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SEC14L3 (SEC14 like lipid binding 3)

Identity

Alias (NCBI)TAP2
HGNC (Hugo) SEC14L3
HGNC Alias symbTAP2
HGNC Alias nametocopherol-associated protein 2
HGNC Previous nameSEC14-like 3 (S. cerevisiae)
 SEC14-like lipid binding 3
LocusID (NCBI) 266629
Atlas_Id 73081
Location 22q12.2  [Link to chromosome band 22q12]
Location_base_pair Starts at 30459229 and ends at 30472047 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CPT1B (22q13.33) / SEC14L3 (22q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(22;22)(q12;q13) CPT1B/SEC14L3

External links

Nomenclature
HGNC (Hugo)SEC14L3   18655
Cards
Entrez_Gene (NCBI)SEC14L3    SEC14 like lipid binding 3
AliasesTAP2
GeneCards (Weizmann)SEC14L3
Ensembl hg19 (Hinxton)ENSG00000100012 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100012 [Gene_View]  ENSG00000100012 [Sequence]  chr22:30459229-30472047 [Contig_View]  SEC14L3 [Vega]
ICGC DataPortalENSG00000100012
TCGA cBioPortalSEC14L3
AceView (NCBI)SEC14L3
Genatlas (Paris)SEC14L3
SOURCE (Princeton)SEC14L3
Genetics Home Reference (NIH)SEC14L3
Genomic and cartography
GoldenPath hg38 (UCSC)SEC14L3  -     chr22:30459229-30472047 -  22q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SEC14L3  -     22q12.2   [Description]    (hg19-Feb_2009)
GoldenPathSEC14L3 - 22q12.2 [CytoView hg19]  SEC14L3 - 22q12.2 [CytoView hg38]
ImmunoBaseENSG00000100012
genome Data Viewer NCBISEC14L3 [Mapview hg19]  
OMIM612824   
Gene and transcription
Genbank (Entrez)AK131358 AK298079 AY158086 AY240872 BC069641
RefSeq transcript (Entrez)NM_001257378 NM_001257379 NM_001257382 NM_001376914 NM_174975
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SEC14L3
Alternative Splicing GalleryENSG00000100012
Gene ExpressionSEC14L3 [ NCBI-GEO ]   SEC14L3 [ EBI - ARRAY_EXPRESS ]   SEC14L3 [ SEEK ]   SEC14L3 [ MEM ]
Gene Expression Viewer (FireBrowse)SEC14L3 [ Firebrowse - Broad ]
GenevisibleExpression of SEC14L3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)266629
GTEX Portal (Tissue expression)SEC14L3
Human Protein AtlasENSG00000100012-SEC14L3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UDX4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UDX4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UDX4
Splice isoforms : SwissVarQ9UDX4
PhosPhoSitePlusQ9UDX4
Domaine pattern : Prosite (Expaxy)CRAL_TRIO (PS50191)    GOLD (PS50866)   
Domains : Interpro (EBI)CRAL-TRIO_dom    CRAL-TRIO_dom_sf    CRAL/TRIO_N_dom    CRAL/TRIO_N_dom_sf    GOLD_dom    GOLD_dom_sf   
Domain families : Pfam (Sanger)CRAL_TRIO (PF00650)   
Domain families : Pfam (NCBI)pfam00650   
Domain families : Smart (EMBL)CRAL_TRIO_N (SM01100)  SEC14 (SM00516)  
Conserved Domain (NCBI)SEC14L3
Blocks (Seattle)SEC14L3
PDB (RSDB)4UYB   
PDB Europe4UYB   
PDB (PDBSum)4UYB   
PDB (IMB)4UYB   
Structural Biology KnowledgeBase4UYB   
SCOP (Structural Classification of Proteins)4UYB   
CATH (Classification of proteins structures)4UYB   
SuperfamilyQ9UDX4
Human Protein Atlas [tissue]ENSG00000100012-SEC14L3 [tissue]
Peptide AtlasQ9UDX4
HPRD15311
IPIIPI00894186   IPI00894555   IPI00894077   IPI00894175   IPI00893808   IPI00893948   
Protein Interaction databases
DIP (DOE-UCLA)Q9UDX4
IntAct (EBI)Q9UDX4
BioGRIDSEC14L3
STRING (EMBL)SEC14L3
ZODIACSEC14L3
Ontologies - Pathways
QuickGOQ9UDX4
Ontology : AmiGOlipid binding  extracellular exosome  
Ontology : EGO-EBIlipid binding  extracellular exosome  
NDEx NetworkSEC14L3
Atlas of Cancer Signalling NetworkSEC14L3
Wikipedia pathwaysSEC14L3
Orthology - Evolution
OrthoDB266629
GeneTree (enSembl)ENSG00000100012
Phylogenetic Trees/Animal Genes : TreeFamSEC14L3
HOGENOMQ9UDX4
Homologs : HomoloGeneSEC14L3
Homology/Alignments : Family Browser (UCSC)SEC14L3
Gene fusions - Rearrangements
Fusion : QuiverSEC14L3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSEC14L3 [hg38]
dbVarSEC14L3
ClinVarSEC14L3
MonarchSEC14L3
1000_GenomesSEC14L3 
Exome Variant ServerSEC14L3
GNOMAD BrowserENSG00000100012
Varsome BrowserSEC14L3
Genomic Variants (DGV)SEC14L3 [DGVbeta]
DECIPHERSEC14L3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSEC14L3 
Mutations
ICGC Data PortalSEC14L3 
TCGA Data PortalSEC14L3 
Broad Tumor PortalSEC14L3
OASIS PortalSEC14L3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSEC14L3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSEC14L3
Mutations and Diseases : HGMDSEC14L3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SEC14L3
DgiDB (Drug Gene Interaction Database)SEC14L3
DoCM (Curated mutations)SEC14L3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SEC14L3 (select a term)
intoGenSEC14L3
Cancer3DSEC14L3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612824   
Orphanet
DisGeNETSEC14L3
MedgenSEC14L3
Genetic Testing Registry SEC14L3
NextProtQ9UDX4 [Medical]
GENETestsSEC14L3
Target ValidationSEC14L3
Huge Navigator SEC14L3 [HugePedia]
ClinGenSEC14L3
Clinical trials, drugs, therapy
MyCancerGenomeSEC14L3
Protein Interactions : CTD
Pharm GKB GenePA134960743
Clinical trialSEC14L3
Miscellaneous
canSAR (ICR)SEC14L3 (select the gene name)
HarmonizomeSEC14L3
DataMed IndexSEC14L3
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSEC14L3
EVEXSEC14L3
GoPubMedSEC14L3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 17:26:21 CET 2020
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