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SELE (selectin E, endothelial adhesion molecule 1)

Written2008-05Gregorio Seidita, Giacomo De Leo, Riccardo Alessandro
Dipartimento Biopatologie e Metodologie Biomediche, via divisi, 83 - 90133 Palermo, Italy

(Note : for Links provided by Atlas : click)


Alias (NCBI)CD62E
HGNC Alias symbESEL
HGNC Previous nameELAM1
HGNC Previous nameendothelial adhesion molecule 1
LocusID (NCBI) 6401
Atlas_Id 42247
Location 1q24.2  [Link to chromosome band 1q24]
Location_base_pair Starts at 169722640 and ends at 169734079 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping SELE.png]
Local_order centromere....SELP - SELL - SELE - C1orf156 - C1orf112.....telomere
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)


Note Member of the Selectin family. ELAM and CD62E, two of the alternative gene names, have continued to be used in the literature for this gene.
  Exons are represented by solid blue rectangles and introns by black lines.The drawing is in scale.
Description This gene can be found on Chromosome 1 at location 167,958,406-167,969,803. The gene is composed of 14 exons, spanning approximately 12 kb of genomic DNA in the telomere-to-centromere orientation on chromosome region 1q22-1q25. The promoter region is not included.
Transcription NM_000450 3834 bp mRNA. The sequence is supported by several sequences (cDNA clones) and produces, by alternative splicing, 5 different protein isoforms (6 transcripts). The transcripts differ by truncation of the N-terminus, truncation of the C-terminus, presence or absence of an exon.
Pseudogene None


Description Selectin E precursor is composed of 610 amino acids (66655 Da). Subcellular location: Membrane; Single-pass type I membrane protein. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues (Sushi domains). E-Selectin belongs to the selectin family of proteins. Amino acids: 610; Molecular Weight: 66655 Dalton. The phosphorylation on Tyr-603 (cytoplasmic domain) is required for the E-selectin-dependent ERK1 / ERK2 activation.
Expression The endothelial leukocyte adhesion molecule-1 is ubiquitously expressed in normal tissues. SELE is expressed at high level in cytokine-stimulated endothelial cells.
Localisation Single-pass type I membrane protein.
Function E-Selectin is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.
Homology Using pairwise alignment function of ClustalW2, the corresponding sequences from Mus musculus and Rattus norvegicus match with a score of 72 and 73 respectively.


Note Since adhesion molecules such as members of the selectin family participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis, Wenzel et al. (1994) sought DNA polymorphisms in the ELAM1 gene, which appears to be expressed only in activated endothelium. They identified an A-to-C transversion at cDNA nucleotide 561, resulting in an amino acid exchange from serine to arginine at codon 128 (S128R) in the epidermal growth factor-like domain. They found a significantly higher frequency of the mutation in 97 patients aged 50 years or less with angiographically proven severe atherosclerosis (arginine allele frequency, 0.155) compared with an unselected population (arginine allele frequency, 0.088), as well as in 40 patients aged 40 years or less (arginine allele frequency, 0.21). Mutations of the gene may be a risk factor in atherosclerosis. A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).Genomewide linkage and candidate gene-based association studies demonstrated that variation in 3 genes on 1q23 is important in the determination of differences in blood pressure levels: ATP1B1 (182330), RGS5 (603276), and SELE (Takei et al, 2002; 131210). E-selectin S128R polymorphism can functionally affect tumor-endothelial interactions as well as motility and signaling properties of neoplastic cells that may modulate the metastatic phenotype (Alessandro et al, 2007).

Implicated in

Entity Recruiting blood leukocytes to the site of inflammation
Note E-selectin plays an important role in recruiting leukocytes to the site of inflammation. E-selectin is expressed on endothelial cells in response to inflammatory cytokines IL-1 and TNF-alpha (Bevilacqua et al., 1989). Leukocytes in the blood expressing the correct ligand will bind with low affinity to E-selectin, causing the leukocytes to "roll" along the internal surface of the blood vessel as temporary interactions are made and broken. For these reasons the protein encoded by this gene is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining.
