Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SEMA4A (semaphorin 4A)

Identity

Alias_namesSEMAB
sema domain
Alias_symbol (synonym)SemB
FLJ12287
CORD10
Other aliasRP35
SEMB
HGNC (Hugo) SEMA4A
LocusID (NCBI) 64218
Atlas_Id 55553
Location 1q22  [Link to chromosome band 1q22]
Location_base_pair Starts at 156153531 and ends at 156177751 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SEMA4A (1q22) / RPL7L1 (6p21.1)SNX10 (7p15.2) / SEMA4A (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SEMA4A   10729
Cards
Entrez_Gene (NCBI)SEMA4A  64218  semaphorin 4A
AliasesCORD10; RP35; SEMAB; SEMB
GeneCards (Weizmann)SEMA4A
Ensembl hg19 (Hinxton)ENSG00000196189 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196189 [Gene_View]  chr1:156153531-156177751 [Contig_View]  SEMA4A [Vega]
ICGC DataPortalENSG00000196189
TCGA cBioPortalSEMA4A
AceView (NCBI)SEMA4A
Genatlas (Paris)SEMA4A
WikiGenes64218
SOURCE (Princeton)SEMA4A
Genetics Home Reference (NIH)SEMA4A
Genomic and cartography
GoldenPath hg38 (UCSC)SEMA4A  -     chr1:156153531-156177751 +  1q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SEMA4A  -     1q22   [Description]    (hg19-Feb_2009)
EnsemblSEMA4A - 1q22 [CytoView hg19]  SEMA4A - 1q22 [CytoView hg38]
Mapping of homologs : NCBISEMA4A [Mapview hg19]  SEMA4A [Mapview hg38]
OMIM607292   610282   610283   
Gene and transcription
Genbank (Entrez)AA761091 AB029394 AK022349 AK022416 AK091127
RefSeq transcript (Entrez)NM_001193300 NM_001193301 NM_001193302 NM_022367
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SEMA4A
Cluster EST : UnigeneHs.408846 [ NCBI ]
CGAP (NCI)Hs.408846
Alternative Splicing GalleryENSG00000196189
Gene ExpressionSEMA4A [ NCBI-GEO ]   SEMA4A [ EBI - ARRAY_EXPRESS ]   SEMA4A [ SEEK ]   SEMA4A [ MEM ]
Gene Expression Viewer (FireBrowse)SEMA4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64218
GTEX Portal (Tissue expression)SEMA4A
Human Protein AtlasENSG00000196189-SEMA4A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H3S1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H3S1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H3S1
Splice isoforms : SwissVarQ9H3S1
PhosPhoSitePlusQ9H3S1
Domaine pattern : Prosite (Expaxy)SEMA (PS51004)   
Domains : Interpro (EBI)Plexin_repeat    PSI    Semap_dom    Semaphorin    WD40/YVTN_repeat-like_dom   
Domain families : Pfam (Sanger)PSI (PF01437)    Sema (PF01403)   
Domain families : Pfam (NCBI)pfam01437    pfam01403   
Domain families : Smart (EMBL)PSI (SM00423)  Sema (SM00630)  
Conserved Domain (NCBI)SEMA4A
DMDM Disease mutations64218
Blocks (Seattle)SEMA4A
SuperfamilyQ9H3S1
Human Protein Atlas [tissue]ENSG00000196189-SEMA4A [tissue]
Peptide AtlasQ9H3S1
HPRD09528
IPIIPI00149097   IPI00646820   IPI00645285   IPI00514991   IPI00640907   IPI00640504   
Protein Interaction databases
DIP (DOE-UCLA)Q9H3S1
IntAct (EBI)Q9H3S1
FunCoupENSG00000196189
BioGRIDSEMA4A
STRING (EMBL)SEMA4A
ZODIACSEMA4A
Ontologies - Pathways
QuickGOQ9H3S1
Ontology : AmiGOangiogenesis  protein binding  nucleus  cytosol  plasma membrane  axonogenesis  regulation of cell shape  regulation of endothelial cell migration  integral component of membrane  negative regulation of angiogenesis  intracellular membrane-bounded organelle  T-helper 1 cell differentiation  semaphorin-plexin signaling pathway  
Ontology : EGO-EBIangiogenesis  protein binding  nucleus  cytosol  plasma membrane  axonogenesis  regulation of cell shape  regulation of endothelial cell migration  integral component of membrane  negative regulation of angiogenesis  intracellular membrane-bounded organelle  T-helper 1 cell differentiation  semaphorin-plexin signaling pathway  
Pathways : KEGGAxon guidance   
NDEx NetworkSEMA4A
Atlas of Cancer Signalling NetworkSEMA4A
Wikipedia pathwaysSEMA4A
Orthology - Evolution
OrthoDB64218
GeneTree (enSembl)ENSG00000196189
Phylogenetic Trees/Animal Genes : TreeFamSEMA4A
HOVERGENQ9H3S1
HOGENOMQ9H3S1
Homologs : HomoloGeneSEMA4A
Homology/Alignments : Family Browser (UCSC)SEMA4A
Gene fusions - Rearrangements
Fusion: Tumor Portal SEMA4A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSEMA4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SEMA4A
dbVarSEMA4A
ClinVarSEMA4A
1000_GenomesSEMA4A 
Exome Variant ServerSEMA4A
ExAC (Exome Aggregation Consortium)ENSG00000196189
GNOMAD BrowserENSG00000196189
Genetic variants : HAPMAP64218
Genomic Variants (DGV)SEMA4A [DGVbeta]
DECIPHERSEMA4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSEMA4A 
Mutations
ICGC Data PortalSEMA4A 
TCGA Data PortalSEMA4A 
Broad Tumor PortalSEMA4A
OASIS PortalSEMA4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSEMA4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSEMA4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch SEMA4A
DgiDB (Drug Gene Interaction Database)SEMA4A
DoCM (Curated mutations)SEMA4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SEMA4A (select a term)
intoGenSEMA4A
Cancer3DSEMA4A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607292    610282    610283   
Orphanet659    1843    23409   
MedgenSEMA4A
Genetic Testing Registry SEMA4A
NextProtQ9H3S1 [Medical]
TSGene64218
GENETestsSEMA4A
Target ValidationSEMA4A
Huge Navigator SEMA4A [HugePedia]
snp3D : Map Gene to Disease64218
BioCentury BCIQSEMA4A
ClinGenSEMA4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64218
Chemical/Pharm GKB GenePA35651
Clinical trialSEMA4A
Miscellaneous
canSAR (ICR)SEMA4A (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSEMA4A
EVEXSEMA4A
GoPubMedSEMA4A
iHOPSEMA4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:10:12 CET 2017

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