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SCYL1 (SCY1 like pseudokinase 1)

Identity

Alias (NCBI)GKLP
HT019
NKTL
NTKL
P105
SCAR21
TAPK
TEIF
TRAP
HGNC (Hugo) SCYL1
HGNC Alias symbHT019
P105
GKLP
NKTL
TAPK
TRAP
TEIF
MGC78454
HGNC Alias nameteratoma-associated tyrosine kinase
 telomerase transcriptional elements-interacting factor
 telomerase regulation-associated protein
HGNC Previous nameNTKL
HGNC Previous nameN-terminal kinase-like
 SCY1-like 1 (S. cerevisiae)
 SCY1-like, kinase-like 1
LocusID (NCBI) 57410
Atlas_Id 43486
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 65525083 and ends at 65538704 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC30 (1p34.2) / SCYL1 (11q13.1)SCYL1 (11q13.1) / COL1A1 (17q21.33)SCYL1 (11q13.1) / FRMD8 (11q13.1)
SCYL1 (11q13.1) / RPS18 (6p21.32)SCYL1 (11q13.1) / TRPM8 (2q37.1)SCYL1 11q13.1 / FRMD8 11q13.1
SCYL1 11q13.1 / TRPM8 2q37.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SCYL1   14372
Cards
Entrez_Gene (NCBI)SCYL1    SCY1 like pseudokinase 1
AliasesGKLP; HT019; NKTL; NTKL; 
P105; SCAR21; TAPK; TEIF; TRAP
GeneCards (Weizmann)SCYL1
Ensembl hg19 (Hinxton)ENSG00000142186 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142186 [Gene_View]  ENSG00000142186 [Sequence]  chr11:65525083-65538704 [Contig_View]  SCYL1 [Vega]
ICGC DataPortalENSG00000142186
TCGA cBioPortalSCYL1
AceView (NCBI)SCYL1
Genatlas (Paris)SCYL1
SOURCE (Princeton)SCYL1
Genetics Home Reference (NIH)SCYL1
Genomic and cartography
GoldenPath hg38 (UCSC)SCYL1  -     chr11:65525083-65538704 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCYL1  -     11q13.1   [Description]    (hg19-Feb_2009)
GoldenPathSCYL1 - 11q13.1 [CytoView hg19]  SCYL1 - 11q13.1 [CytoView hg38]
ImmunoBaseENSG00000142186
Genome Data Viewer NCBISCYL1 [Mapview hg19]  
OMIM607982   616719   
Gene and transcription
Genbank (Entrez)AB047077 AB051427 AB051428 AF225424 AF297709
RefSeq transcript (Entrez)NM_001048218 NM_020680
Consensus coding sequences : CCDS (NCBI)SCYL1
Gene ExpressionSCYL1 [ NCBI-GEO ]   SCYL1 [ EBI - ARRAY_EXPRESS ]   SCYL1 [ SEEK ]   SCYL1 [ MEM ]
Gene Expression Viewer (FireBrowse)SCYL1 [ Firebrowse - Broad ]
GenevisibleExpression of SCYL1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57410
GTEX Portal (Tissue expression)SCYL1
Human Protein AtlasENSG00000142186-SCYL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96KG9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96KG9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96KG9
PhosPhoSitePlusQ96KG9
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Kinase-like_dom_sf    Prot_kinase_dom   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Conserved Domain (NCBI)SCYL1
SuperfamilyQ96KG9
AlphaFold pdb e-kbQ96KG9   
Human Protein Atlas [tissue]ENSG00000142186-SCYL1 [tissue]
HPRD06414
Protein Interaction databases
DIP (DOE-UCLA)Q96KG9
IntAct (EBI)Q96KG9
BioGRIDSCYL1
STRING (EMBL)SCYL1
ZODIACSCYL1
Ontologies - Pathways
QuickGOQ96KG9
Ontology : AmiGODNA binding  protein tyrosine kinase activity  ATP binding  nucleus  cytoplasm  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  cis-Golgi network  microtubule organizing center  cytosol  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  inflammatory response  membrane  peptidyl-tyrosine phosphorylation  spinal cord motor neuron differentiation  COPI vesicle coat  cellular protein localization  cadherin binding  neuron development  
Ontology : EGO-EBIDNA binding  protein tyrosine kinase activity  ATP binding  nucleus  cytoplasm  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  cis-Golgi network  microtubule organizing center  cytosol  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  inflammatory response  membrane  peptidyl-tyrosine phosphorylation  spinal cord motor neuron differentiation  COPI vesicle coat  cellular protein localization  cadherin binding  neuron development  
NDEx NetworkSCYL1
Atlas of Cancer Signalling NetworkSCYL1
Wikipedia pathwaysSCYL1
Orthology - Evolution
OrthoDB57410
GeneTree (enSembl)ENSG00000142186
Phylogenetic Trees/Animal Genes : TreeFamSCYL1
Homologs : HomoloGeneSCYL1
Homology/Alignments : Family Browser (UCSC)SCYL1
Gene fusions - Rearrangements
Fusion : MitelmanSCYL1/FRMD8 [11q13.1/11q13.1]  
Fusion : MitelmanSCYL1/TRPM8 [11q13.1/2q37.1]  
Fusion : QuiverSCYL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCYL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SCYL1
dbVarSCYL1
ClinVarSCYL1
MonarchSCYL1
1000_GenomesSCYL1 
Exome Variant ServerSCYL1
GNOMAD BrowserENSG00000142186
Varsome BrowserSCYL1
ACMGSCYL1 variants
VarityQ96KG9
Genomic Variants (DGV)SCYL1 [DGVbeta]
DECIPHERSCYL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCYL1 
Mutations
ICGC Data PortalSCYL1 
TCGA Data PortalSCYL1 
Broad Tumor PortalSCYL1
OASIS PortalSCYL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCYL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSCYL1
Mutations and Diseases : HGMDSCYL1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSCYL1
DgiDB (Drug Gene Interaction Database)SCYL1
DoCM (Curated mutations)SCYL1
CIViC (Clinical Interpretations of Variants in Cancer)SCYL1
Cancer3DSCYL1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607982    616719   
Orphanet
DisGeNETSCYL1
MedgenSCYL1
Genetic Testing Registry SCYL1
NextProtQ96KG9 [Medical]
GENETestsSCYL1
Target ValidationSCYL1
Huge Navigator SCYL1 [HugePedia]
ClinGenSCYL1
Clinical trials, drugs, therapy
MyCancerGenomeSCYL1
Protein Interactions : CTDSCYL1
Pharm GKB GenePA31812
PharosQ96KG9
Clinical trialSCYL1
Miscellaneous
canSAR (ICR)SCYL1
HarmonizomeSCYL1
DataMed IndexSCYL1
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSCYL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:30:20 CEST 2021

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