Entity Coronary artery disease
Note Risk of acquiring coronary artery disease in patients with type 2 diabetes mellitus increases significantly in the presence of the 128R mutant allele of the E-selectin gene (Abu Amero et al., 2007). Other authors correlated the G98T mutation in the E-selectin gene with a higher risk of premature coronary artery disease (Zheng et al., 2001). Data from other laboratories confirmed the hypothesis that in systemic inflammation altered E-selectin shedding may play a role in arterial damage and implicated this adhesion molecule in atherosclerotic complications in a high-risk condition (Malatino et al., 2007)
Entity Colon carcinoma
Note Transendothelial migration of colon carcinoma cells
Oncogenesis E-selectin mediates the adhesion of tumor cells to endothelial cells, and this interaction is associated with metastatic dissemination. Alessandro et al.(2007) studied the S128R polymorphism in the E-selectin gene in patients with metastatic colon cancer and its functional significance. Genotyping for S128R polymorphism was performed on 172 cancer patients and on an age-matched control population demonstrated that the R128 allele was more prevalent in the metastatic patients group than in the non metastatic group or normal controls. In vitro, S128R E-selectin transfected Huvec cells, supported increased adhesion as well as increased cellular signalling of T84 cancer cells compared to WT E-selectin and mock transfected Huvec cells. These findings suggest that the E-selectin S128R polymorphism can functionally affect tumor-endothelial interactions as well as motility and signaling properties of neoplastic cells. These interactions may ultimately modulate the metastatic phenotype.
Entity Angiogenesis
Note E-selectin plays an important role in endostatin-mediated antiangiogenesis. E-selectin is required for the antiangiogenic activity of endostatin in vivo and ex vivo, and is sufficient, via a mechanism requiring the E-selectin cytoplasmic domain, to confer endostatin sensitivity in endothelial cells in vitro (Yu et al., 2004).


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Clin Exp Metastasis. 2004;21(3):257-64.
PMID 15387376
FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB.
Lee DK, Kang JE, Park HJ, Kim MH, Yim TH, Kim JM, Heo MK, Kim KY, Kwon HJ, Hur MW.
J Biol Chem. 2005 Jul 29;280(30):27783-91.
PMID 15917220
Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells.
Lee YW, Eum SY, Nath A, Toborek M.
Cardiovasc Res. 2004 Jul 1;63(1):139-48.
PMID 15194470
Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin.
Li F, Wilkins PP, Crawley S, Weinstein J, Cummings RD, McEver RP.
J Biol Chem. 1996 Feb 9;271(6):3255-64.
PMID 8621728
Association between the Ser128Arg variant of the E-selectin and risk of coronary artery disease in the central China.
Li Y, Wei YS, Wang M, Zhang PA, Jiang XJ, Huang CX.
Int J Cardiol. 2005 Aug 3;103(1):33-6.
PMID 16061120
Relationship between circulating E-selectin, DD genotype of angiotensin-converting-enzyme, and cardiovascular damage in central obese subjects.
Licata G, Di Chiara T, Licata A, Triolo G, Argano C, Pinto A, Parrinello G, Corrao S, Duro G, Scaglione R.
Metabolism. 2003 Aug;52(8):999-1004.
PMID 12898464
Down regulation of endothelial adhesion molecules in node positive breast cancer: possible failure of host defence mechanism.
Madhavan M, Srinivas P, Abraham E, Ahmed I, Vijayalekshmi NR, Balaram P.
Pathol Oncol Res. 2002;8(2):125-8.
PMID 12172576
Circulating E-selectin as a risk marker in patients with end-stage renal disease.
Malatino LS, Stancanelli B, Cataliotti A, Bellanuova I, Fatuzzo P, Rapisarda F, Leonardis D, Tripepi G, Mallamaci F, Zoccali C.
