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SEC63 (SEC63 homolog, protein translocation regulator)

Identity

Other namesDNAJC23
ERdj2
PRO2507
SEC63L
HGNC (Hugo) SEC63
LocusID (NCBI) 11231
Atlas_Id 42242
Location 6q21
Location_base_pair Starts at 108188960 and ends at 108279482 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AP2M1 (3q27.1) / SEC63 (6q21)APP (21q21.3) / SEC63 (6q21)DGCR2 (22q11.21) / SEC63 (6q21)
GLUL (1q25.3) / SEC63 (6q21)GPX3 (5q33.1) / SEC63 (6q21)GPX4 (19p13.3) / SEC63 (6q21)
JUNB (19p13.2) / SEC63 (6q21)LOC202781 () / SEC63 (6q21)NDRG2 (14q11.2) / SEC63 (6q21)
P4HB (17q25.3) / SEC63 (6q21)PHC1 (12p13.31) / SEC63 (6q21)PRPF4B (6p25.2) / SEC63 (6q21)
SEC63 (6q21) / CELSR3 (3p21.31)SEC63 (6q21) / FIG4 (6q21)SEC63 (6q21) / LRRC39 (1p21.2)
SEC63 (6q21) / MIR548O2 (8p12)SPARCL1 (4q22.1) / SEC63 (6q21)AP2M1 3q27.1 / SEC63 6q21
APP 21q21.3 / SEC63 6q21DGCR2 22q11.21 / SEC63 6q21GLUL 1q25.3 / SEC63 6q21
GPX3 5q33.1 / SEC63 6q21GPX4 19p13.3 / SEC63 6q21JUNB 19p13.2 / SEC63 6q21
NDRG2 14q11.2 / SEC63 6q21P4HB 17q25.3 / SEC63 6q21SEC63 6q21 / FIG4 6q21
SPARCL1 4q22.1 / SEC63 6q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SEC63   21082
Cards
Entrez_Gene (NCBI)SEC63  11231  SEC63 homolog, protein translocation regulator
AliasesDNAJC23; ERdj2; PRO2507; SEC63L
GeneCards (Weizmann)SEC63
Ensembl hg19 (Hinxton)ENSG00000025796 [Gene_View]  chr6:108188960-108279482 [Contig_View]  SEC63 [Vega]
Ensembl hg38 (Hinxton)ENSG00000025796 [Gene_View]  chr6:108188960-108279482 [Contig_View]  SEC63 [Vega]
ICGC DataPortalENSG00000025796
TCGA cBioPortalSEC63
AceView (NCBI)SEC63
Genatlas (Paris)SEC63
WikiGenes11231
SOURCE (Princeton)SEC63
Genomic and cartography
GoldenPath hg19 (UCSC)SEC63  -     chr6:108188960-108279482 -  6q21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SEC63  -     6q21   [Description]    (hg38-Dec_2013)
EnsemblSEC63 - 6q21 [CytoView hg19]  SEC63 - 6q21 [CytoView hg38]
Mapping of homologs : NCBISEC63 [Mapview hg19]  SEC63 [Mapview hg38]
OMIM174050   608648   
Gene and transcription
Genbank (Entrez)AF100141 AF119883 AI559292 AJ011779 AJ420532
RefSeq transcript (Entrez)NM_007214 NM_018529
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_008270 NT_025741 NW_004929328
Consensus coding sequences : CCDS (NCBI)SEC63
Cluster EST : UnigeneHs.26904 [ NCBI ]
CGAP (NCI)Hs.26904
Alternative Splicing GalleryENSG00000025796
Gene ExpressionSEC63 [ NCBI-GEO ]   SEC63 [ EBI - ARRAY_EXPRESS ]   SEC63 [ SEEK ]   SEC63 [ MEM ]
Gene Expression Viewer (FireBrowse)SEC63 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11231
GTEX Portal (Tissue expression)SEC63
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGP8 (Uniprot)
NextProtQ9UGP8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UGP8
Splice isoforms : SwissVarQ9UGP8 (Swissvar)
PhosPhoSitePlusQ9UGP8
Domaine pattern : Prosite (Expaxy)DNAJ_2 (PS50076)   
Domains : Interpro (EBI)C2_dom    DnaJ_domain    Ig_E-set    Sec63-dom   
Domain families : Pfam (Sanger)DnaJ (PF00226)    Sec63 (PF02889)   
Domain families : Pfam (NCBI)pfam00226    pfam02889   
Domain families : Smart (EMBL)DnaJ (SM00271)  SEC63 (SM00611)  Sec63 (SM00973)  
DMDM Disease mutations11231
Blocks (Seattle)SEC63
SuperfamilyQ9UGP8
Human Protein AtlasENSG00000025796
Peptide AtlasQ9UGP8
HPRD09783
IPIIPI00218922   IPI00902496   IPI00903261   IPI00383314   IPI00852625   IPI00893574   
