SEC61G (SEC61 translocon subunit gamma)

2003-06-01  

Identity

HGNC
LOCATION
7p11.2
LOCUSID
ALIAS
SSS1
FUSION GENES

Other Information

Locus ID:

NCBI: 23480
MIM: 609215
HGNC: 18277
Ensembl: ENSG00000132432

Variants:

dbSNP: 23480
ClinVar: 23480
TCGA: ENSG00000132432
COSMIC: SEC61G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132432ENST00000352861P60059
ENSG00000132432ENST00000352861A0A024QYZ0
ENSG00000132432ENST00000395535P60059
ENSG00000132432ENST00000395535A0A024QYZ0
ENSG00000132432ENST00000415949P60059
ENSG00000132432ENST00000415949A0A024QYZ0
ENSG00000132432ENST00000450622P60059
ENSG00000132432ENST00000450622A0A024QYZ0

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Protein exportKEGGko03060
Vibrio cholerae infectionKEGGko05110
Protein exportKEGGhsa03060
Vibrio cholerae infectionKEGGhsa05110
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Sec61 complexKEGGhsa_M00401
Sec61 complexKEGGM00401
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
244975442014An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.31
290929232017Novel SEC61G-EGFR Fusion Gene in Pediatric Ependymomas Discovered by Clonal Expansion of Stem Cells in Absence of Exogenous Mitogens.3
310943632019Identification of SEC61G as a Novel Prognostic Marker for Predicting Survival and Response to Therapies in Patients with Glioblastoma.0

Citation

Dessen P

SEC61G (SEC61 translocon subunit gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42241/sec61g