J Intern Med. 2007 Oct;262(4):479-87.
PMID 17875185
Soluble cell adhesion molecules in hypertensive concentric left ventricular hypertrophy.
Malmqvist K, Wallén HN, Held C, Kahan T.
J Hypertens. 2002 Aug;20(8):1563-9.
PMID 12172318
An investigation of the interactions of E-selectin with fuco-oligosaccharides of the blood group family.
Martín MJ, Feizi T, Leteux C, Pavlovic D, Piskarev VE, Chai W.
Glycobiology. 2002 Dec;12(12):829-35.
PMID 12499405
The Leu554Phe polymorphism in the E-selectin gene is associated with blood pressure in overweight people.
Marteau JB, Sass C, Pfister M, Lambert D, Noyer-Weidner M, Visvikis S.
J Hypertens. 2004 Feb;22(2):305-11.
PMID 15076188
Serum levels of adhesion molecules correlate with insulin resistance.
Matsumoto K, Sera Y, Miyake S, Ueki Y.
Atherosclerosis. 2002 Mar;161(1):243-4.
PMID 11882338
Different mechanisms of adhesion molecule expression in human dermal microvascular endothelial cells by xanthoma tissue-mediated and copper-mediated oxidized low density lipoproteins.
Matsumoto M, Ikeda M, Seike M, Kodama H.
J Dermatol Sci. 2003 Jun;32(1):43-54.
PMID 12788528
E-selectin genotypes and risk of type 2 diabetes in women.
Meigs JB, Hu FB, Perhanidis JS, Hunter D, Rifai N, Manson JE.
Obes Res. 2005 Mar;13(3):513-8.
PMID 15833936
Expression of endothelial protein C receptor and thrombomodulin in human coronary atherosclerotic plaques.
Merlini PA, Rossi ML, Faioni EM, Franchi F, Bramucci E, Lucreziotti S, Biguzzi E, Mannucci PM, Ardissino D.
Ital Heart J. 2004 Jan;5(1):42-7.
PMID 15080580
Modelling the carbohydrate recognition domain of human E-selectin.
Mills A.
FEBS Lett. 1993 Mar 15;319(1-2):5-11.
PMID 7681016
HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium.
Mrowiec T, Melchar C, Górski A.
Arch Immunol Ther Exp (Warsz). 1997;45(2-3):255-9.
PMID 9597096
Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid.
Nübel T, Dippold W, Kaina B, Fritz G.
Carcinogenesis. 2004 Aug;25(8):1335-44.
PMID 14988223
Endothelial adhesion molecules in glomerular lesions: association with their severity and diversity in lupus models.
Nakatani K, Fujii H, Hasegawa H, Terada M, Arita N, Ito MR, Ono M, Takahashi S, Saiga K, Yoshimoto S, Iwano M, Shiiki H, Saito Y, Nose M.
Kidney Int. 2004 Apr;65(4):1290-300.
PMID 15086468
sE-Selectin expression and A561C polymorphism in relation to rheumatoid arthritis clinical activity.
Navarro-Hernández RE, Oregón-Romero E, Rangel-Villalobos H, Vázquez-Del Mercado M, Ruiz-Quezada SL, Maldonado-González M, Torres-Vitela R, Muñoz-Valle JF.
J Rheumatol. 2006 Oct;33(10):1968-72.
PMID 17014013
Effects of modified low density lipoprotein and hypoxia on the expression of endothelial leukocyte adhesion molecule-1.
Okada M, Sugita O, Miida T, Matsuto T, Inano K.
Presse Med. 1995 Mar 11;24(10):483-8.
PMID 7538217
ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex.
Phillips ML, Nudelman E, Gaeta FC, Perez M, Singhal AK, Hakomori S, Paulson JC.
Science. 1990 Nov 23;250(4984):1130-2.
PMID 1701274
Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase.
Piconi L, Quagliaro L, Da Ros R, Assaloni R, Giugliano D, Esposito K, Szabó C, Ceriello A.
