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SEC62 (SEC62 homolog, preprotein translocation factor)

Identity

Alias_namesTLOC1
translocation protein 1
SEC62 homolog (S. cerevisiae)
Alias_symbol (synonym)Dtrp1
HTP1
Other aliasTP-1
HGNC (Hugo) SEC62
LocusID (NCBI) 7095
Atlas_Id 42579
Location 3q26.2  [Link to chromosome band 3q26]
Location_base_pair Starts at 169966792 and ends at 169998373 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKS6 (9q22.33) / SEC62 (3q26.2)SEC62 (3q26.2) / SEC62 (3q26.2)THOC2 (Xq25) / SEC62 (3q26.2)
TPM4 (19p13.12) / SEC62 (3q26.2)YEATS2 (3q27.1) / SEC62 (3q26.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SEC62   11846
Cards
Entrez_Gene (NCBI)SEC62  7095  SEC62 homolog, preprotein translocation factor
AliasesDtrp1; HTP1; TLOC1; TP-1
GeneCards (Weizmann)SEC62
Ensembl hg19 (Hinxton)ENSG00000008952 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008952 [Gene_View]  chr3:169966792-169998373 [Contig_View]  SEC62 [Vega]
ICGC DataPortalENSG00000008952
TCGA cBioPortalSEC62
AceView (NCBI)SEC62
Genatlas (Paris)SEC62
WikiGenes7095
SOURCE (Princeton)SEC62
Genetics Home Reference (NIH)SEC62
Genomic and cartography
GoldenPath hg38 (UCSC)SEC62  -     chr3:169966792-169998373 +  3q26.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SEC62  -     3q26.2   [Description]    (hg19-Feb_2009)
EnsemblSEC62 - 3q26.2 [CytoView hg19]  SEC62 - 3q26.2 [CytoView hg38]
Mapping of homologs : NCBISEC62 [Mapview hg19]  SEC62 [Mapview hg38]
OMIM602173   
Gene and transcription
Genbank (Entrez)AK025548 AK057365 AK294504 BC003677 BC007040
RefSeq transcript (Entrez)NM_003262
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SEC62
Cluster EST : UnigeneHs.744859 [ NCBI ]
CGAP (NCI)Hs.744859
Alternative Splicing GalleryENSG00000008952
Gene ExpressionSEC62 [ NCBI-GEO ]   SEC62 [ EBI - ARRAY_EXPRESS ]   SEC62 [ SEEK ]   SEC62 [ MEM ]
Gene Expression Viewer (FireBrowse)SEC62 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7095
GTEX Portal (Tissue expression)SEC62
Human Protein AtlasENSG00000008952-SEC62 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99442   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99442  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99442
Splice isoforms : SwissVarQ99442
PhosPhoSitePlusQ99442
Domains : Interpro (EBI)Sec62    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Sec62 (PF03839)   
Domain families : Pfam (NCBI)pfam03839   
Conserved Domain (NCBI)SEC62
DMDM Disease mutations7095
Blocks (Seattle)SEC62
SuperfamilyQ99442
Human Protein Atlas [tissue]ENSG00000008952-SEC62 [tissue]
Peptide AtlasQ99442
HPRD03706
IPIIPI00019004   IPI00910668   IPI00945991   IPI00945578   IPI00946327   IPI01015861   
Protein Interaction databases
DIP (DOE-UCLA)Q99442
IntAct (EBI)Q99442
FunCoupENSG00000008952
BioGRIDSEC62
STRING (EMBL)SEC62
ZODIACSEC62
Ontologies - Pathways
QuickGOQ99442
Ontology : AmiGOreceptor activity  endoplasmic reticulum  endoplasmic reticulum membrane  rough endoplasmic reticulum  cytosol  cotranslational protein targeting to membrane  posttranslational protein targeting to endoplasmic reticulum membrane  protein transporter activity  membrane  integral component of membrane  IRE1-mediated unfolded protein response  
Ontology : EGO-EBIreceptor activity  endoplasmic reticulum  endoplasmic reticulum membrane  rough endoplasmic reticulum  cytosol  cotranslational protein targeting to membrane  posttranslational protein targeting to endoplasmic reticulum membrane  protein transporter activity  membrane  integral component of membrane  IRE1-mediated unfolded protein response  
Pathways : KEGGProtein export    Protein processing in endoplasmic reticulum   
NDEx NetworkSEC62
Atlas of Cancer Signalling NetworkSEC62
Wikipedia pathwaysSEC62
Orthology - Evolution
OrthoDB7095
GeneTree (enSembl)ENSG00000008952
Phylogenetic Trees/Animal Genes : TreeFamSEC62
HOVERGENQ99442
HOGENOMQ99442
Homologs : HomoloGeneSEC62
Homology/Alignments : Family Browser (UCSC)SEC62
Gene fusions - Rearrangements
Fusion : MitelmanYEATS2/SEC62 [3q27.1/3q26.2]  [t(3;3)(q26;q27)]  
Tumor Fusion PortalSEC62
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSEC62 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SEC62
dbVarSEC62
ClinVarSEC62
1000_GenomesSEC62 
Exome Variant ServerSEC62
ExAC (Exome Aggregation Consortium)ENSG00000008952
GNOMAD BrowserENSG00000008952
Genetic variants : HAPMAP7095
Genomic Variants (DGV)SEC62 [DGVbeta]
DECIPHERSEC62 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSEC62 
Mutations
ICGC Data PortalSEC62 
TCGA Data PortalSEC62 
Broad Tumor PortalSEC62
OASIS PortalSEC62 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSEC62  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSEC62
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SEC62
DgiDB (Drug Gene Interaction Database)SEC62
DoCM (Curated mutations)SEC62 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SEC62 (select a term)
intoGenSEC62
Cancer3DSEC62(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602173   
Orphanet
DisGeNETSEC62
MedgenSEC62
Genetic Testing Registry SEC62
NextProtQ99442 [Medical]
TSGene7095
GENETestsSEC62
Target ValidationSEC62
Huge Navigator SEC62 [HugePedia]
snp3D : Map Gene to Disease7095
BioCentury BCIQSEC62
ClinGenSEC62
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7095
Chemical/Pharm GKB GenePA162402849
Clinical trialSEC62
Miscellaneous
canSAR (ICR)SEC62 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSEC62
EVEXSEC62
GoPubMedSEC62
iHOPSEC62
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in Pu`Med<.TL>
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:33:53 CET 2017

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