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SEC61A1 (Sec61 translocon alpha 1 subunit)

Identity

Alias_namesSec61 alpha 1 subunit (S. cerevisiae)
Other aliasHNFJ4
HSEC61
SEC61
SEC61A
HGNC (Hugo) SEC61A1
LocusID (NCBI) 29927
Atlas_Id 50367
Location 3q21.3  [Link to chromosome band 3q21]
Location_base_pair Starts at 128052369 and ends at 128071683 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DIDO1 (20q13.33) / SEC61A1 (3q21.3)GUCY1A3 (4q32.1) / SEC61A1 (3q21.3)SEC61A1 (3q21.3) / CCT5 (5p15.2)
SEC61A1 (3q21.3) / SEC61A1 (3q21.3)SNHG1 (11q12.3) / SEC61A1 (3q21.3)UBTF (17q21.31) / SEC61A1 (3q21.3)
ZC3H11A (1q32.1) / SEC61A1 (3q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SEC61A1   18276
Cards
Entrez_Gene (NCBI)SEC61A1  29927  Sec61 translocon alpha 1 subunit
AliasesHNFJ4; HSEC61; SEC61; SEC61A
GeneCards (Weizmann)SEC61A1
Ensembl hg19 (Hinxton)ENSG00000058262 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000058262 [Gene_View]  chr3:128052369-128071683 [Contig_View]  SEC61A1 [Vega]
ICGC DataPortalENSG00000058262
TCGA cBioPortalSEC61A1
AceView (NCBI)SEC61A1
Genatlas (Paris)SEC61A1
WikiGenes29927
SOURCE (Princeton)SEC61A1
Genetics Home Reference (NIH)SEC61A1
Genomic and cartography
GoldenPath hg38 (UCSC)SEC61A1  -     chr3:128052369-128071683 +  3q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SEC61A1  -     3q21.3   [Description]    (hg19-Feb_2009)
EnsemblSEC61A1 - 3q21.3 [CytoView hg19]  SEC61A1 - 3q21.3 [CytoView hg38]
Mapping of homologs : NCBISEC61A1 [Mapview hg19]  SEC61A1 [Mapview hg38]
OMIM609213   617056   
Gene and transcription
Genbank (Entrez)AF077032 AF084458 AF346602 AK001689 AK027423
RefSeq transcript (Entrez)NM_013336
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SEC61A1
Cluster EST : UnigeneHs.518236 [ NCBI ]
CGAP (NCI)Hs.518236
Alternative Splicing GalleryENSG00000058262
Gene ExpressionSEC61A1 [ NCBI-GEO ]   SEC61A1 [ EBI - ARRAY_EXPRESS ]   SEC61A1 [ SEEK ]   SEC61A1 [ MEM ]
Gene Expression Viewer (FireBrowse)SEC61A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29927
GTEX Portal (Tissue expression)SEC61A1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61619   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61619  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61619
Splice isoforms : SwissVarP61619
PhosPhoSitePlusP61619
Domaine pattern : Prosite (Expaxy)SECY_1 (PS00755)    SECY_2 (PS00756)   
Domains : Interpro (EBI)SecY/SEC61-alpha    SecY_CS    SecY_su_dom    Translocon_Sec61/SecY_plug_dom   
Domain families : Pfam (Sanger)Plug_translocon (PF10559)    SecY (PF00344)   
Domain families : Pfam (NCBI)pfam10559    pfam00344   
Conserved Domain (NCBI)SEC61A1
DMDM Disease mutations29927
Blocks (Seattle)SEC61A1
SuperfamilyP61619
Human Protein AtlasENSG00000058262
Peptide AtlasP61619
HPRD15316
IPIIPI00941172   IPI00604476   IPI00218466   IPI00946233   
Protein Interaction databases
DIP (DOE-UCLA)P61619
IntAct (EBI)P61619
FunCoupENSG00000058262
BioGRIDSEC61A1
STRING (EMBL)SEC61A1
ZODIACSEC61A1
Ontologies - Pathways
QuickGOP61619
Ontology : AmiGOprotein binding  endoplasmic reticulum membrane  rough endoplasmic reticulum  cytosol  SRP-dependent cotranslational protein targeting to membrane  posttranslational protein targeting to endoplasmic reticulum membrane  endoplasmic reticulum organization  membrane  cell growth  integral component of endoplasmic reticulum membrane  response to interferon-gamma  IRE1-mediated unfolded protein response  pronephric nephron development  ribosome binding  protein targeting to ER  
Ontology : EGO-EBIprotein binding  endoplasmic reticulum membrane  rough endoplasmic reticulum  cytosol  SRP-dependent cotranslational protein targeting to membrane  posttranslational protein targeting to endoplasmic reticulum membrane  endoplasmic reticulum organization  membrane  cell growth  integral component of endoplasmic reticulum membrane  response to interferon-gamma  IRE1-mediated unfolded protein response  pronephric nephron development  ribosome binding  protein targeting to ER  
Pathways : BIOCARTAER?associated degradation (ERAD) Pathway [Genes]   
Pathways : KEGGProtein export    Protein processing in endoplasmic reticulum    Phagosome    Vibrio cholerae infection   
NDEx NetworkSEC61A1
Atlas of Cancer Signalling NetworkSEC61A1
Wikipedia pathwaysSEC61A1
Orthology - Evolution
OrthoDB29927
GeneTree (enSembl)ENSG00000058262
Phylogenetic Trees/Animal Genes : TreeFamSEC61A1
HOVERGENP61619
HOGENOMP61619
Homologs : HomoloGeneSEC61A1
Homology/Alignments : Family Browser (UCSC)SEC61A1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSEC61A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SEC61A1
dbVarSEC61A1
ClinVarSEC61A1
1000_GenomesSEC61A1 
Exome Variant ServerSEC61A1
ExAC (Exome Aggregation Consortium)SEC61A1 (select the gene name)
Genetic variants : HAPMAP29927
Genomic Variants (DGV)SEC61A1 [DGVbeta]
DECIPHERSEC61A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSEC61A1 
Mutations
ICGC Data PortalSEC61A1 
TCGA Data PortalSEC61A1 
Broad Tumor PortalSEC61A1
OASIS PortalSEC61A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSEC61A1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSEC61A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SEC61A1
DgiDB (Drug Gene Interaction Database)SEC61A1
DoCM (Curated mutations)SEC61A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SEC61A1 (select a term)
intoGenSEC61A1
Cancer3DSEC61A1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609213    617056   
Orphanet
MedgenSEC61A1
Genetic Testing Registry SEC61A1
NextProtP61619 [Medical]
TSGene29927
GENETestsSEC61A1
Target ValidationSEC61A1
Huge Navigator SEC61A1 [HugePedia]
snp3D : Map Gene to Disease29927
BioCentury BCIQSEC61A1
ClinGenSEC61A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29927
Chemical/Pharm GKB GenePA134901772
Clinical trialSEC61A1
Miscellaneous
canSAR (ICR)SEC61A1 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSEC61A1
EVEXSEC61A1
GoPubMedSEC61A1
iHOPSEC61A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:06:49 CEST 2017

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