Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SCYL2 (SCY1 like pseudokinase 2)

Identity

Alias_namesSCY1-like 2 (S. cerevisiae)
SCY1-like, kinase-like 2
Alias_symbol (synonym)KIAA1360
CVAK104
Other alias
HGNC (Hugo) SCYL2
LocusID (NCBI) 55681
Atlas_Id 43487
Location 12q23.1  [Link to chromosome band 12q23]
Location_base_pair Starts at 100267140 and ends at 100341724 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SCYL2 (12q23.1) / ANKS1B (12q23.1)SCYL2 (12q23.1) / FAM71C (12q23.1)SCYL2 (12q23.1) / PTPRG (3p14.2)
SCYL2 12q23.1 / ANKS1B 12q23.1SCYL2 12q23.1 / FAM71C 12q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SCYL2   19286
Cards
Entrez_Gene (NCBI)SCYL2  55681  SCY1 like pseudokinase 2
AliasesCVAK104
GeneCards (Weizmann)SCYL2
Ensembl hg19 (Hinxton)ENSG00000136021 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136021 [Gene_View]  chr12:100267140-100341724 [Contig_View]  SCYL2 [Vega]
ICGC DataPortalENSG00000136021
TCGA cBioPortalSCYL2
AceView (NCBI)SCYL2
Genatlas (Paris)SCYL2
WikiGenes55681
SOURCE (Princeton)SCYL2
Genetics Home Reference (NIH)SCYL2
Genomic and cartography
GoldenPath hg38 (UCSC)SCYL2  -     chr12:100267140-100341724 +  12q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCYL2  -     12q23.1   [Description]    (hg19-Feb_2009)
EnsemblSCYL2 - 12q23.1 [CytoView hg19]  SCYL2 - 12q23.1 [CytoView hg38]
Mapping of homologs : NCBISCYL2 [Mapview hg19]  SCYL2 [Mapview hg38]
OMIM616365   
Gene and transcription
Genbank (Entrez)AB037781 AK000936 AK001597 AK024274 AK026160
RefSeq transcript (Entrez)NM_001317784 NM_001330253 NM_001330254 NM_001330256 NM_017988
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SCYL2
Cluster EST : UnigeneHs.506481 [ NCBI ]
CGAP (NCI)Hs.506481
Alternative Splicing GalleryENSG00000136021
Gene ExpressionSCYL2 [ NCBI-GEO ]   SCYL2 [ EBI - ARRAY_EXPRESS ]   SCYL2 [ SEEK ]   SCYL2 [ MEM ]
Gene Expression Viewer (FireBrowse)SCYL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55681
GTEX Portal (Tissue expression)SCYL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P3W7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P3W7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P3W7
Splice isoforms : SwissVarQ6P3W7
PhosPhoSitePlusQ6P3W7
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Kinase-like_dom    Prot_kinase_dom   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)SCYL2
DMDM Disease mutations55681
Blocks (Seattle)SCYL2
SuperfamilyQ6P3W7
Human Protein AtlasENSG00000136021
Peptide AtlasQ6P3W7
HPRD07642
IPIIPI00396218   IPI00479300   IPI01020995   IPI01021763   IPI01021909   IPI01021389   
Protein Interaction databases
DIP (DOE-UCLA)Q6P3W7
IntAct (EBI)Q6P3W7
FunCoupENSG00000136021
BioGRIDSCYL2
STRING (EMBL)SCYL2
ZODIACSCYL2
Ontologies - Pathways
QuickGOQ6P3W7
Ontology : AmiGOpositive regulation of receptor internalization  protein kinase activity  receptor binding  protein binding  ATP binding  Golgi apparatus  protein phosphorylation  endosome to lysosome transport  endosome membrane  clathrin-coated vesicle  perinuclear region of cytoplasm  negative regulation of canonical Wnt signaling pathway  receptor internalization involved in canonical Wnt signaling pathway  positive regulation of clathrin-dependent endocytosis  
Ontology : EGO-EBIpositive regulation of receptor internalization  protein kinase activity  receptor binding  protein binding  ATP binding  Golgi apparatus  protein phosphorylation  endosome to lysosome transport  endosome membrane  clathrin-coated vesicle  perinuclear region of cytoplasm  negative regulation of canonical Wnt signaling pathway  receptor internalization involved in canonical Wnt signaling pathway  positive regulation of clathrin-dependent endocytosis  
NDEx NetworkSCYL2
Atlas of Cancer Signalling NetworkSCYL2
Wikipedia pathwaysSCYL2
Orthology - Evolution
OrthoDB55681
GeneTree (enSembl)ENSG00000136021
Phylogenetic Trees/Animal Genes : TreeFamSCYL2
HOVERGENQ6P3W7
HOGENOMQ6P3W7
Homologs : HomoloGeneSCYL2
Homology/Alignments : Family Browser (UCSC)SCYL2
Gene fusions - Rearrangements
Fusion : MitelmanSCYL2/ANKS1B [12q23.1/12q23.1]  
Fusion : MitelmanSCYL2/FAM71C [12q23.1/12q23.1]  [t(12;12)(q23;q23)]  
Fusion: TCGASCYL2 12q23.1 ANKS1B 12q23.1 SKCM
Fusion: TCGASCYL2 12q23.1 FAM71C 12q23.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCYL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SCYL2
dbVarSCYL2
ClinVarSCYL2
1000_GenomesSCYL2 
Exome Variant ServerSCYL2
ExAC (Exome Aggregation Consortium)SCYL2 (select the gene name)
Genetic variants : HAPMAP55681
Genomic Variants (DGV)SCYL2 [DGVbeta]
DECIPHERSCYL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCYL2 
Mutations
ICGC Data PortalSCYL2 
TCGA Data PortalSCYL2 
Broad Tumor PortalSCYL2
OASIS PortalSCYL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCYL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSCYL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SCYL2
DgiDB (Drug Gene Interaction Database)SCYL2
DoCM (Curated mutations)SCYL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SCYL2 (select a term)
intoGenSCYL2
Cancer3DSCYL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616365   
Orphanet
MedgenSCYL2
Genetic Testing Registry SCYL2
NextProtQ6P3W7 [Medical]
TSGene55681
GENETestsSCYL2
Target ValidationSCYL2
Huge Navigator SCYL2 [HugePedia]
snp3D : Map Gene to Disease55681
BioCentury BCIQSCYL2
ClinGenSCYL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55681
Chemical/Pharm GKB GenePA134887807
Clinical trialSCYL2
Miscellaneous
canSAR (ICR)SCYL2 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSCYL2
EVEXSCYL2
GoPubMedSCYL2
iHOPSCYL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 14:06:45 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.