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SDHA (succinate dehydrogenase complex flavoprotein subunit A)

Identity

Alias (NCBI)CMD1GG
FP
MC2DN1
PGL5
SDH1
SDH2
SDHF
HGNC (Hugo) SDHA
HGNC Alias symbFP
SDHF
HGNC Alias namesuccinate dehydrogenase [ubiquinone] flavoprotein subunit
 flavoprotein subunit of complex II
HGNC Previous nameSDH2
HGNC Previous namesuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)
 succinate dehydrogenase complex subunit A, flavoprotein (Fp)
LocusID (NCBI) 6389
Atlas_Id 51180
Location 5p15.33  [Link to chromosome band 5p15]
Location_base_pair Starts at 218320 and ends at 257082 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LPCAT1 (5p15.33) / SDHA (5p15.33)SDHA (5p15.33) / GTPBP10 (7q21.13)SDHA (5p15.33) / NBAS (2p24.3)
SDHA (5p15.33) / NCL (2q37.1)LPCAT1 5p15.33 / SDHA 5p15.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Hereditary paraganglioma (PGL)


External links

Nomenclature
HGNC (Hugo)SDHA   10680
LRG (Locus Reference Genomic)LRG_315
Cards
Entrez_Gene (NCBI)SDHA    succinate dehydrogenase complex flavoprotein subunit A
AliasesCMD1GG; FP; MC2DN1; PGL5; 
SDH1; SDH2; SDHF
GeneCards (Weizmann)SDHA
Ensembl hg19 (Hinxton)ENSG00000073578 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000073578 [Gene_View]  ENSG00000073578 [Sequence]  chr5:218320-257082 [Contig_View]  SDHA [Vega]
ICGC DataPortalENSG00000073578
TCGA cBioPortalSDHA
AceView (NCBI)SDHA
Genatlas (Paris)SDHA
SOURCE (Princeton)SDHA
Genetics Home Reference (NIH)SDHA
Genomic and cartography
GoldenPath hg38 (UCSC)SDHA  -     chr5:218320-257082 +  5p15.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SDHA  -     5p15.33   [Description]    (hg19-Feb_2009)
GoldenPathSDHA - 5p15.33 [CytoView hg19]  SDHA - 5p15.33 [CytoView hg38]
ImmunoBaseENSG00000073578
genome Data Viewer NCBISDHA [Mapview hg19]  
OMIM252011   600857   613642   614165   
Gene and transcription
Genbank (Entrez)AB208991 AK094879 AK131350 AK131478 AK225027
RefSeq transcript (Entrez)NM_001294332 NM_001330758 NM_004168
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SDHA
Alternative Splicing GalleryENSG00000073578
Gene ExpressionSDHA [ NCBI-GEO ]   SDHA [ EBI - ARRAY_EXPRESS ]   SDHA [ SEEK ]   SDHA [ MEM ]
Gene Expression Viewer (FireBrowse)SDHA [ Firebrowse - Broad ]
GenevisibleExpression of SDHA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6389
GTEX Portal (Tissue expression)SDHA
Human Protein AtlasENSG00000073578-SDHA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31040   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31040  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31040
Splice isoforms : SwissVarP31040
PhosPhoSitePlusP31040
Domaine pattern : Prosite (Expaxy)FRD_SDH_FAD_BINDING (PS00504)   
Domains : Interpro (EBI)FAD-binding_2    FAD/NAD-bd_sf    FRD_SDH_FAD_BS    Fum_R/Succ_DH_flav-like_C_sf    Fum_Rdtase/Succ_DH_flav-like_C    Succ_DH/fumarate_Rdtase_cat_sf    Succ_DH_flav_su_fwd    Succ_Dhase_FrdA_Gneg   
Domain families : Pfam (Sanger)FAD_binding_2 (PF00890)    Succ_DH_flav_C (PF02910)   
Domain families : Pfam (NCBI)pfam00890    pfam02910   
Conserved Domain (NCBI)SDHA
Blocks (Seattle)SDHA
PDB (RSDB)6VAX   
PDB Europe6VAX   
PDB (PDBSum)6VAX   
PDB (IMB)6VAX   
Structural Biology KnowledgeBase6VAX   
SCOP (Structural Classification of Proteins)6VAX   
CATH (Classification of proteins structures)6VAX   
SuperfamilyP31040
Human Protein Atlas [tissue]ENSG00000073578-SDHA [tissue]
Peptide AtlasP31040
HPRD02914
IPIIPI00902754   IPI00305166   IPI00956532   IPI00217143   IPI00965327   IPI00964764   IPI00965026   IPI00964725   IPI00964436   
Protein Interaction databases
