38]
OMIM614708   
Gene and transcription
Genbank (Entrez)AF452494 AK092010 AK092062 AK123742 AK291218
RefSeq transcript (Entrez)NM_001303136 NM_152753
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SCUBE3
Cluster EST : UnigeneHs.12923 [ NCBI ]
CGAP (NCI)Hs.12923
Alternative Splicing GalleryENSG00000146197
Gene ExpressionSCUBE3 [ NCBI-GEO ]   SCUBE3 [ EBI - ARRAY_EXPRESS ]   SCUBE3 [ SEEK ]   SCUBE3 [ MEM ]
Gene Expression Viewer (FireBrowse)SCUBE3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)222663
GTEX Portal (Tissue expression)SCUBE3
Human Protein AtlasENSG00000146197-SCUBE3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IX30   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IX30  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IX30
Splice isoforms : SwissVarQ8IX30
PhosPhoSitePlusQ8IX30
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    CUB (PS01180)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)   
Domains : Interpro (EBI)cEGF    CUB_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    EGF_dom    Growth_fac_rcpt_cys_sf    Sperma_CUB_dom_sf    Tyr-kin_ephrin_A/B_rcpt-like   
Domain families : Pfam (Sanger)cEGF (PF12662)    CUB (PF00431)    EGF_3 (PF12947)    EGF_CA (PF07645)    Ephrin_rec_like (PF07699)   
Domain families : Pfam (NCBI)pfam12662    pfam00431    pfam12947    pfam07645    pfam07699   
Domain families : Smart (EMBL)CUB (SM00042)  EGF (SM00181)  EGF_CA (SM00179)  Ephrin_rec_like (SM01411)  
Conserved Domain (NCBI)SCUBE3
DMDM Disease mutations222663
Blocks (Seattle)SCUBE3
SuperfamilyQ8IX30
Human Protein Atlas [tissue]ENSG00000146197-SCUBE3 [tissue]
Peptide AtlasQ8IX30
HPRD18031
IPIIPI00329580   IPI00787846   
Protein Interaction databases
DIP (DOE-UCLA)Q8IX30
IntAct (EBI)Q8IX30
FunCoupENSG00000146197
BioGRIDSCUBE3
STRING (EMBL)SCUBE3
ZODIACSCUBE3
Ontologies - Pathways
QuickGOQ8IX30
Ontology : AmiGOcalcium ion binding  protein binding  extracellular space  plasma membrane  plasma membrane  cell surface  cell surface  extracellular matrix disassembly  positive regulation of smoothened signaling pathway  protein homooligomerization  protein heterooligomerization  
Ontology : EGO-EBIcalcium ion binding  protein binding  extracellular space  plasma membrane  plasma membrane  cell surface  cell surface  extracellular matrix disassembly  positive regulation of smoothened signaling pathway  protein homooligomerization  protein heterooligomerization  
NDEx NetworkSCUBE3
Atlas of Cancer Signalling NetworkSCUBE3
Wikipedia pathwaysSCUBE3
Orthology - Evolution
OrthoDB222663
GeneTree (enSembl)ENSG00000146197
Phylogenetic Trees/Animal Genes : TreeFamSCUBE3
HOVERGENQ8IX30
HOGENOMQ8IX30
Homologs : HomoloGeneSCUBE3
Homology/Alignments : Family Browser (UCSC)SCUBE3
Gene fusions - Rearrangements
Fusion : QuiverSCUBE3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCUBE3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SCUBE3
dbVarSCUBE3
ClinVarSCUBE3
1000_GenomesSCUBE3 
Exome Variant ServerSCUBE3
ExAC (Exome Aggregation Consortium)ENSG00000146197
GNOMAD BrowserENSG00000146197
Varsome BrowserSCUBE3
Genetic variants : HAPMAP222663
Genomic Variants (DGV)SCUBE3 [DGVbeta]
DECIPHERSCUBE3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCUBE3 
Mutations
ICGC Data PortalSCUBE3 
TCGA Data PortalSCUBE3 
Broad Tumor PortalSCUBE3
OASIS PortalSCUBE3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCUBE3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSCUBE3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SCUBE3
DgiDB (Drug Gene Interaction Database)SCUBE3
DoCM (Curated mutations)SCUBE3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SCUBE3 (select a term)
intoGenSCUBE3
Cancer3DSCUBE3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614708   
Orphanet
DisGeNETSCUBE3
MedgenSCUBE3
Genetic Testing Registry SCUBE3
NextProtQ8IX30 [Medical]
TSGene222663
GENETestsSCUBE3
Target ValidationSCUBE3
Huge Navigator SCUBE3 [HugePedia]
snp3D : Map Gene to Disease222663
BioCentury BCIQSCUBE3
ClinGenSCUBE3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD222663
Chemical/Pharm GKB GenePA134977856
Clinical trialSCUBE3
Miscellaneous
canSAR (ICR)SCUBE3 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSCUBE3
EVEXSCUBE3
GoPubMedSCUBE3
iHOPSCUBE3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:37:45 CET 2018

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