J Thromb Haemost. 2004 Aug;2(8):1453-9.
PMID 15304054
Body weight and glucose metabolism have a different effect on circulating levels of ICAM-1, E-selectin, and endothelin-1 in humans.
Pontiroli AE, Pizzocri P, Koprivec D, Vedani P, Marchi M, Arcelloni C, Paroni R, Esposito K, Giugliano D.
Eur J Endocrinol. 2004 Feb;150(2):195-200.
PMID 14763917
Quantification of the influence of mycophenolic acid on the release of endothelial adhesion molecules.
Raab M, Daxecker H, Pavlovic V, Griesmacher A, Mueller MM.
Clin Chim Acta. 2002 Jun;320(1-2):89-94.
PMID 11983205
The Ser128Arg polymorphism for E-selectin gene and brucellosis.
Rafiei A, Hajilooi M, Vahedi M, Shakib RJ.
Infect Genet Evol. 2007 Jul;7(4):494-8.
PMID 17392035
Enhanced recruitment of Th2 and CLA-negative lymphocytes by the S128R polymorphism of E-selectin.
Rao RM, Haskard DO, Landis RC.
J Immunol. 2002 Nov 15;169(10):5860-5.
PMID 12421968
Soluble selectin levels in patients with lung cancer.
Roselli M, Mineo TC, Martini F, Mariotti S, Ambrogi V, Spila A, D'Alessandro R, Basili S, Guadagni F, Ferroni P.
Int J Biol Markers. 2002 Jan-Mar;17(1):56-62.
PMID 11936588
Cell-cell contact mechanisms.
Ryan US, Worthington RE.
Curr Opin Immunol. 1992 Feb;4(1):33-7. (REVIEW)
PMID 1375831
Circulating endothelial adhesion molecules (sE-selectin, sVCAM-1 and sICAM-1) during rHuG-CSF-stimulated stem cell mobilization.
Südhoff T, Söhngen D.
J Hematother Stem Cell Res. 2002 Feb;11(1):147-51.
PMID 11847011
Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort.
Sass C, Pallaud C, Zannad F, Visvikis S.
Hum Genet. 2000 Jul;107(1):58-61.
PMID 10982036
Contribution of selectin ligands to eosinophil recruitment into the skin of patients with atopic dermatitis.
Satoh T, Kaneko M, Wu MH, Yokozeki H, Nishioka K.
Eur J Immunol. 2002 May;32(5):1274-81.
PMID 11981814
High serum soluble E-selectin levels are associated with postoperative haematogenic recurrence in esophageal squamous cell carcinoma patients.
Shimada Y, Maeda M, Watanabe G, Imamura M.
Oncol Rep. 2003 Jul-Aug;10(4):991-5.
PMID 12792758
Soluble VCAM-1 and E-selectin in breast cancer: relationship with staging and with the detection of circulating cancer cells.
Silva HC, Garcao F, Coutinho EC, De Oliveira CF, Regateiro FJ.
Neoplasma. 2006;53(6):538-43.
PMID 17167725
Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women.
Song Y, Manson JE, Tinker L, Rifai N, Cook NR, Hu FB, Hotamisligil GS, Ridker PM, Rodriguez BL, Margolis KL, Oberman A, Liu S.
Diabetes. 2007 Jul;56(7):1898-904.
PMID 17389327
Divergent fates of P- and E-selectins after their expression on the plasma membrane.
Subramaniam M, Koedam JA, Wagner DD.
Mol Biol Cell. 1993 Aug;4(8):791-801.
PMID 7694691
AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent.
Sundell CL, Somers PK, Meng CQ, Hoong LK, Suen KL, Hill RR, Landers LK, Chapman A, Butteiger D, Jones M, Edwards D, Daugherty A, Wasserman MA, Alexander RW, Medford RM, Saxena U.
J Pharmacol Exp Ther. 2003 Jun;305(3):1116-23.
PMID 12626663
Human soluble E-selectin immunoadhesin inhibits leukemic monocyte adhesion to endothelial cells.
