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SEC62 (SEC62 homolog, preprotein translocation factor)

Identity

Alias (NCBI)Dtrp1
HTP1
TLOC1
TP-1
HGNC (Hugo) SEC62
HGNC Alias symbDtrp1
HTP1
HGNC Previous nameTLOC1
HGNC Previous nametranslocation protein 1
 SEC62 homolog (S. cerevisiae)
LocusID (NCBI) 7095
Atlas_Id 42579
Location 3q26.2  [Link to chromosome band 3q26]
Location_base_pair Starts at 169966807 and ends at 169998373 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKS6 (9q22.33) / SEC62 (3q26.2)SEC62 (3q26.2) / SEC62 (3q26.2)THOC2 (Xq25) / SEC62 (3q26.2)
TPM4 (19p13.12) / SEC62 (3q26.2)YEATS2 (3q27.1) / SEC62 (3q26.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;3)(q33;q26) FAM117B/SEC62


External links

 

Nomenclature
HGNC (Hugo)SEC62   11846
Cards
Entrez_Gene (NCBI)SEC62    SEC62 homolog, preprotein translocation factor
AliasesDtrp1; HTP1; TLOC1; TP-1
GeneCards (Weizmann)SEC62
Ensembl hg19 (Hinxton)ENSG00000008952 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008952 [Gene_View]  ENSG00000008952 [Sequence]  chr3:169966807-169998373 [Contig_View]  SEC62 [Vega]
ICGC DataPortalENSG00000008952
TCGA cBioPortalSEC62
AceView (NCBI)SEC62
Genatlas (Paris)SEC62
SOURCE (Princeton)SEC62
Genetics Home Reference (NIH)SEC62
Genomic and cartography
GoldenPath hg38 (UCSC)SEC62  -     chr3:169966807-169998373 +  3q26.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SEC62  -     3q26.2   [Description]    (hg19-Feb_2009)
GoldenPathSEC62 - 3q26.2 [CytoView hg19]  SEC62 - 3q26.2 [CytoView hg38]
ImmunoBaseENSG00000008952
Genome Data Viewer NCBISEC62 [Mapview hg19]  
OMIM602173   
Gene and transcription
Genbank (Entrez)AK025548 AK057365 AK294504 BC003677 BC007040
RefSeq transcript (Entrez)NM_003262
Consensus coding sequences : CCDS (NCBI)SEC62
Gene ExpressionSEC62 [ NCBI-GEO ]   SEC62 [ EBI - ARRAY_EXPRESS ]   SEC62 [ SEEK ]   SEC62 [ MEM ]
Gene Expression Viewer (FireBrowse)SEC62 [ Firebrowse - Broad ]
GenevisibleExpression of SEC62 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7095
GTEX Portal (Tissue expression)SEC62
Human Protein AtlasENSG00000008952-SEC62 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99442   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99442  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99442
PhosPhoSitePlusQ99442
Domains : Interpro (EBI)Sec62   
Domain families : Pfam (Sanger)Sec62 (PF03839)   
Domain families : Pfam (NCBI)pfam03839   
Conserved Domain (NCBI)SEC62
PDB (RSDB)7BRT   
PDB Europe7BRT   
PDB (PDBSum)7BRT   
PDB (IMB)7BRT   
Structural Biology KnowledgeBase7BRT   
SCOP (Structural Classification of Proteins)7BRT   
CATH (Classification of proteins structures)7BRT   
SuperfamilyQ99442
AlphaFold pdb e-kbQ99442   
Human Protein Atlas [tissue]ENSG00000008952-SEC62 [tissue]
HPRD03706
Protein Interaction databases
DIP (DOE-UCLA)Q99442
IntAct (EBI)Q99442
BioGRIDSEC62
STRING (EMBL)SEC62
ZODIACSEC62
Ontologies - Pathways
QuickGOQ99442
Ontology : AmiGOendoplasmic reticulum  rough endoplasmic reticulum  cotranslational protein targeting to membrane  posttranslational protein targeting to endoplasmic reticulum membrane  membrane  membrane  integral component of membrane  integral component of endoplasmic reticulum membrane  posttranslational protein targeting to membrane, translocation  posttranslational protein targeting to membrane, translocation  signaling receptor activity  
Ontology : EGO-EBIendoplasmic reticulum  rough endoplasmic reticulum  cotranslational protein targeting to membrane  posttranslational protein targeting to endoplasmic reticulum membrane  membrane  membrane  integral component of membrane  integral component of endoplasmic reticulum membrane  posttranslational protein targeting to membrane, translocation  posttranslational protein targeting to membrane, translocation  signaling receptor activity  
Pathways : KEGGProtein export    Protein processing in endoplasmic reticulum   
NDEx NetworkSEC62
Atlas of Cancer Signalling NetworkSEC62
Wikipedia pathwaysSEC62
Orthology - Evolution
OrthoDB7095
GeneTree (enSembl)ENSG00000008952
Phylogenetic Trees/Animal Genes : TreeFamSEC62
Homologs : HomoloGeneSEC62
Homology/Alignments : Family Browser (UCSC)SEC62
Gene fusions - Rearrangements
Fusion : MitelmanYEATS2/SEC62 [3q27.1/3q26.2]  
Fusion : QuiverSEC62
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSEC62 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SEC62
dbVarSEC62
ClinVarSEC62
MonarchSEC62
1000_GenomesSEC62 
Exome Variant ServerSEC62
GNOMAD BrowserENSG00000008952
Varsome BrowserSEC62
ACMGSEC62 variants
VarityQ99442
Genomic Variants (DGV)SEC62 [DGVbeta]
DECIPHERSEC62 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSEC62 
Mutations
ICGC Data PortalSEC62 
TCGA Data PortalSEC62 
Broad Tumor PortalSEC62
OASIS PortalSEC62 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSEC62  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSEC62
Mutations and Diseases : HGMDSEC62
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSEC62
DgiDB (Drug Gene Interaction Database)SEC62
DoCM (Curated mutations)SEC62
CIViC (Clinical Interpretations of Variants in Cancer)SEC62
Cancer3DSEC62
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602173   
Orphanet
DisGeNETSEC62
MedgenSEC62
Genetic Testing Registry SEC62
NextProtQ99442 [Medical]
GENETestsSEC62
Target ValidationSEC62
Huge Navigator SEC62 [HugePedia]
ClinGenSEC62
Clinical trials, drugs, therapy
MyCancerGenomeSEC62
Protein Interactions : CTDSEC62
Pharm GKB GenePA162402849
PharosQ99442
Clinical trialSEC62
Miscellaneous
canSAR (ICR)SEC62
HarmonizomeSEC62
DataMed IndexSEC62
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSEC62
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:30:26 CEST 2021

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