DIP (DOE-UCLA)P31040
IntAct (EBI)P31040
BioGRIDSDHA
STRING (EMBL)SDHA
ZODIACSDHA
Ontologies - Pathways
QuickGOP31040
Ontology : AmiGOsuccinate dehydrogenase activity  protein binding  nucleolus  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)  mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)  mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)  tricarboxylic acid cycle  tricarboxylic acid cycle  succinate metabolic process  mitochondrial electron transport, succinate to ubiquinone  nervous system development  succinate dehydrogenase (ubiquinone) activity  succinate dehydrogenase (ubiquinone) activity  electron transfer activity  respiratory electron transport chain  flavin adenine dinucleotide binding  
Ontology : EGO-EBIsuccinate dehydrogenase activity  protein binding  nucleolus  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)  mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)  mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)  tricarboxylic acid cycle  tricarboxylic acid cycle  succinate metabolic process  mitochondrial electron transport, succinate to ubiquinone  nervous system development  succinate dehydrogenase (ubiquinone) activity  succinate dehydrogenase (ubiquinone) activity  electron transfer activity  respiratory electron transport chain  flavin adenine dinucleotide binding  
Pathways : BIOCARTAElectron Transport Reaction in Mitochondria [Genes]   
Pathways : KEGGCitrate cycle (TCA cycle)    Oxidative phosphorylation    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Huntington's disease   
NDEx NetworkSDHA
Atlas of Cancer Signalling NetworkSDHA
Wikipedia pathwaysSDHA
Orthology - Evolution
OrthoDB6389
GeneTree (enSembl)ENSG00000073578
Phylogenetic Trees/Animal Genes : TreeFamSDHA
HOGENOMP31040
Homologs : HomoloGeneSDHA
Homology/Alignments : Family Browser (UCSC)SDHA
Gene fusions - Rearrangements
Fusion : MitelmanLPCAT1/SDHA [5p15.33/5p15.33]  
Fusion PortalLPCAT1 5p15.33 SDHA 5p15.33 LUAD
Fusion : QuiverSDHA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSDHA [hg38]
dbVarSDHA
ClinVarSDHA
MonarchSDHA
1000_GenomesSDHA 
Exome Variant ServerSDHA
GNOMAD BrowserENSG00000073578
Varsome BrowserSDHA
Genomic Variants (DGV)SDHA [DGVbeta]
DECIPHERSDHA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSDHA 
Mutations
ICGC Data PortalSDHA 
TCGA Data PortalSDHA 
Broad Tumor PortalSDHA
OASIS PortalSDHA [ Somatic mutations - Copy number]
Cancer Gene: CensusSDHA 
Somatic Mutations in Cancer : COSMICSDHA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSDHA
Mutations and Diseases : HGMDSDHA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
LOVD (Leiden Open Variation Database)TCA Cycle Gene Mutation Database
BioMutasearch SDHA
DgiDB (Drug Gene Interaction Database)SDHA
DoCM (Curated mutations)SDHA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SDHA (select a term)
intoGenSDHA
Cancer3DSDHA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM252011    600857    613642    614165   
Orphanet635    19814    3377    8775    10584   
DisGeNETSDHA
MedgenSDHA
Genetic Testing Registry SDHA
NextProtP31040 [Medical]
GENETestsSDHA
Target ValidationSDHA
Huge Navigator SDHA [HugePedia]
ClinGenSDHA
Clinical trials, drugs, therapy
MyCancerGenomeSDHA
Protein Interactions : CTD
Pharm GKB GenePA35605
PharosP31040
Clinical trialSDHA
Miscellaneous
canSAR (ICR)SDHA (select the gene name)
HarmonizomeSDHA
DataMed IndexSDHA
Probes
Litterature
PubMed163 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSDHA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:44:48 CET 2021

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