Sung BH, Kim SH, Yeo MG, Kim JK, Song WK.
Cell Biochem Funct. 2007 Sep-Oct;25(5):585-9.
PMID 16892455
A cholesterol-independent membrane microdomain serves as a functional counter-receptor for E-selectin at the Colo201 cell surface and initiates signalling on E-selectin binding.
Suzuki C, Kojima N.
J Biochem. 2007 Jul;142(1):55-64.
PMID 17684030
Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy.
Takei T, Iida A, Nitta K, Tanaka T, Ohnishi Y, Yamada R, Maeda S, Tsunoda T, Takeoka S, Ito K, Honda K, Uchida K, Tsuchiya K, Suzuki Y, Fujioka T, Ujiie T, Nagane Y, Miyano S, Narita I, Gejyo F, Nihei H, Nakamura Y.
Am J Hum Genet. 2002 Mar;70(3):781-6.
PMID 11828340
Increased E-selectin, IL-8 and IL-10 gene expression in human skin after minimal trauma.
Takeuchi F, Sterilein RD, Hall RP 3rd.
Exp Dermatol. 2003 Dec;12(6):777-83.
PMID 14714557
E-selectin gene expression is induced synergistically with the coexistence of activated classic protein kinase C and signals elicited by interleukin-1beta but not tumor necrosis factor-alpha.
Tamaru M, Narumi S.
J Biol Chem. 1999 Feb 5;274(6):3753-63.
PMID 9920928
Soluble E-selectin, leptin, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients.
Taniguchi A, Fukushima M, Nakai Y, Kuroe A, Yamano G, Yanagawa T, Ohgushi M, Ohya M, Yoshii S, Taki Y, Seino Y.
Metabolism. 2005 Mar;54(3):376-80.
PMID 15736116
In vivo evidence for close association of CLA expression and E-selectin binding by T cells in the inflamed skin.
Teraki Y, Miyake A, Takebayashi R, Shiohara T.
J Dermatol Sci. 2004 Oct;36(1):63-5.
PMID 15488708
The E-selectin gene polymorphism and carotid atherosclerosis in end-stage renal disease.
Testa A, Benedetto FA, Spoto B, Pisano A, Tripepi G, Mallamaci F, Malatino LS, Zoccali C.
Nephrol Dial Transplant. 2006 Jul;21(7):1921-6.
PMID 16554320
Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin.
Totani L, Piccoli A, Manarini S, Federico L, Pecce R, Martelli N, Cerletti C, Piccardoni P, Lowell CA, Smyth SS, Berton G, Evangelista V.
Biochem J. 2006 May 15;396(1):89-98.
PMID 16433632
17beta-Estradiol inhibits cytokine induction of the human E-selectin promoter.
Tyree CM, Zou A, Allegretto EA.
J Steroid Biochem Mol Biol. 2002 Mar;80(3):291-7.
PMID 11948013
Serum levels of soluble E-selectin in colorectal cancer.
Uner A, Akcali Z, Unsal D.
Neoplasma. 2004;51(4):269-74.
PMID 15254658
A novel leptospiral protein increases ICAM-1 and E-selectin expression in human umbilical vein endothelial cells.
Vieira ML, D'Atri LP, Schattner M, Habarta AM, Barbosa AS, de Morais ZM, Vasconcellos SA, Abreu PA, Gomez RM, Nascimento AL.
FEMS Microbiol Lett. 2007 Nov;276(2):172-80.
PMID 17956423
Thiocyanate-dependent induction of endothelial cell adhesion molecule expression by phagocyte peroxidases: a novel HOSCN-specific oxidant mechanism to amplify inflammation.
Wang JG, Mahmud SA, Nguyen J, Slungaard A.
J Immunol. 2006 Dec 15;177(12):8714-22.
PMID 17142773
Impact of selectin gene polymorphisms on rapid progression to end-stage renal disease in patients with IgA nephropathy.
