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SEC11A (SEC11 homolog A, signal peptidase complex subunit)

Identity

Alias_namesSEC11L1
SEC11-like 1 (S. cerevisiae)
SEC11 homolog A (S. cerevisiae)
Alias_symbol (synonym)SPC18
sid2895
SPCS4A
Other alias1810012E07Rik
HGNC (Hugo) SEC11A
LocusID (NCBI) 23478
Atlas_Id 54865
Location 15q25.2  [Link to chromosome band 15q25]
Location_base_pair Starts at 84669537 and ends at 84716460 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARID1A (1p36.11) / SEC11A (15q25.3)SEC11A (15q25.3) / NFIA (1p31.3)VAPA (18p11.22) / SEC11A (15q25.3)
ARID1A 1p36.11 / SEC11A 15q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SEC11A   17718
Cards
Entrez_Gene (NCBI)SEC11A  23478  SEC11 homolog A, signal peptidase complex subunit
Aliases1810012E07Rik; SEC11L1; SPC18; SPCS4A; 
sid2895
GeneCards (Weizmann)SEC11A
Ensembl hg19 (Hinxton)ENSG00000140612 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140612 [Gene_View]  chr15:84669537-84716460 [Contig_View]  SEC11A [Vega]
ICGC DataPortalENSG00000140612
TCGA cBioPortalSEC11A
AceView (NCBI)SEC11A
Genatlas (Paris)SEC11A
WikiGenes23478
SOURCE (Princeton)SEC11A
Genetics Home Reference (NIH)SEC11A
Genomic and cartography
GoldenPath hg38 (UCSC)SEC11A  -     chr15:84669537-84716460 -  15q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SEC11A  -     15q25.2   [Description]    (hg19-Feb_2009)
EnsemblSEC11A - 15q25.2 [CytoView hg19]  SEC11A - 15q25.2 [CytoView hg38]
Mapping of homologs : NCBISEC11A [Mapview hg19]  SEC11A [Mapview hg38]
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001271918 NM_001271919 NM_001271920 NM_001271921 NM_001271922 NM_014300
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SEC11A
Cluster EST : UnigeneHs.9534 [ NCBI ]
CGAP (NCI)Hs.9534
Alternative Splicing GalleryENSG00000140612
Gene ExpressionSEC11A [ NCBI-GEO ]   SEC11A [ EBI - ARRAY_EXPRESS ]   SEC11A [ SEEK ]   SEC11A [ MEM ]
Gene Expression Viewer (FireBrowse)SEC11A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23478
GTEX Portal (Tissue expression)SEC11A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP67812   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP67812  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP67812
Splice isoforms : SwissVarP67812
Catalytic activity : Enzyme3.4.21.89 [ Enzyme-Expasy ]   3.4.21.893.4.21.89 [ IntEnz-EBI ]   3.4.21.89 [ BRENDA ]   3.4.21.89 [ KEGG ]   
PhosPhoSitePlusP67812
Domaine pattern : Prosite (Expaxy)SPASE_I_1 (PS00501)    SPASE_I_3 (PS00761)   
Domains : Interpro (EBI)Pept_S26A_signal_pept_1_CS    Pept_S26A_signal_pept_1_Ser-AS    Peptidase_S24/S26_b-rbn    Peptidase_S24_S26    Peptidase_S24_S26A/B/C    Peptidase_S26B   
Domain families : Pfam (Sanger)Peptidase_S24 (PF00717)   
Domain families : Pfam (NCBI)pfam00717   
Conserved Domain (NCBI)SEC11A
DMDM Disease mutations23478
Blocks (Seattle)SEC11A
SuperfamilyP67812
Human Protein AtlasENSG00000140612
Peptide AtlasP67812
HPRD07503
IPIIPI00104128   IPI00940637   IPI01023022   IPI00873608   
Protein Interaction databases
DIP (DOE-UCLA)P67812
IntAct (EBI)P67812
FunCoupENSG00000140612
BioGRIDSEC11A
STRING (EMBL)SEC11A
ZODIACSEC11A
Ontologies - Pathways
QuickGOP67812
Ontology : AmiGOsignal peptidase complex  endoplasmic reticulum membrane  signal peptide processing  peptidase activity  serine-type peptidase activity  integral component of membrane  organelle membrane  extracellular exosome  
Ontology : EGO-EBIsignal peptidase complex  endoplasmic reticulum membrane  signal peptide processing  peptidase activity  serine-type peptidase activity  integral component of membrane  organelle membrane  extracellular exosome  
Pathways : KEGGProtein export   
NDEx NetworkSEC11A
Atlas of Cancer Signalling NetworkSEC11A
Wikipedia pathwaysSEC11A
Orthology - Evolution
OrthoDB23478
GeneTree (enSembl)ENSG00000140612
Phylogenetic Trees/Animal Genes : TreeFamSEC11A
HOVERGENP67812
HOGENOMP67812
Homologs : HomoloGeneSEC11A
Homology/Alignments : Family Browser (UCSC)SEC11A
Gene fusions - Rearrangements
Fusion : MitelmanARID1A/SEC11A [1p36.11/15q25.3]  [t(1;15)(p36;q25)]  
Fusion: TCGAARID1A 1p36.11 SEC11A 15q25.3 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSEC11A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SEC11A
dbVarSEC11A
ClinVarSEC11A
1000_GenomesSEC11A 
Exome Variant ServerSEC11A
ExAC (Exome Aggregation Consortium)SEC11A (select the gene name)
Genetic variants : HAPMAP23478
Genomic Variants (DGV)SEC11A [DGVbeta]
DECIPHERSEC11A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSEC11A 
Mutations
ICGC Data PortalSEC11A 
TCGA Data PortalSEC11A 
Broad Tumor PortalSEC11A
OASIS PortalSEC11A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSEC11A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSEC11A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SEC11A
DgiDB (Drug Gene Interaction Database)SEC11A
DoCM (Curated mutations)SEC11A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SEC11A (select a term)
intoGenSEC11A
Cancer3DSEC11A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenSEC11A
Genetic Testing Registry SEC11A
NextProtP67812 [Medical]
TSGene23478
GENETestsSEC11A
Target ValidationSEC11A
Huge Navigator SEC11A [HugePedia]
snp3D : Map Gene to Disease23478
BioCentury BCIQSEC11A
ClinGenSEC11A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23478
Chemical/Pharm GKB GenePA162402586
Clinical trialSEC11A
Miscellaneous
canSAR (ICR)SEC11A (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSEC11A
EVEXSEC11A
GoPubMedSEC11A
iHOPSEC11A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:30:18 CEST 2017

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