SCX (scleraxis bHLH transcription factor)

2014-09-01  

Identity

HGNC
SCX
LOCATION
8q24.3
LOCUSID
642658
ALIAS
SCXA,SCXB,bHLHa48

Other Information

Locus ID:

NCBI: 642658
MIM: 609067
HGNC: 32322
Ensembl: ENSG00000260428

Variants:

dbSNP: 642658
ClinVar: 642658
TCGA: ENSG00000260428
COSMIC: SCX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000260428ENST00000567180Q7RTU7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
227963422012Synergistic roles of scleraxis and Smads in the regulation of collagen 1α2 gene expression.17
198281332010Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription.15
297509942018Regulation of cardiac fibroblast MMP2 gene expression by scleraxis.5
268510782016Pharmacological Regulation of In Situ Tissue Stem Cells Differentiation for Soft Tissue Calcification Treatment.3
171294312006[Expression of Scleraxis in human periodontal ligament cells and gingival fibroblasts].0
190876402008[Effect of high glucose on the expression of transcription factor Scleraxis in periodontal ligament cells in vitro].0
219881702012Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis.0
241574182013Tgfβ-Smad and MAPK signaling mediate scleraxis and proteoglycan expression in heart valves.0
299062252018Scleraxis regulates Twist1 and Snai1 expression in the epithelial-to-mesenchymal transition.0

Citation

Dessen P

SCX (scleraxis bHLH transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54888/scx