Protein Interaction databases
DIP (DOE-UCLA)Q9UGP8
IntAct (EBI)Q9UGP8
FunCoupENSG00000025796
BioGRIDSEC63
STRING (EMBL)SEC63
ZODIACSEC63
Ontologies - Pathways
QuickGOQ9UGP8
Ontology : AmiGOliver development  receptor activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  protein targeting to membrane  SRP-dependent cotranslational protein targeting to membrane  posttranslational protein targeting to membrane  nitrogen compound metabolic process  multicellular organism aging  membrane  integral component of membrane  IRE1-mediated unfolded protein response  poly(A) RNA binding  renal system development  
Ontology : EGO-EBIliver development  receptor activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  cytosol  protein targeting to membrane  SRP-dependent cotranslational protein targeting to membrane  posttranslational protein targeting to membrane  nitrogen compound metabolic process  multicellular organism aging  membrane  integral component of membrane  IRE1-mediated unfolded protein response  poly(A) RNA binding  renal system development  
Pathways : KEGGProtein export    Protein processing in endoplasmic reticulum   
NDEx Network
Atlas of Cancer Signalling NetworkSEC63
Wikipedia pathwaysSEC63
Orthology - Evolution
OrthoDB11231
GeneTree (enSembl)ENSG00000025796
Phylogenetic Trees/Animal Genes : TreeFamSEC63
Homologs : HomoloGeneSEC63
Homology/Alignments : Family Browser (UCSC)SEC63
Gene fusions - Rearrangements
Fusion: TCGAAP2M1 3q27.1 SEC63 6q21 THCA
Fusion: TCGAAPP 21q21.3 SEC63 6q21 THCA
Fusion: TCGADGCR2 22q11.21 SEC63 6q21 BRCA
Fusion: TCGAGLUL 1q25.3 SEC63 6q21 LGG
Fusion: TCGAGPX3 5q33.1 SEC63 6q21 THCA
Fusion: TCGAGPX4 19p13.3 SEC63 6q21 THCA
Fusion: TCGAJUNB 19p13.2 SEC63 6q21 THCA
Fusion: TCGANDRG2 14q11.2 SEC63 6q21 LGG
Fusion: TCGAP4HB 17q25.3 SEC63 6q21 SKCM
Fusion: TCGASEC63 6q21 FIG4 6q21 LAML
Fusion: TCGASPARCL1 4q22.1 SEC63 6q21 LGG
Polymorphisms : SNP, variants
NCBI Variation ViewerSEC63 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SEC63
dbVarSEC63
ClinVarSEC63
1000_GenomesSEC63 
Exome Variant ServerSEC63
ExAC (Exome Aggregation Consortium)SEC63 (select the gene name)
Genetic variants : HAPMAP11231
Genomic Variants (DGV)SEC63 [DGVbeta]
Mutations
ICGC Data PortalSEC63 
TCGA Data PortalSEC63 
Broad Tumor PortalSEC63
OASIS PortalSEC63 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSEC63 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SEC63
DgiDB (Drug Gene Interaction Database)SEC63
DoCM (Curated mutations)SEC63 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SEC63 (select a term)
intoGenSEC63
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:108188960-108279482  ENSG00000025796
CONAN: Copy Number AnalysisSEC63 
Mutations and Diseases : HGMDSEC63
OMIM174050    608648   
MedgenSEC63
Genetic Testing Registry SEC63
NextProtQ9UGP8 [Medical]
TSGene11231
GENETestsSEC63
Huge Navigator SEC63 [HugePedia]
snp3D : Map Gene to Disease11231
BioCentury BCIQSEC63
ClinGenSEC63
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11231
Chemical/Pharm GKB GenePA134936990
Clinical trialSEC63
Miscellaneous
canSAR (ICR)SEC63 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSEC63
EVEXSEC63
GoPubMedSEC63
iHOPSEC63
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:20:22 CEST 2016

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