SEC61B (SEC61 translocon subunit beta)

2003-06-01 Affiliation

Identity

HGNC

SEC61B

LOCATION

9q22.33

LOCUSID

10952

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10952
MIM: 609214
HGNC: 16993
Ensembl: ENSG00000106803

Variants:

dbSNP: 10952
ClinVar: 10952
TCGA: ENSG00000106803
COSMIC: SEC61B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000106803	ENST00000223641	P60468
ENSG00000106803	ENST00000498603	S4R3B5

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Protein export	KEGG	ko03060
Vibrio cholerae infection	KEGG	ko05110
Protein export	KEGG	hsa03060
Vibrio cholerae infection	KEGG	hsa05110
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Sec61 complex	KEGG	hsa_M00401
Sec61 complex	KEGG	M00401
Metabolism of proteins	REACTOME	R-HSA-392499
Translation	REACTOME	R-HSA-72766
SRP-dependent cotranslational protein targeting to membrane	REACTOME	R-HSA-1799339
Unfolded Protein Response (UPR)	REACTOME	R-HSA-381119
IRE1alpha activates chaperones	REACTOME	R-HSA-381070
XBP1(S) activates chaperone genes	REACTOME	R-HSA-381038
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing-Cross presentation	REACTOME	R-HSA-1236975
ER-Phagosome pathway	REACTOME	R-HSA-1236974
Gene Expression	REACTOME	R-HSA-74160

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17215517	2007	Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression.	90
20937808	2010	The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus.	56
28375157	2017	Isolated polycystic liver disease genes define effectors of polycystin-1 function.	20
22710939	2012	Sec61β controls sensitivity to platinum-containing chemotherapeutic agents through modulation of the copper-transporting ATPase ATP7A.	8
21255561	2011	Identification of SEC61β and its autoantibody as biomarkers for colorectal cancer.	5
29168059	2018	Sec61β facilitates the maintenance of endoplasmic reticulum homeostasis by associating microtubules.	4
23037926	2012	Exocyst Sec10 is involved in basolateral protein translation and translocation in the endoplasmic reticulum.	1
24882410	2014	Sec61β regulates barrier functions of tight junction through expression of claudin-4 in Madin-Darby canine kidney cells.	0

Citation

Dessen P

SEC61B (SEC61 translocon subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42240/sec61b