SCUBE3 (signal peptide, CUB domain and EGF like domain containing 3)

2011-10-01  

Identity

HGNC
SCUBE3
LOCATION
6p21.31
LOCUSID
222663
ALIAS
CEGF3,SSFSC2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 222663
MIM: 614708
HGNC: 13655
Ensembl: ENSG00000146197

Variants:

dbSNP: 222663
ClinVar: 222663
TCGA: ENSG00000146197
COSMIC: SCUBE3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146197ENST00000274938Q8IX30

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
152349722004A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones.22
205466122010The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.19
214419522011SCUBE3 is an endogenous TGF-β receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer.16
234204402013SCUBE3 regulation of early lung cancer angiogenesis and metastatic progression.9
272593222015The Expression of HSPD1, SCUBE3, CXCL14 and Its Relations with the Prognosis in Osteosarcoma.6
243903642013SCUBE3 overexpression predicts poor prognosis in non-small cell lung cancer.5
240845932013Scube regulates synovial angiogenesis-related signaling.3
282381852017Can signal peptide-CUB-EGF domain-containing protein (SCUBE) levels be a marker of angiogenesis in patients with psoriasis?0

Citation

Dessen P

SCUBE3 (signal peptide, CUB domain and EGF like domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52467/scube3