Watanabe Y, Inoue T, Okada H, Kotaki S, Kanno Y, Kikuta T, Suzuki H.
Intern Med. 2006;45(16):947-
PMID 16974056
Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1.
Watson ML, Kingsmore SF, Johnston GI, Siegelman MH, Le Beau MM, Lemons RS, Bora NS, Howard TA, Weissman IL, McEver RP, et al.
J Exp Med. 1990 Jul 1;172(1):263-72.
PMID 1694218
DNA polymorphisms in adhesion molecule genes--a new risk factor for early atherosclerosis.
Wenzel K, Ernst M, Rohde K, Baumann G, Speer A.
Hum Genet. 1996 Jan;97(1):15-20.
PMID 8557254
E-selectin polymorphism and atherosclerosis: an association study.
Wenzel K, Felix S, Kleber FX, Brachold R, Menke T, Schattke S, Schulte KL, Gläser C, Rohde K, Baumann G, et al.
Hum Mol Genet. 1994 Nov;3(11):1935-7.
PMID 7533025
Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians.
Weyer C, Yudkin JS, Stehouwer CD, Schalkwijk CG, Pratley RE, Tataranni PA.
Atherosclerosis. 2002 Mar;161(1):233-42.
PMID 11882337
Affinity, kinetics, and thermodynamics of E-selectin binding to E-selectin ligand-1.
Wild MK, Huang MC, Schulze-Horsel U, van der Merwe PA, Vestweber D.
J Biol Chem. 2001 Aug 24;276(34):31602-12.
PMID 11404363
Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1.
Winkler IG, Snapp KR, Simmons PJ, Lévesque JP.
Blood. 2004 Mar 1;103(5):1685-92.
PMID 14592840
Blood serum levels of soluble forms of adhesion molecules ICAM-1 (sICAM-1) and selectin E (s-selectin E) in patients with various phases of non-Hodgkin's lymphomas.
Wolowiec D, Frydecka I, Kapelko-Slowik K, Potoczek S, Urbaniak-Kujda D, Kuliczkowski K.
Med Sci Monit. 2002 May;8(5):BR175-8.
PMID 12011765
A PstI polymorphism detects the mutation of serine128 to arginine in CD 62E gene - a risk factor for coronary artery disease.
Ye SQ, Usher D, Virgil D, Zhang LQ, Yochim SE, Gupta R.
J Biomed Sci. 1999 Jan;6(1):18-21.
PMID 9933738
Serum E-selectin and erythrocyte membrane Na+K+ ATPase levels in patients with rheumatoid arthritis.
Yildirim K, Senel K, Karatay S, Sisecioglu M, Kiziltunc A, Ugur M, Akcay F.
Cell Biochem Funct. 2005 Jul-Aug;23(4):285-9.
PMID 15515123
E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions.
Yoshida M, Takano Y, Sasaoka T, Izumi T, Kimura A.
Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):783-8.
PMID 12649084
Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton.
Yoshida M, Westlin WF, Wang N, Ingber DE, Rosenzweig A, Resnick N, Gimbrone MA Jr.
J Cell Biol. 1996 Apr;133(2):445-55.
PMID 8609175
E-selectin is required for the antiangiogenic activity of endostatin.
Yu Y, Moulton KS, Khan MK, Vineberg S, Boye E, Davis VM, O'Donnell PE, Bischoff J, Milstone DS.
Proc Natl Acad Sci U S A. 2004 May 25;101(21):8005-10.
PMID 15148373
L-selectin from human, but not from mouse neutrophils binds directly to E-selectin.
Zöllner O, Lenter MC, Blanks JE, Borges E, Steegmaier M, Zerwes HG, Vestweber D.
J Cell Biol. 1997 Feb 10;136(3):707-16.
PMID 9024699
E-selectin and its ligand-sLeX in the metastasis of hepatocellular carcinoma.
Zhang BH, Chen H, Yao XP, Cong WM, Wu MC.
Hepatobiliary Pancreat Dis Int. 2002 Feb;1(1):80-2.
