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SDHA (succinate dehydrogenase complex flavoprotein subunit A)

Identity

Alias_namesSDH2
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
succinate dehydrogenase complex subunit A, flavoprotein (Fp)
Alias_symbol (synonym)FP
SDHF
Other aliasCMD1GG
PGL5
SDH1
HGNC (Hugo) SDHA
LocusID (NCBI) 6389
Atlas_Id 51180
Location 5p15.33  [Link to chromosome band 5p15]
Location_base_pair Starts at 218338 and ends at 257197 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LPCAT1 (5p15.33) / SDHA (5p15.33)SDHA (5p15.33) / GTPBP10 (7q21.13)SDHA (5p15.33) / NBAS (2p24.3)
SDHA (5p15.33) / NCL (2q37.1)LPCAT1 5p15.33 / SDHA 5p15.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Head and Neck: Paraganglioma: an overview


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Hereditary paraganglioma (PGL)


External links

Nomenclature
HGNC (Hugo)SDHA   10680
LRG (Locus Reference Genomic)LRG_315
Cards
Entrez_Gene (NCBI)SDHA  6389  succinate dehydrogenase complex flavoprotein subunit A
AliasesCMD1GG; FP; PGL5; SDH1; 
SDH2; SDHF
GeneCards (Weizmann)SDHA
Ensembl hg19 (Hinxton)ENSG00000073578 [Gene_View]  chr5:218338-257197 [Contig_View]  SDHA [Vega]
Ensembl hg38 (Hinxton)ENSG00000073578 [Gene_View]  chr5:218338-257197 [Contig_View]  SDHA [Vega]
ICGC DataPortalENSG00000073578
TCGA cBioPortalSDHA
AceView (NCBI)SDHA
Genatlas (Paris)SDHA
WikiGenes6389
SOURCE (Princeton)SDHA
Genetics Home Reference (NIH)SDHA
Genomic and cartography
GoldenPath hg19 (UCSC)SDHA  -     chr5:218338-257197 +  5p15.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SDHA  -     5p15.33   [Description]    (hg38-Dec_2013)
EnsemblSDHA - 5p15.33 [CytoView hg19]  SDHA - 5p15.33 [CytoView hg38]
Mapping of homologs : NCBISDHA [Mapview hg19]  SDHA [Mapview hg38]
OMIM252011   256000   600857   613642   614165   
Gene and transcription
Genbank (Entrez)AB208991 AK094879 AK131350 AK131478 AK225027
RefSeq transcript (Entrez)NM_001294332 NM_004168
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_012339 NT_006576 NW_004929321
Consensus coding sequences : CCDS (NCBI)SDHA
Cluster EST : UnigeneHs.440475 [ NCBI ]
CGAP (NCI)Hs.440475
Alternative Splicing GalleryENSG00000073578
Gene ExpressionSDHA [ NCBI-GEO ]   SDHA [ EBI - ARRAY_EXPRESS ]   SDHA [ SEEK ]   SDHA [ MEM ]
Gene Expression Viewer (FireBrowse)SDHA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6389
GTEX Portal (Tissue expression)SDHA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31040   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31040  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31040
Splice isoforms : SwissVarP31040
PhosPhoSitePlusP31040
Domaine pattern : Prosite (Expaxy)FRD_SDH_FAD_BINDING (PS00504)   
Domains : Interpro (EBI)FAD-binding_2    FAD/NAD-binding_dom    FRD_SDH_FAD_BS    Fum_Rdtase/Succ_DH_flav-like_C    SdhA/FrdA/AprA    Succ_DH/fumarate_Rdtase_cat    Succ_DH_flav_su_fwd    Succ_Dhase_FrdA_Gneg   
Domain families : Pfam (Sanger)FAD_binding_2 (PF00890)    Succ_DH_flav_C (PF02910)   
Domain families : Pfam (NCBI)pfam00890    pfam02910   
Conserved Domain (NCBI)SDHA
DMDM Disease mutations6389
Blocks (Seattle)SDHA
SuperfamilyP31040
Human Protein AtlasENSG00000073578
Peptide AtlasP31040
HPRD02914
IPIIPI00902754   IPI00305166   IPI00956532   IPI00217143   IPI00965327   IPI00964764   IPI00965026   IPI00964725   IPI00964436   
Protein Interaction databases
