SDF4 (stromal cell derived factor 4)

2003-12-01  

Identity

HGNC
SDF4
LOCATION
1p36.33
LOCUSID
51150
ALIAS
Cab45,SDF-4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51150
MIM: 614282
HGNC: 24188
Ensembl: ENSG00000078808

Variants:

dbSNP: 51150
ClinVar: 51150
TCGA: ENSG00000078808
COSMIC: SDF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078808ENST00000403997H0Y3T6
ENSG00000078808ENST00000465727G3V1E2
ENSG00000078808ENST00000660930Q9BRK5
ENSG00000078808ENST00000660930A0A024R0A9

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
232669542012Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network.25
248100552014Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP.21
174428892007A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
271382532016Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network.11
257722372016Cab45S promotes cell proliferation through SERCA2b inhibition and Ca2+ signaling.7
195135692009Transcript analyses of stromal cell derived factors (SDFs): SDF-2, SDF-4 and SDF-5 reveal a different pattern of expression and prognostic association in human breast cancer.6
197732792009Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.6
255098782013[The effects of simulated microgravity on the pattern of gene expression in human bone marrow mesenchymal stem cells under osteogenic differentiation].1

Citation

Dessen P

SDF4 (stromal cell derived factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/899/sdf4