PMID 14607629
L-selectin and E-selectin expressed on monocytes mediating Ehrlichia chaffeensis attachment onto host cells.
Zhang JZ, McBride JW, Yu XJ.
FEMS Microbiol Lett. 2003 Oct 24;227(2):303-9.
PMID 14592723
An HphI polymorphism in the E-selectin gene is associated with premature coronary artery disease.
Zheng F, Chevalier JA, Zhang LQ, Virgil D, Ye SQ, Kwiterovich PO.
Clin Genet. 2001 Jan;59(1):58-64.
PMID 11168027


This paper should be referenced as such :
Seidita, G ; De, Leo G ; Alessandro, R
SELE (selectin E, endothelial adhesion molecule 1)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(4):285-292.
Free journal version : [ pdf ]   [ DOI ]

External links


HGNC (Hugo)SELE   10718
Entrez_Gene (NCBI)SELE    selectin E
AliasesCD62E; ELAM; ELAM1; ESEL; 
GeneCards (Weizmann)SELE
Ensembl hg19 (Hinxton)ENSG00000007908 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000007908 [Gene_View]  ENSG00000007908 [Sequence]  chr1:169722640-169734079 [Contig_View]  SELE [Vega]
ICGC DataPortalENSG00000007908
Genatlas (Paris)SELE
SOURCE (Princeton)SELE
Genetics Home Reference (NIH)SELE
Genomic and cartography
GoldenPath hg38 (UCSC)SELE  -     chr1:169722640-169734079 -  1q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SELE  -     1q24.2   [Description]    (hg19-Feb_2009)
GoldenPathSELE - 1q24.2 [CytoView hg19]  SELE - 1q24.2 [CytoView hg38]
Genome Data Viewer NCBISELE [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK314214 AY367062 BC131551 BC142677 BC142711
RefSeq transcript (Entrez)NM_000450
Consensus coding sequences : CCDS (NCBI)SELE
Gene ExpressionSELE [ NCBI-GEO ]   SELE [ EBI - ARRAY_EXPRESS ]   SELE [ SEEK ]   SELE [ MEM ]
Gene Expression Viewer (FireBrowse)SELE [ Firebrowse - Broad ]
GenevisibleExpression of SELE in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6401
GTEX Portal (Tissue expression)SELE
Human Protein AtlasENSG00000007908-SELE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16581   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16581  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16581
Domaine pattern : Prosite (Expaxy)C_TYPE_LECTIN_1 (PS00615)    C_TYPE_LECTIN_2 (PS50041)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    SUSHI (PS50923)   
Domains : Interpro (EBI)C-type_lectin-like    C-type_lectin-like/link_sf    C-type_lectin_CS    CTDL_fold    EGF-like_dom    Selectin_CTLD    Selectin_superfamily    Sushi/SCR/CCP_sf    Sushi_SCR_CCP_dom   
Domain families : Pfam (Sanger)EGF (PF00008)    Lectin_C (PF00059)    Sushi (PF00084)   
Domain families : Pfam (NCBI)pfam00008    pfam00059    pfam00084   
Domain families : Smart (EMBL)CCP (SM00032)  CLECT (SM00034)  EGF (SM00181)  
Conserved Domain (NCBI)SELE
PDB (RSDB)1ESL    1G1T    1KJA    4C16    4CSY    6EYI    6EYJ    6EYK   
PDB Europe1ESL    1G1T    1KJA    4C16    4CSY    6EYI    6EYJ    6EYK   
PDB (PDBSum)1ESL    1G1T    1KJA    4C16    4CSY    6EYI    6EYJ    6EYK   
PDB (IMB)1ESL    1G1T    1KJA    4C16    4CSY    6EYI    6EYJ    6EYK   
Structural Biology KnowledgeBase1ESL    1G1T    1KJA    4C16    4CSY    6EYI    6EYJ    6EYK   
SCOP (Structural Classification of Proteins)1ESL    1G1T    1KJA    4C16    4CSY    6EYI    6EYJ    6EYK   
CATH (Classification of proteins structures)1ESL    1G1T    1KJA    4C16    4CSY    6EYI    6EYJ    6EYK   
AlphaFold pdb e-kbP16581   
Human Protein Atlas [tissue]ENSG00000007908-SELE [tissue]
Protein Interaction databases
IntAct (EBI)P16581
Ontologies - Pathways
