Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SEC61A2 (Sec61 translocon alpha 2 subunit)

Identity

Other alias-
HGNC (Hugo) SEC61A2
LocusID (NCBI) 55176
Atlas_Id 57408
Location 10p14  [Link to chromosome band 10p14]
Location_base_pair Starts at 12129641 and ends at 12165404 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SEC61A2 (10p14) / SEC61A2 (10p14)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SEC61A2   17702
Cards
Entrez_Gene (NCBI)SEC61A2  55176  Sec61 translocon alpha 2 subunit
Aliases
GeneCards (Weizmann)SEC61A2
Ensembl hg19 (Hinxton)ENSG00000065665 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000065665 [Gene_View]  ENSG00000065665 [Sequence]  chr10:12129641-12165404 [Contig_View]  SEC61A2 [Vega]
ICGC DataPortalENSG00000065665
TCGA cBioPortalSEC61A2
AceView (NCBI)SEC61A2
Genatlas (Paris)SEC61A2
WikiGenes55176
SOURCE (Princeton)SEC61A2
Genetics Home Reference (NIH)SEC61A2
Genomic and cartography
GoldenPath hg38 (UCSC)SEC61A2  -     chr10:12129641-12165404 +  10p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SEC61A2  -     10p14   [Description]    (hg19-Feb_2009)
EnsemblSEC61A2 - 10p14 [CytoView hg19]  SEC61A2 - 10p14 [CytoView hg38]
Mapping of homologs : NCBISEC61A2 [Mapview hg19]  SEC61A2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF346603 AK001440 AK022027 AK022640 AK057532
RefSeq transcript (Entrez)NM_001142627 NM_001142628 NM_018144
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SEC61A2
Cluster EST : UnigeneHs.112955 [ NCBI ]
CGAP (NCI)Hs.112955
Alternative Splicing GalleryENSG00000065665
Gene ExpressionSEC61A2 [ NCBI-GEO ]   SEC61A2 [ EBI - ARRAY_EXPRESS ]   SEC61A2 [ SEEK ]   SEC61A2 [ MEM ]
Gene Expression Viewer (FireBrowse)SEC61A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55176
GTEX Portal (Tissue expression)SEC61A2
Human Protein AtlasENSG00000065665-SEC61A2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H9S3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H9S3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H9S3
Splice isoforms : SwissVarQ9H9S3
PhosPhoSitePlusQ9H9S3
Domaine pattern : Prosite (Expaxy)SECY_1 (PS00755)    SECY_2 (PS00756)   
Domains : Interpro (EBI)SecY/SEC61-alpha    SecY_CS    SecY_dom_sf    Translocon_Sec61/SecY_plug_dom   
Domain families : Pfam (Sanger)Plug_translocon (PF10559)    SecY (PF00344)   
Domain families : Pfam (NCBI)pfam10559    pfam00344   
Conserved Domain (NCBI)SEC61A2
DMDM Disease mutations55176
Blocks (Seattle)SEC61A2
SuperfamilyQ9H9S3
Human Protein Atlas [tissue]ENSG00000065665-SEC61A2 [tissue]
Peptide AtlasQ9H9S3
IPIIPI00414427   IPI00414428   IPI00182313   IPI00647396   IPI00647854   IPI00854697   IPI00644876   IPI00982948   IPI00640481   IPI00935795   IPI01012446   IPI00640009   
Protein Interaction databases
DIP (DOE-UCLA)Q9H9S3
IntAct (EBI)Q9H9S3
FunCoupENSG00000065665
BioGRIDSEC61A2
STRING (EMBL)SEC61A2
ZODIACSEC61A2
Ontologies - Pathways
QuickGOQ9H9S3
Ontology : AmiGOmolecular_function  signal sequence binding  endoplasmic reticulum  Sec61 translocon complex  endoplasmic reticulum membrane  cytosol  SRP-dependent cotranslational protein targeting to membrane, translocation  posttranslational protein targeting to endoplasmic reticulum membrane  biological_process  protein transmembrane transporter activity  integral component of membrane  ribosome binding  
Ontology : EGO-EBImolecular_function  signal sequence binding  endoplasmic reticulum  Sec61 translocon complex  endoplasmic reticulum membrane  cytosol  SRP-dependent cotranslational protein targeting to membrane, translocation  posttranslational protein targeting to endoplasmic reticulum membrane  biological_process  protein transmembrane transporter activity  integral component of membrane  ribosome binding  
Pathways : KEGGProtein export    Protein processing in endoplasmic reticulum    Phagosome    Vibrio cholerae infection   
NDEx NetworkSEC61A2
Atlas of Cancer Signalling NetworkSEC61A2
Wikipedia pathwaysSEC61A2
Orthology - Evolution
OrthoDB55176
GeneTree (enSembl)ENSG00000065665
Phylogenetic Trees/Animal Genes : TreeFamSEC61A2
HOVERGENQ9H9S3
HOGENOMQ9H9S3
Homologs : HomoloGeneSEC61A2
Homology/Alignments : Family Browser (UCSC)SEC61A2
Gene fusions - Rearrangements
Fusion : QuiverSEC61A2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSEC61A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SEC61A2
dbVarSEC61A2
ClinVarSEC61A2
1000_GenomesSEC61A2 
Exome Variant ServerSEC61A2
ExAC (Exome Aggregation Consortium)ENSG00000065665
GNOMAD BrowserENSG00000065665
Varsome BrowserSEC61A2
Genetic variants : HAPMAP55176
Genomic Variants (DGV)SEC61A2 [DGVbeta]
DECIPHERSEC61A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSEC61A2 
Mutations
ICGC Data PortalSEC61A2 
TCGA Data PortalSEC61A2 
Broad Tumor PortalSEC61A2
OASIS PortalSEC61A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSEC61A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSEC61A2
BioMutasearch SEC61A2
DgiDB (Drug Gene Interaction Database)SEC61A2
DoCM (Curated mutations)SEC61A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SEC61A2 (select a term)
intoGenSEC61A2
Cancer3DSEC61A2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETSEC61A2
MedgenSEC61A2
Genetic Testing Registry SEC61A2
NextProtQ9H9S3 [Medical]
TSGene55176
GENETestsSEC61A2
Target ValidationSEC61A2
Huge Navigator SEC61A2 [HugePedia]
snp3D : Map Gene to Disease55176
BioCentury BCIQSEC61A2
ClinGenSEC61A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55176
Chemical/Pharm GKB GenePA134861382
Clinical trialSEC61A2
Miscellaneous
canSAR (ICR)SEC61A2 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSEC61A2
EVEXSEC61A2
GoPubMedSEC61A2
iHOPSEC61A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:37:58 CET 2018
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