SELENBP1 (selenium binding protein 1)

2003-06-01  

Identity

HGNC
SELENBP1
LOCATION
1q21.3
LOCUSID
8991
ALIAS
EHMTO,HEL-S-134P,LPSB,MTO,SBP56,SP56,hSBP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8991
MIM: 604188
HGNC: 10719
Ensembl: ENSG00000143416

Variants:

dbSNP: 8991
ClinVar: 8991
TCGA: ENSG00000143416
COSMIC: SELENBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143416ENST00000368868Q13228
ENSG00000143416ENST00000368868V9HWG1
ENSG00000143416ENST00000423070F8WCR4
ENSG00000143416ENST00000424475H0Y532
ENSG00000143416ENST00000426705Q13228
ENSG00000143416ENST00000427867C9JVL0
ENSG00000143416ENST00000427977F2Z2W8
ENSG00000143416ENST00000443708F2Z2W8
ENSG00000143416ENST00000447402Q13228
ENSG00000143416ENST00000455397F2Z2W8
ENSG00000143416ENST00000455839F8WBA9
ENSG00000143416ENST00000458566A6PVX1

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163809932006Selenium binding protein 1 in ovarian cancer.46
166459842006Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival.42
205302372010Functional and physical interaction between the selenium-binding protein 1 (SBP1) and the glutathione peroxidase 1 selenoprotein.36
184354902008Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer.34
199243032009Transcriptional regulation and biological functions of selenium-binding protein 1 in colorectal cancer in vitro and in nude mouse xenografts.31
203323232010Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity.30
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
191185332009Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner.27
213387162011Structural and functional studies of the human selenium binding protein-1 and its involvement in hepatocellular carcinoma.22
220725822012Inverse association between glutathione peroxidase activity and both selenium-binding protein 1 levels and Gleason score in human prostate tissue.22

Citation

Dessen P

SELENBP1 (selenium binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42248/selenbp1