Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SEC61A2 (SEC61 translocon subunit alpha 2)

Identity

Alias (NCBI)-
HGNC (Hugo) SEC61A2
HGNC Alias symbFLJ10578
HGNC Previous nameSec61 alpha 2 subunit (S. cerevisiae)
LocusID (NCBI) 55176
Atlas_Id 57408
Location 10p14  [Link to chromosome band 10p14]
Location_base_pair Starts at 12129677 and ends at 12165406 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SEC61A2 (10p14) / SEC61A2 (10p14)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)SEC61A2   17702
Cards
Entrez_Gene (NCBI)SEC61A2    SEC61 translocon subunit alpha 2
Aliases
GeneCards (Weizmann)SEC61A2
Ensembl hg19 (Hinxton)ENSG00000065665 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000065665 [Gene_View]  ENSG00000065665 [Sequence]  chr10:12129677-12165406 [Contig_View]  SEC61A2 [Vega]
ICGC DataPortalENSG00000065665
TCGA cBioPortalSEC61A2
AceView (NCBI)SEC61A2
Genatlas (Paris)SEC61A2
SOURCE (Princeton)SEC61A2
Genetics Home Reference (NIH)SEC61A2
Genomic and cartography
GoldenPath hg38 (UCSC)SEC61A2  -     chr10:12129677-12165406 +  10p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SEC61A2  -     10p14   [Description]    (hg19-Feb_2009)
GoldenPathSEC61A2 - 10p14 [CytoView hg19]  SEC61A2 - 10p14 [CytoView hg38]
ImmunoBaseENSG00000065665
Genome Data Viewer NCBISEC61A2 [Mapview hg19]  
OMIM618271   
Gene and transcription
Genbank (Entrez)AF346603 AK001440 AK022027 AK022640 AK057532
RefSeq transcript (Entrez)NM_001142627 NM_001142628 NM_018144
Consensus coding sequences : CCDS (NCBI)SEC61A2
Gene ExpressionSEC61A2 [ NCBI-GEO ]   SEC61A2 [ EBI - ARRAY_EXPRESS ]   SEC61A2 [ SEEK ]   SEC61A2 [ MEM ]
Gene Expression Viewer (FireBrowse)SEC61A2 [ Firebrowse - Broad ]
GenevisibleExpression of SEC61A2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55176
GTEX Portal (Tissue expression)SEC61A2
Human Protein AtlasENSG00000065665-SEC61A2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H9S3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H9S3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H9S3
PhosPhoSitePlusQ9H9S3
Domaine pattern : Prosite (Expaxy)SECY_1 (PS00755)    SECY_2 (PS00756)   
Domains : Interpro (EBI)SecY/SEC61-alpha    SecY_CS    SecY_dom_sf    Translocon_Sec61/SecY_plug_dom   
Domain families : Pfam (Sanger)Plug_translocon (PF10559)    SecY (PF00344)   
Domain families : Pfam (NCBI)pfam10559    pfam00344   
Conserved Domain (NCBI)SEC61A2
SuperfamilyQ9H9S3
AlphaFold pdb e-kbQ9H9S3   
Human Protein Atlas [tissue]ENSG00000065665-SEC61A2 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9H9S3
IntAct (EBI)Q9H9S3
BioGRIDSEC61A2
STRING (EMBL)SEC61A2
ZODIACSEC61A2
Ontologies - Pathways
QuickGOQ9H9S3
Ontology : AmiGOmolecular_function  signal sequence binding  Sec61 translocon complex  SRP-dependent cotranslational protein targeting to membrane, translocation  biological_process  protein transmembrane transporter activity  integral component of membrane  posttranslational protein targeting to membrane, translocation  ribosome binding  
Ontology : EGO-EBImolecular_function  signal sequence binding  Sec61 translocon complex  SRP-dependent cotranslational protein targeting to membrane, translocation  biological_process  protein transmembrane transporter activity  integral component of membrane  posttranslational protein targeting to membrane, translocation  ribosome binding  
Pathways : KEGGProtein export    Protein processing in endoplasmic reticulum    Phagosome    Vibrio cholerae infection   
NDEx NetworkSEC61A2
Atlas of Cancer Signalling NetworkSEC61A2
Wikipedia pathwaysSEC61A2
Orthology - Evolution
OrthoDB55176
GeneTree (enSembl)ENSG00000065665
Phylogenetic Trees/Animal Genes : TreeFamSEC61A2
Homologs : HomoloGeneSEC61A2
Homology/Alignments : Family Browser (UCSC)SEC61A2
Gene fusions - Rearrangements
Fusion : QuiverSEC61A2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSEC61A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SEC61A2
dbVarSEC61A2
ClinVarSEC61A2
MonarchSEC61A2
1000_GenomesSEC61A2 
Exome Variant ServerSEC61A2
GNOMAD BrowserENSG00000065665
Varsome BrowserSEC61A2
ACMGSEC61A2 variants
VarityQ9H9S3
Genomic Variants (DGV)SEC61A2 [DGVbeta]
DECIPHERSEC61A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSEC61A2 
Mutations
ICGC Data PortalSEC61A2 
TCGA Data PortalSEC61A2 
Broad Tumor PortalSEC61A2
OASIS PortalSEC61A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSEC61A2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSEC61A2
Mutations and Diseases : HGMDSEC61A2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSEC61A2
DgiDB (Drug Gene Interaction Database)SEC61A2
DoCM (Curated mutations)SEC61A2
CIViC (Clinical Interpretations of Variants in Cancer)SEC61A2
Cancer3DSEC61A2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618271   
Orphanet
DisGeNETSEC61A2
MedgenSEC61A2
Genetic Testing Registry SEC61A2
NextProtQ9H9S3 [Medical]
GENETestsSEC61A2
Target ValidationSEC61A2
Huge Navigator SEC61A2 [HugePedia]
ClinGenSEC61A2
Clinical trials, drugs, therapy
MyCancerGenomeSEC61A2
Protein Interactions : CTDSEC61A2
Pharm GKB GenePA134861382
PharosQ9H9S3
Clinical trialSEC61A2
Miscellaneous
canSAR (ICR)SEC61A2
HarmonizomeSEC61A2
DataMed IndexSEC61A2
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSEC61A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:30:26 CEST 2021
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