SECTM1 (secreted and transmembrane 1)

2012-02-01  

Identity

HGNC
SECTM1
LOCATION
17q25.3
LOCUSID
6398
ALIAS
K12,SECTM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6398
MIM: 602602
HGNC: 10707
Ensembl: ENSG00000141574

Variants:

dbSNP: 6398
ClinVar: 6398
TCGA: ENSG00000141574
COSMIC: SECTM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141574ENST00000269389Q8WVN6
ENSG00000141574ENST00000580437J3QQU6
ENSG00000141574ENST00000581691J3KTR4
ENSG00000141574ENST00000581864J3QR99
ENSG00000141574ENST00000581954J3QRU5
ENSG00000141574ENST00000582290J3KS40
ENSG00000141574ENST00000582563J3QKK2
ENSG00000141574ENST00000583093J3KSN0

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
204069642010Risk of meningioma and common variation in genes related to innate immunity.12
241574612014SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway.7
204387852010Polymorphisms in innate immunity genes and risk of childhood leukemia.5
217499092011The T/NK cell co-stimulatory molecule SECTM1 is an IFN "early response gene" that is negatively regulated by LPS in human monocytic cells.5
242112522014Autocrine GM-CSF transcription in the leukemic progenitor cell line KG1a is mediated by the transcription factor ETS1 and is negatively regulated through SECTM1 mediated ligation of CD7.2

Citation

Dessen P

SECTM1 (secreted and transmembrane 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52581/sectm1