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SDK1 (sidekick cell adhesion molecule 1)

Identity

Alias (NCBI)-
HGNC (Hugo) SDK1
HGNC Alias symbFLJ31425
HGNC Previous namesidekick homolog 1 (chicken)
 sidekick homolog 1, cell adhesion molecule (chicken)
LocusID (NCBI) 221935
Atlas_Id 54605
Location 7p22.2  [Link to chromosome band 7p22]
Location_base_pair Starts at 3301252 and ends at 4268999 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DPY19L1 (7p14.3) / SDK1 (7p22.2)GRB10 (7p12.1) / SDK1 (7p22.2)MICALL2 (7p22.3) / SDK1 (7p22.2)
PRKCA (17q24.2) / SDK1 (7p22.2)SDK1 (7p22.2) / AMACR (5p13.2)SDK1 (7p22.2) / CHST12 (7p22.3)
SDK1 (7p22.2) / SDK1 (7p22.2)SDK1 (7p22.2) / SETD1A (16p11.2)SDK1 (7p22.2) / XIST (Xq13.2)
VPS41 (7p14.1) / SDK1 (7p22.2)DPY19L1 7p14.3 / SDK1 7p22.2MICALL2 7p22.3 / SDK1 7p22.2
PRKCA 17q24.2 / SDK1 7p22.2SDK1 7p22.2 / CHST12 7p22.3VPS41 7p14.1 / SDK1 7p22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(7;7)(p12;p22) GRB10/SDK1


External links

 

Nomenclature
HGNC (Hugo)SDK1   19307
Cards
Entrez_Gene (NCBI)SDK1    sidekick cell adhesion molecule 1
Aliases
GeneCards (Weizmann)SDK1
Ensembl hg19 (Hinxton)ENSG00000146555 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146555 [Gene_View]  ENSG00000146555 [Sequence]  chr7:3301252-4268999 [Contig_View]  SDK1 [Vega]
ICGC DataPortalENSG00000146555
TCGA cBioPortalSDK1
AceView (NCBI)SDK1
Genatlas (Paris)SDK1
SOURCE (Princeton)SDK1
Genetics Home Reference (NIH)SDK1
Genomic and cartography
GoldenPath hg38 (UCSC)SDK1  -     chr7:3301252-4268999 +  7p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SDK1  -     7p22.2   [Description]    (hg19-Feb_2009)
GoldenPathSDK1 - 7p22.2 [CytoView hg19]  SDK1 - 7p22.2 [CytoView hg38]
ImmunoBaseENSG00000146555
Genome Data Viewer NCBISDK1 [Mapview hg19]  
OMIM607216   
Gene and transcription
Genbank (Entrez)AF131799 AK055987 AK055988 AK074077 AK074083
RefSeq transcript (Entrez)NM_001079653 NM_152744
Consensus coding sequences : CCDS (NCBI)SDK1
Gene ExpressionSDK1 [ NCBI-GEO ]   SDK1 [ EBI - ARRAY_EXPRESS ]   SDK1 [ SEEK ]   SDK1 [ MEM ]
Gene Expression Viewer (FireBrowse)SDK1 [ Firebrowse - Broad ]
GenevisibleExpression of SDK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)221935
GTEX Portal (Tissue expression)SDK1
Human Protein AtlasENSG00000146555-SDK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z5N4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z5N4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z5N4
PhosPhoSitePlusQ7Z5N4
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)FN3_dom    FN3_sf    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2   
Domain families : Pfam (Sanger)fn3 (PF00041)    I-set (PF07679)   
Domain families : Pfam (NCBI)pfam00041    pfam07679   
Domain families : Smart (EMBL)FN3 (SM00060)  IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)SDK1
SuperfamilyQ7Z5N4
AlphaFold pdb e-kbQ7Z5N4   
Human Protein Atlas [tissue]ENSG00000146555-SDK1 [tissue]
HPRD07388
Protein Interaction databases
DIP (DOE-UCLA)Q7Z5N4
IntAct (EBI)Q7Z5N4
BioGRIDSDK1
STRING (EMBL)SDK1
ZODIACSDK1
Ontologies - Pathways
QuickGOQ7Z5N4
Ontology : AmiGOplasma membrane  homophilic cell adhesion via plasma membrane adhesion molecules  homophilic cell adhesion via plasma membrane adhesion molecules  synapse assembly  synapse assembly  retina layer formation  retina layer formation  integral component of membrane  identical protein binding  synapse  synapse  cell-cell junction organization  behavioral response to cocaine  regulation of dendritic spine development  
Ontology : EGO-EBIplasma membrane  homophilic cell adhesion via plasma membrane adhesion molecules  homophilic cell adhesion via plasma membrane adhesion molecules  synapse assembly  synapse assembly  retina layer formation  retina layer formation  integral component of membrane  identical protein binding  synapse  synapse  cell-cell junction organization  behavioral response to cocaine  regulation of dendritic spine development  
NDEx NetworkSDK1
Atlas of Cancer Signalling NetworkSDK1
Wikipedia pathwaysSDK1
Orthology - Evolution
OrthoDB221935
GeneTree (enSembl)ENSG00000146555
Phylogenetic Trees/Animal Genes : TreeFamSDK1
Homologs : HomoloGeneSDK1
Homology/Alignments : Family Browser (UCSC)SDK1
Gene fusions - Rearrangements
Fusion : MitelmanDPY19L1/SDK1 [7p14.3/7p22.2]  
Fusion : MitelmanGRB10/SDK1 [7p12.1/7p22.2]  
Fusion : MitelmanMICALL2/SDK1 [7p22.3/7p22.2]  
Fusion : MitelmanPRKCA/SDK1 [17q24.2/7p22.2]  
Fusion : MitelmanSDK1/AMACR [7p22.2/5p13.2]  
Fusion : MitelmanSDK1/CHST12 [7p22.2/7p22.3]  
Fusion : MitelmanVPS41/SDK1 [7p14.1/7p22.2]  
Fusion : QuiverSDK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSDK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SDK1
dbVarSDK1
ClinVarSDK1
MonarchSDK1
1000_GenomesSDK1 
Exome Variant ServerSDK1
GNOMAD BrowserENSG00000146555
Varsome BrowserSDK1
ACMGSDK1 variants
VarityQ7Z5N4
Genomic Variants (DGV)SDK1 [DGVbeta]
DECIPHERSDK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSDK1 
Mutations
ICGC Data PortalSDK1 
TCGA Data PortalSDK1 
Broad Tumor PortalSDK1
OASIS PortalSDK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSDK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSDK1
Mutations and Diseases : HGMDSDK1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSDK1
DgiDB (Drug Gene Interaction Database)SDK1
DoCM (Curated mutations)SDK1
CIViC (Clinical Interpretations of Variants in Cancer)SDK1
Cancer3DSDK1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607216   
Orphanet
DisGeNETSDK1
MedgenSDK1
Genetic Testing Registry SDK1
NextProtQ7Z5N4 [Medical]
GENETestsSDK1
Target ValidationSDK1
Huge Navigator SDK1 [HugePedia]
ClinGenSDK1
Clinical trials, drugs, therapy
MyCancerGenomeSDK1
Protein Interactions : CTDSDK1
Pharm GKB GenePA134957188
PharosQ7Z5N4
Clinical trialSDK1
Miscellaneous
canSAR (ICR)SDK1
HarmonizomeSDK1
DataMed IndexSDK1
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSDK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:30:23 CEST 2021

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