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SDS (serine dehydratase)

Identity

Alias_symbol (synonym)SDH
Other alias
HGNC (Hugo) SDS
LocusID (NCBI) 10993
Atlas_Id 54606
Location 12q24.13  [Link to chromosome band 12q24]
Location_base_pair Starts at 113392446 and ends at 113403887 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NOC4L (12q24.33) / SDS (12q24.13)SDS (12q24.13) / GNA14 (9q21.2)NOC4L 12q24.33 / SDS 12q24.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SDS   10691
Cards
Entrez_Gene (NCBI)SDS  10993  serine dehydratase
AliasesSDH
GeneCards (Weizmann)SDS
Ensembl hg19 (Hinxton)ENSG00000135094 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135094 [Gene_View]  chr12:113392446-113403887 [Contig_View]  SDS [Vega]
ICGC DataPortalENSG00000135094
TCGA cBioPortalSDS
AceView (NCBI)SDS
Genatlas (Paris)SDS
WikiGenes10993
SOURCE (Princeton)SDS
Genetics Home Reference (NIH)SDS
Genomic and cartography
GoldenPath hg38 (UCSC)SDS  -     chr12:113392446-113403887 -  12q24.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SDS  -     12q24.13   [Description]    (hg19-Feb_2009)
EnsemblSDS - 12q24.13 [CytoView hg19]  SDS - 12q24.13 [CytoView hg38]
Mapping of homologs : NCBISDS [Mapview hg19]  SDS [Mapview hg38]
OMIM182128   
Gene and transcription
Genbank (Entrez)AK124290 AK292760 BC020750 BG534053 BG566257
RefSeq transcript (Entrez)NM_006843
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SDS
Cluster EST : UnigeneHs.439023 [ NCBI ]
CGAP (NCI)Hs.439023
Alternative Splicing GalleryENSG00000135094
Gene ExpressionSDS [ NCBI-GEO ]   SDS [ EBI - ARRAY_EXPRESS ]   SDS [ SEEK ]   SDS [ MEM ]
Gene Expression Viewer (FireBrowse)SDS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10993
GTEX Portal (Tissue expression)SDS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20132   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20132  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20132
Splice isoforms : SwissVarP20132
Catalytic activity : Enzyme4.3.1.17 [ Enzyme-Expasy ]   4.3.1.174.3.1.17 [ IntEnz-EBI ]   4.3.1.17 [ BRENDA ]   4.3.1.17 [ KEGG ]   
PhosPhoSitePlusP20132
Domaine pattern : Prosite (Expaxy)DEHYDRATASE_SER_THR (PS00165)   
Domains : Interpro (EBI)Ser/Thr_deHydtase_PyrdxlP-BS    TrpB-like_PLP-dep   
Domain families : Pfam (Sanger)PALP (PF00291)   
Domain families : Pfam (NCBI)pfam00291   
Conserved Domain (NCBI)SDS
DMDM Disease mutations10993
Blocks (Seattle)SDS
PDB (SRS)1P5J    4H27   
PDB (PDBSum)1P5J    4H27   
PDB (IMB)1P5J    4H27   
PDB (RSDB)1P5J    4H27   
Structural Biology KnowledgeBase1P5J    4H27   
SCOP (Structural Classification of Proteins)1P5J    4H27   
CATH (Classification of proteins structures)1P5J    4H27   
SuperfamilyP20132
Human Protein AtlasENSG00000135094
Peptide AtlasP20132
HPRD01633
IPIIPI00022201   IPI00791876   IPI01022337   
Protein Interaction databases
DIP (DOE-UCLA)P20132
IntAct (EBI)P20132
FunCoupENSG00000135094
BioGRIDSDS
STRING (EMBL)SDS
ZODIACSDS
Ontologies - Pathways
QuickGOP20132
Ontology : AmiGOL-serine ammonia-lyase activity  L-threonine ammonia-lyase activity  mitochondrion  cytosol  gluconeogenesis  L-serine catabolic process  pyridoxal phosphate binding  protein homodimerization activity  pyruvate biosynthetic process  
Ontology : EGO-EBIL-serine ammonia-lyase activity  L-threonine ammonia-lyase activity  mitochondrion  cytosol  gluconeogenesis  L-serine catabolic process  pyridoxal phosphate binding  protein homodimerization activity  pyruvate biosynthetic process  
Pathways : KEGGGlycine, serine and threonine metabolism    Cysteine and methionine metabolism    Valine, leucine and isoleucine biosynthesis   
NDEx NetworkSDS
Atlas of Cancer Signalling NetworkSDS
Wikipedia pathwaysSDS
Orthology - Evolution
OrthoDB10993
GeneTree (enSembl)ENSG00000135094
Phylogenetic Trees/Animal Genes : TreeFamSDS
HOVERGENP20132
HOGENOMP20132
Homologs : HomoloGeneSDS
Homology/Alignments : Family Browser (UCSC)SDS
Gene fusions - Rearrangements
Fusion : MitelmanNOC4L/SDS [12q24.33/12q24.13]  [t(12;12)(q24;q24)]  
Fusion: TCGANOC4L 12q24.33 SDS 12q24.13 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSDS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SDS
dbVarSDS
ClinVarSDS
1000_GenomesSDS 
Exome Variant ServerSDS
ExAC (Exome Aggregation Consortium)SDS (select the gene name)
Genetic variants : HAPMAP10993
Genomic Variants (DGV)SDS [DGVbeta]
DECIPHERSDS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSDS 
Mutations
ICGC Data PortalSDS 
TCGA Data PortalSDS 
Broad Tumor PortalSDS
OASIS PortalSDS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSDS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSDS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SDS
DgiDB (Drug Gene Interaction Database)SDS
DoCM (Curated mutations)SDS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SDS (select a term)
intoGenSDS
Cancer3DSDS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182128   
Orphanet
MedgenSDS
Genetic Testing Registry SDS
NextProtP20132 [Medical]
TSGene10993
GENETestsSDS
Huge Navigator SDS [HugePedia]
snp3D : Map Gene to Disease10993
BioCentury BCIQSDS
ClinGenSDS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10993
Chemical/Pharm GKB GenePA35616
Clinical trialSDS
Miscellaneous
canSAR (ICR)SDS (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSDS
EVEXSDS
GoPubMedSDS
iHOPSDS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:36:26 CEST 2017

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