SELENOH (selenoprotein H)

2018-02-01  

Identity

HGNC
LOCATION
11q12.1
LOCUSID
ALIAS
C11orf31,C17orf10,SELH

Other Information

Locus ID:

NCBI: 280636
MIM: 607914
HGNC: 18251
Ensembl: ENSG00000211450

Variants:

dbSNP: 280636
ClinVar: 280636
TCGA: ENSG00000211450
COSMIC: SELENOH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000211450ENST00000388857Q8IZQ5
ENSG00000211450ENST00000528798H0YE28
ENSG00000211450ENST00000534355Q8IZQ5
ENSG00000211450ENST00000622257A0A087WYP2

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232201722013Overexpression of human selenoprotein H in neuronal cells enhances mitochondrial biogenesis and function through activation of protein kinase A, protein kinase B, and cyclic adenosine monophosphate response element-binding protein pathway.7
275888992016Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.7
210480312011Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.5
173374532007Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern.0
173899262007Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation.0
175264922007Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification.0
197661172009Overexpression of human selenoprotein H in neuronal cells ameliorates ultraviolet irradiation-induced damage by modulating cell signaling pathways.0
206560652011Upregulation of human selenoprotein H in murine hippocampal neuronal cells promotes mitochondrial biogenesis and functional performance.0
253366342014Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation.0
293300962018Selenoprotein H controls cell cycle progression and proliferation of human colorectal cancer cells.0

Citation

Dessen P

SELENOH (selenoprotein H)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57281/selenoh