SEC62 (SEC62 homolog, preprotein translocation factor)

2003-06-01  

Identity

HGNC
LOCATION
3q26.2
LOCUSID
ALIAS
Dtrp1,HTP1,TLOC1,TP-1
FUSION GENES

Other Information

Locus ID:

NCBI: 7095
MIM: 602173
HGNC: 11846
Ensembl: ENSG00000008952

Variants:

dbSNP: 7095
ClinVar: 7095
TCGA: ENSG00000008952
COSMIC: SEC62

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008952ENST00000337002Q99442
ENSG00000008952ENST00000460513F8WF48
ENSG00000008952ENST00000469515F8WCJ7
ENSG00000008952ENST00000480708Q99442
ENSG00000008952ENST00000487736F8WDG8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Protein exportKEGGko03060
Protein exportKEGGhsa03060
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
277498242016Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery.79
223750592012Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.44
226823662012Identification of cyclin B1 and Sec62 as biomarkers for recurrence in patients with HBV-related hepatocellular carcinoma after surgical resection.38
237644252013Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.28
226481692012Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation.25
243046942013Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells.20
206692232011Silencing of the SEC62 gene inhibits migratory and invasive potential of various tumor cells.19
221973832012Sec62 bridges the gap from 3q amplification to molecular cell biology in non-small cell lung cancer.18
313953422019MiR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m6A-caused stabilization of SEC62.16
165471542006Genomic and expression analysis of the 3q25-q26 amplification unit reveals TLOC1/SEC62 as a probable target gene in prostate cancer.14

Citation

Dessen P

SEC62 (SEC62 homolog, preprotein translocation factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42579/sec62