Ontology : AmiGOpositive regulation of receptor internalization  leukocyte migration involved in inflammatory response  transmembrane signaling receptor activity  protein binding  extracellular space  extracellular space  plasma membrane  integral component of plasma membrane  caveola  clathrin-coated pit  inflammatory response  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  leukocyte cell-cell adhesion  activation of phospholipase C activity  external side of plasma membrane  calcium-mediated signaling  actin filament-based process  cortical cytoskeleton  response to lipopolysaccharide  sialic acid binding  sialic acid binding  response to cytokine  response to tumor necrosis factor  phospholipase binding  membrane raft  metal ion binding  perinuclear region of cytoplasm  regulation of inflammatory response  leukocyte migration  leukocyte tethering or rolling  leukocyte tethering or rolling  oligosaccharide binding  oligosaccharide binding  response to interleukin-1  positive regulation of leukocyte tethering or rolling  
Ontology : EGO-EBIpositive regulation of receptor internalization  leukocyte migration involved in inflammatory response  transmembrane signaling receptor activity  protein binding  extracellular space  extracellular space  plasma membrane  integral component of plasma membrane  caveola  clathrin-coated pit  inflammatory response  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  leukocyte cell-cell adhesion  activation of phospholipase C activity  external side of plasma membrane  calcium-mediated signaling  actin filament-based process  cortical cytoskeleton  response to lipopolysaccharide  sialic acid binding  sialic acid binding  response to cytokine  response to tumor necrosis factor  phospholipase binding  membrane raft  metal ion binding  perinuclear region of cytoplasm  regulation of inflammatory response  leukocyte migration  leukocyte tethering or rolling  leukocyte tethering or rolling  oligosaccharide binding  oligosaccharide binding  response to interleukin-1  positive regulation of leukocyte tethering or rolling  
Pathways : BIOCARTAMonocyte and its Surface Molecules [Genes]    Neutrophil and Its Surface Molecules [Genes]    Adhesion Molecules on Lymphocyte [Genes]   
Pathways : KEGGCell adhesion molecules (CAMs)    TNF signaling pathway    African trypanosomiasis    Malaria   
REACTOMEP16581 [protein]
REACTOME PathwaysR-HSA-202733 [pathway]   
NDEx NetworkSELE
Atlas of Cancer Signalling NetworkSELE
Wikipedia pathwaysSELE
Orthology - Evolution
GeneTree (enSembl)ENSG00000007908
Phylogenetic Trees/Animal Genes : TreeFamSELE
Homologs : HomoloGeneSELE
Homology/Alignments : Family Browser (UCSC)SELE
Gene fusions - Rearrangements
Fusion : QuiverSELE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSELE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SELE
Exome Variant ServerSELE
GNOMAD BrowserENSG00000007908
Varsome BrowserSELE
ACMGSELE variants
Genomic Variants (DGV)SELE [DGVbeta]
DECIPHERSELE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSELE 
ICGC Data PortalSELE 
TCGA Data PortalSELE 
Broad Tumor PortalSELE
OASIS PortalSELE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSELE  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSELE
Mutations and Diseases : HGMDSELE
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
DgiDB (Drug Gene Interaction Database)SELE
DoCM (Curated mutations)SELE
CIViC (Clinical Interpretations of Variants in Cancer)SELE
NCG (London)SELE
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry SELE
NextProtP16581 [Medical]
Target ValidationSELE
Huge Navigator SELE [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTDSELE
Pharm GKB GenePA35640
Clinical trialSELE
DataMed IndexSELE
PubMed448 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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