DIP (DOE-UCLA)P31040
IntAct (EBI)P31040
FunCoupENSG00000073578
BioGRIDSDHA
STRING (EMBL)SDHA
ZODIACSDHA
Ontologies - Pathways
QuickGOP31040
Ontology : AmiGOsuccinate dehydrogenase activity  protein binding  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)  mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)  tricarboxylic acid cycle  tricarboxylic acid cycle  succinate metabolic process  nervous system development  succinate dehydrogenase (ubiquinone) activity  respiratory electron transport chain  myelin sheath  flavin adenine dinucleotide binding  oxidation-reduction process  
Ontology : EGO-EBIsuccinate dehydrogenase activity  protein binding  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)  mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)  tricarboxylic acid cycle  tricarboxylic acid cycle  succinate metabolic process  nervous system development  succinate dehydrogenase (ubiquinone) activity  respiratory electron transport chain  myelin sheath  flavin adenine dinucleotide binding  oxidation-reduction process  
Pathways : BIOCARTAElectron Transport Reaction in Mitochondria [Genes]   
Pathways : KEGGCitrate cycle (TCA cycle)    Oxidative phosphorylation    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Huntington's disease   
NDEx NetworkSDHA
Atlas of Cancer Signalling NetworkSDHA
Wikipedia pathwaysSDHA
Orthology - Evolution
OrthoDB6389
GeneTree (enSembl)ENSG00000073578
Phylogenetic Trees/Animal Genes : TreeFamSDHA
HOVERGENP31040
HOGENOMP31040
Homologs : HomoloGeneSDHA
Homology/Alignments : Family Browser (UCSC)SDHA
Gene fusions - Rearrangements
Fusion : MitelmanLPCAT1/SDHA [5p15.33/5p15.33]  [t(5;5)(p15;p15)]  
Fusion: TCGALPCAT1 5p15.33 SDHA 5p15.33 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSDHA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SDHA
dbVarSDHA
ClinVarSDHA
1000_GenomesSDHA 
Exome Variant ServerSDHA
ExAC (Exome Aggregation Consortium)SDHA (select the gene name)
Genetic variants : HAPMAP6389
Genomic Variants (DGV)SDHA [DGVbeta]
DECIPHER (Syndromes)5:218338-257197  ENSG00000073578
CONAN: Copy Number AnalysisSDHA 
Mutations
ICGC Data PortalSDHA 
TCGA Data PortalSDHA 
Broad Tumor PortalSDHA
OASIS PortalSDHA [ Somatic mutations - Copy number]
Cancer Gene: CensusSDHA 
Somatic Mutations in Cancer : COSMICSDHA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSDHA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
LOVD (Leiden Open Variation Database)TCA Cycle Gene Mutation Database
BioMutasearch SDHA
DgiDB (Drug Gene Interaction Database)SDHA
DoCM (Curated mutations)SDHA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SDHA (select a term)
intoGenSDHA
Cancer3DSDHA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM252011    256000    600857    613642    614165   
Orphanet635    19814    3377    8775    10584   
MedgenSDHA
Genetic Testing Registry SDHA
NextProtP31040 [Medical]
TSGene6389
GENETestsSDHA
Huge Navigator SDHA [HugePedia]
snp3D : Map Gene to Disease6389
BioCentury BCIQSDHA
ClinGenSDHA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6389
Chemical/Pharm GKB GenePA35605
Clinical trialSDHA
Miscellaneous
canSAR (ICR)SDHA (select the gene name)
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSDHA
EVEXSDHA
GoPubMedSDHA
iHOPSDHA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:18:37 CEST 2017

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